Development of Novel Nano Niosomes As Drug Delivery System of Spermacoce hispida Extract and In Vitro Antituberculosis Activity

Anghore, Durgadas; Kulkarni, Giriraj T.

doi:10.2174/2405461502666170314151949

Cited by 17 publications

(3 citation statements)

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“…Monoterpene hydrocarbons were found to overflow all four oils, with limonene being the most incessant. The antifungal properties of the oils were considered, and the most dynamic oil (Citrus lemon) was set into hexosomal scattering and tried once again against similar organisms [123].…”

Section: Hexosomesmentioning

confidence: 99%

Treatment opportunities with Fernandoa adenophylla and recent novel approaches for natural medicinal phytochemicals as a drug delivery system

Mall

Yadav

Waziri

et al. 2022

Exploration of Medicine

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Fernandoa adenophylla (FA, Heterophragma adenophyllum) is a plant, cultivated throughout Africa and Southeast Asia. It contains potent phytochemicals such as novel naphthoquinones, their derivatives (peshwaraquinone, dilapachone, adenophyllone, indadone, and lapachol), and triterpenoids [ursolic acid (UA), β-sitosterol (BS), α-amyrin, and oleanolic acid (OA)] that have been assessed and reported to show potential pharmacological activities. The crude extract obtained from the plant has been investigated for certain pharmacological activities such as antibacterial, antifungal, anti-tubercular (TB), antihypertensive, and leishmanicidal activity. A novel drug delivery systems (NDDS) is the latest technique that combines innovative development, formulations, new technology, and methodologies for the safe delivery of pharmaceutical substances in the body. The present study reports the possible treatment opportunities of FA and recent possible novel drug delivery approaches for the natural medicinal phytochemicals.

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Section: Hexosomesmentioning

confidence: 99%

Treatment opportunities with Fernandoa adenophylla and recent novel approaches for natural medicinal phytochemicals as a drug delivery system

Mall

Yadav

Waziri

et al. 2022

Exploration of Medicine

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“…101 More examples of herbal loaded niosome are shown in Table 1. [102][103][104][105][106] Ethosome It is a novel liposome that defined as a soft, non-invasive lipid-based elastic vesicles ( Figure 5D) developed for topical, transdermal and systemic applications with the high efficient ability of both hydrophilic and lipophilic drugs and active ingredient delivery to deeper skin layers and blood circulation. 8,10 Ethosome is composed of water, certain phospholipids (phosphatidylcholine, phosphatidylserine, phosphatidylethanolamine, and phosphatidylglycerol), and a relatively high concentration of alcohol (30-45%) (ethanol and isopropyl alcohol).…”

Section: Transferosomementioning

confidence: 99%

Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications

Rahman

Othman

Hammadi

et al. 2020

IJN

157

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Many types of research have distinctly addressed the efficacy of natural plant metabolites used for human consumption both in cell culture and preclinical animal model systems. However, these in vitro and in vivo effects have not been able to be translated for clinical use because of several factors such as inefficient systemic delivery and bioavailability of promising agents that significantly contribute to this disconnection. Over the past decades, extraordinary advances have been made successfully on the development of novel drug delivery systems for encapsulation of plant active metabolites including organic, inorganic and hybrid nanoparticles. The advanced formulas are confirmed to have extraordinary benefits over conventional and previously used systems in the manner of solubility, bioavailability, toxicity, pharmacological activity, stability, distribution, sustained delivery, and both physical and chemical degradation. The current review highlights the development of novel nanocarrier for plant active compounds, their method of preparation, type of active ingredients, and their biomedical applications.

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“…[ 5 ] Overall, Spermacoce hispida stands as an example of a medicinal plant deeply rooted in traditional medicine systems and under investigation for its potential therapeutic applications (Anghore and Kulkarni, 2017). [ 6 ] As research advances, a clearer picture of its medicinal properties and potential benefits continues to emerge, paving the way for the development of natural products with diverse health-promoting properties.…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Anti-Inflammatory and Anti-Oxidant Activities of Spermacoce Hispida Ethanolic Extract

Nithin Krishna,

Krishnamoorthy,

Veeraraghavan

et al. 2024

Journal of Pharmacy and Bioallied Sciences

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Background: Spermacoce hispida, a medicinal plant from the Rubiaceae family, has garnered attention for its traditional use and reported therapeutic properties. This study aimed to investigate the phytochemical composition and assess the anti-inflammatory and anti-oxidant activities of the ethanolic extract derived from Spermacoce hispida. Materials and Methods: Phytochemical screening of the ethanolic extract involved qualitative analysis to identify major phytoconstituents such as tannins, phenols, and acids. The anti-inflammatory activity was evaluated through in vitro assays, and anti-oxidant potential was assessed using established methods to measure scavenging activity against free radicals and reactive oxygen species. Results: Phytochemical screening revealed the presence of various bioactive constituents in the Spermacoce hispida ethanolic extract, including acid, tannin, protein, and phenolic compounds. Furthermore, the extract exhibited potent anti-oxidant activity, as evidenced by its ability to scavenge free radicals and attenuate ROS-induced oxidative stress. Conclusion: The findings of this study underscore the potential of Spermacoce hispida ethanolic extract as a source of bioactive compounds with anti-inflammatory and anti-oxidant properties. The presence of phytochemicals and the observed bioactivity support its traditional use and suggest potential therapeutic applications. These results contribute to the growing body of knowledge on natural products with health-promoting effects and provide a basis for further research aimed at developing pharmaceutical and medicinal interventions harnessing the benefits of Spermacoce hispida.

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Development of Novel Nano Niosomes As Drug Delivery System of Spermacoce hispida Extract and In Vitro Antituberculosis Activity

Cited by 17 publications

References 0 publications

Treatment opportunities with Fernandoa adenophylla and recent novel approaches for natural medicinal phytochemicals as a drug delivery system

Treatment opportunities with Fernandoa adenophylla and recent novel approaches for natural medicinal phytochemicals as a drug delivery system

<p>Novel Drug Delivery Systems for Loading of Natural Plant Extracts and Their Biomedical Applications</p>

Phytochemical Screening and Anti-Inflammatory and Anti-Oxidant Activities of Spermacoce Hispida Ethanolic Extract

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