Development of novel pH-sensitive thiolated chitosan/PMLA nanoparticles for amoxicillin delivery to treat Helicobacter pylori

Arif, Muhammad; Dong, Qi; Raja, Mazhar Ali; Zeenat, Shah; Chi, Zhe; Liu, Chenguang

doi:10.1016/j.msec.2017.08.038

Cited by 87 publications

(39 citation statements)

References 41 publications

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“…The PEGylated PLGA was applied to load amoxicillin for subsequent formation of electrospun amoxicillin /PLGA-PEG nanofibers and the obtained nanofibers showed good antibacterial activity and cytocompatibility [ 19 ]. Amoxicillin loaded cysteine conjugated chitosan/PMLA multifunctional nanoparticles were designed and successfully fabricated, and they can be used as new promising oral drug delivery systems targeting Helicobacter pylori to increase local drug bioavailability [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Morphological, Release and Antibacterial Performances of Amoxicillin-Loaded Cellulose Aerogels

Chen

et al. 2018

Molecules

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Cellulose has been widely used in the biomedical field. In this study, novel cellulose aerogels were firstly prepared in a NaOH-based solvent system by a facile casting method. Then amoxicillin was successfully loaded into cellulose aerogels with different loadings. The morphology and structure of the cellulose aerogels were characterized using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The drug release and antibacterial activities were also evaluated. The drug release results showed that cellulose aerogels have controlled amoxicillin release performance. In vitro antibacterial assay demonstrated that the cellulose aerogels exhibited excellent antibacterial activity with the amoxicillin dose-dependent activity. Therefore, the developed cellulose aerogels display controlled release behavior and efficient antibacterial performance, thus confirming their potential for biomedical applications.

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Section: Introductionmentioning

confidence: 99%

Morphological, Release and Antibacterial Performances of Amoxicillin-Loaded Cellulose Aerogels

Chen

et al. 2018

Molecules

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“…The combination of biopolymers and synthetic polymers can produce the ideal drug delivery system with suitable biocompatibility and mechanical property. Arif et al (2018) developed pH-sensitive chitosan/PMLA nanoparticles loaded with amoxicillin for H. pylori eradication. This nanosystem was conjugated with cysteine for achieving mucoadhesive and anticoagulant properties.…”

Section: Cell-based Evaluation Of Antibacterial Nanoparticles Antibacmentioning

confidence: 99%

Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

et al. 2020

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“…14 Among them and thiolated polymers were adhering to the mucus firmly. 15 However, later, mucoadhesive nanoparticles were understood to be affecting the mucus barrier properties. 16 Currently, mucus penetrating nanoparticles were thought to be suitable carriers of drugs through GIT and other barriers where mucus plays an important role.…”

Section: Absorption Of Nanoparticlesmentioning

confidence: 99%

An overview on Pharmacokinetics of Polymeric Nanoparticles Intended for Oral Delivery

Sapavatu¹,

Chinthala²,

Jadi³

2020

JYP

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Polymeric nanoparticles are investigated as drug delivery devices to overcome physicochemical and pharmacokinetic (PK) problems. Many drugs were found to be drug-like during the pharmacological screening. However, all of them cannot make it to the market due to toxicity and poor bio-availability. The advent of nanoparticles has opened a new window of research where poorly soluble drugs are made useful. Nanoparticles have also been developed for favourable pharmacokinetics to avoid toxicity and side effects, to target the desired site of action and to provide triggered drug release. Poorly soluble drugs can be entrapped, encapsulated, coated or chemically bound in nanoparticles to deliver the drugs. Generally, in standard drug delivery, devices carry the drug until the gastrointestinal tract (GIT) and the drug is released, but the tool never expected to be entering the blood. However, in polymeric nanoparticles, sometimes the drug is being carried to the blood and the site of action. Polymeric nanoparticles release the drug in the gastrointestinal tract (GIT) or enter the GIT through various pathways to appear in the bloodstream. In this review, we discuss the fate of polymeric nanoparticles made up of biodegradable polymers after they are administered through the oral route.

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Development of novel pH-sensitive thiolated chitosan/PMLA nanoparticles for amoxicillin delivery to treat Helicobacter pylori

Cited by 87 publications

References 41 publications

Morphological, Release and Antibacterial Performances of Amoxicillin-Loaded Cellulose Aerogels

Morphological, Release and Antibacterial Performances of Amoxicillin-Loaded Cellulose Aerogels

Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

An overview on Pharmacokinetics of Polymeric Nanoparticles Intended for Oral Delivery

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