Development of novel pH-sensitive nanoparticles loaded hydrogel for transdermal drug delivery

Qindeel, Maimoona; Ahmed, Naveed; Sabir, Fakhara; Khan, Samiullah; Rehman, Asim Ur

doi:10.1080/03639045.2019.1569031

Cited by 78 publications

(47 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Later, triggered camptothecin (CPT) release at mild acid pH values was achieved by loading CPT-containing nanoparticles based on an acid-sensitive β-cyclodextrin derivative (i.e., acetalated-β-cyclodextrin) into supramolecular hydrogels prepared starting from graphene oxide and poly(vinyl alcohol) (Ye and Hu, 2016). Lastly, Qindeel et al (2019) described hybrid formulations for transdermal drug delivery resulting from the encapsulation of pH-sensitive nanoparticles into Carbopol 934-based hydrogels.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Boffito

Torchio

Tonda‐Turo

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Hybrid Hydrogels for pH-Triggered Release in rodents. Moreover, MSN-CS-SIP-Ru-loaded gels turned out to be detectable through the skin by IVIS imaging. Cargo acid pH-triggered delivery from PEU-Boc and PEU-NH 2 gels was finally demonstrated through drug release tests in neutral and acid pH environments (in acid pH environment approximately 2-fold higher cargo release). Additionally, acid-triggered payload release from PEU-NH 2 gels was significantly higher compared to PEU-Boc systems at 3 and 4 days incubation. The herein designed hybrid injectable formulations could thus represent a significant step forward in the development of multi-stimuli sensitive drug carriers. Indeed, being able to adapt their behavior in response to biochemical cues from the surrounding physio-pathological environment, these formulations can effectively trigger the release of their payload according to therapeutic needs.

show abstract

Section: Introductionmentioning

confidence: 99%

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Boffito

Torchio

Tonda‐Turo

et al. 2020

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…It has attracted wide research attentions. However, it still has some problems [67,70,74,[82][83][84][85]: firstly, the response time of temperature-sensitive hydrogel is still long to the drug carrying system. In clinical applications, temperature-sensitive hydrogels have poor hydrophilicity, low relative molecular weight, and initial sudden releasing problems of proteins.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Progress on Preparation of pH/Temperature-Sensitive Intelligent Hydrogels and Applications in Target Transport and Controlled Release of Drugs

Zheng

et al. 2021

International Journal of Polymer Science

View full text Add to dashboard Cite

Hydrogels with three-dimensional network structure, hydrophilic, and insoluble in water which are ideal carrier materials for intelligent drug delivery systems. Intelligent hydrogel has become a research frontier and hotspot because of its intelligence, high efficiency, safety, and convenience in drug controlled and prolonged release. It has a broad application prospect in the medicine and biomedicine fields and can lead the medicine fields into a new era of “precise treatment.” Based on the latest research progress, the main preparation methods of hydrogel and the development of the drug delivery system are briefly introduced. The most promising three intelligent hydrogels in the human physiological environment, namely, pH responsiveness, temperature responsiveness, and pH/temperature dual responsiveness, are emphatically reviewed. Their release mechanisms, targeting transport, and controlled-prolonged release of drug are also discussed. In addition, some suggestions for the main problems and future development were given.

show abstract

“…Therefore, the intranasal delivery of nanoparticles could be a promising choice for targeting life-threatening diseases like glioblas Q20 toma. Regarding the carrier systems, the essential classes of nanoparticles that are at the center of focus for brain targeting include polymeric nanoparticles such as micelles, iron oxide nanoparticles, gold nanoparticles, quantum dots and lipid-based nanoparticles like nano lipid carriers (NLCs), SLNs, liposomes, lipoplexes and lipopro Q21 teins [19]. In general, nanoparticles can induce toxicity depending upon their internalization site and composition.…”

Section: Nanocarrier Systems For Nose-to-brain Deliverymentioning

confidence: 99%

Nose-to-brain delivery of antiglioblastoma drugs embedded into lipid nanocarrier systems: status quo and outlook

Sabir

Ismail

Csóka

2020

Drug Discovery Today

Self Cite

View full text Add to dashboard Cite

Development of novel pH-sensitive nanoparticles loaded hydrogel for transdermal drug delivery

Cited by 78 publications

References 60 publications

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Hybrid Injectable Sol-Gel Systems Based on Thermo-Sensitive Polyurethane Hydrogels Carrying pH-Sensitive Mesoporous Silica Nanoparticles for the Controlled and Triggered Release of Therapeutic Agents

Progress on Preparation of pH/Temperature-Sensitive Intelligent Hydrogels and Applications in Target Transport and Controlled Release of Drugs

Nose-to-brain delivery of antiglioblastoma drugs embedded into lipid nanocarrier systems: status quo and outlook

Contact Info

Product

Resources

About