Development of novel ruthenium(ii)–arene complexes displaying potent anticancer effects in glioblastoma cells

Abstract

Two bioactive Ru(ii)-p-cymene complexes are designed, structurally analysed, and investigated for their therapeutic potential in vitro against human glioblastoma (GB) cells.

Synthesis, structure, properties, and cytotoxicity of a (quinoline)RuCp+ complex

“…5 Nevertheless, there is substantial evidence that a variety of different ruthenium complexes display anti-cancer and other biological activities. 6–8 Notably, in the context of this work, many η 5 -cyclopentadienyl and η 6 -arene complexes have shown promising biological activities. 5–19…”

“…6–8 Notably, in the context of this work, many η 5 -cyclopentadienyl and η 6 -arene complexes have shown promising biological activities. 5–19…”

“…5 Nevertheless, there is substantial evidence that a variety of different ruthenium complexes display anti-cancer and other biological activities. [6][7][8] Notably, in the context of this work, many η 5 -cyclopentadienyl and η 6 -arene complexes have shown promising biological activities. [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] Many ruthenium complexes are known to exhibit biological activities, and ruthenium(II) forms many stable cationic arene complexes.…”

CORM-3 induces DNA damage through Ru(II) binding to DNA

“…It is widely held that Ru(II) is the more cytotoxic oxidation state [ 4 ], and that the biological activity of Ru complexes depends heavily on the speciation of the complexes in solution: that is, on the chemical reactions undergone by the Ru ligands [ 2 , 3 ]. In solution, the most labile ligands tend to be halides, which dissociate rapidly to give aquated complexes [ 5 ]. Such complexes are generally found to be more soluble and more biologically active [ 6 ].…”

Rapid detection of φX-174 virus based on synchronous fluorescence of tryptophan

“…Intrinsic SF of Trp has been extensively used for many analytical applications. Among them are studying molecular mechanisms in bacteria [ 38 ] and in proteins [ 39 ], early detection of carcinoma in mice [ 40 ], and monitoring potent anticancer effects in glioblastoma cells [ 41 ].While SF methods have been demonstrated as a rapid tool for bacterial classification and identification [ 42 – 45 ], and even distinguishing between live and dead bacteria [ 46 ], to our best knowledge, no detection of viruses by intrinsic SF has been reported.…”