Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine

Tanaka, Nobuyuki; Imai, Kazunori; Okimoto, Kazuto; Ueda, Satoshi; Tokunaga, Yuji; Ohike, Atsuo; Ibuki, Rinta; Higaki, Kazutaka; Kimura, Toshikiro

doi:10.1016/j.jconrel.2005.08.024

Cited by 68 publications

(43 citation statements)

References 26 publications

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“…22,30 The drug release depends upon: adsorption through the nanoparticles matrix, diffusion through the nanoparticles matrix, particles erosion, a combined erosion and diffusion process and polymer degradation (chemical or enzymatic hydrolysis). The application of the correct mathematical model allows us to analyze about release rate, points of dissolution change and mechanisms of drug release.…”

Section: X-rays Diffraction Profile Obtained From Naproxen (A) Empmentioning

confidence: 99%

Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies

Mello¹,

Ricci-Júnior²

2011

Quím. Nova

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Recebido em 7/6/10; aceito em 10/1/11; publicado na web em 25/3/11 Nanoparticles were produced by solvent emulsification evaporation method with the following characteristics: nanometric size (238 ± 3 nm), narrow polydispersity index (0.11), negative zeta potential (-15.1 mV), good yield of the process (73 ± 1.5%), excellent encapsulation efficiency (81.3 ± 4.2%) and spherical shape. X-rays diffraction demonstrated the loss of drug crystallinity after encapsulation; however, the profile of the diffractograms of the poly-ε-caprolactone (PCL) nanoparticles was kept. Differential scanning calorimetry thermograms, correspondingly, exhibited the loss of drug melting peak and the increasing of the melting point of the PCL nanoparticles, evidencing an interaction drug-polymer. Naproxen release was low and sustained obeying the Higuchi´s kinetic. The results show that nanoparticles are promising sustained release system to the naproxen.

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Section: X-rays Diffraction Profile Obtained From Naproxen (A) Empmentioning

confidence: 99%

Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies

Mello¹,

Ricci-Júnior²

2011

Quím. Nova

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“…The release data were fitted using the mathematical models of zero order, first order, Higuchi, Hixon-Crowell, square root of mass, three seconds root of mass, and Baker-Lonsdale. Zero-order kinetics can be used to describe the drug release from several types of delivery systems such as matrix tablets for drugs with low solubility 44 and osmotic systems where drug release would be directly proportional to time. The first-order model describes the release profile from the delivery systems containing drugs dispersed in porous matrices where drugs would be released at rates proportional to the amount of drug remaining in the interior of the delivery system.…”

Section: Discussionmentioning

confidence: 99%

Nanostructured delivery system for zinc phthalocyanine: preparation, characterization, and phototoxicity study against human lung adenocarcinoma A549 cells

Soares

Oliveira²,

Santos³

et al. 2011

IJN

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In this study, zinc phthalocyanine (ZnPc) was loaded onto poly-ɛ-caprolactone (PCL) nanoparticles (NPs) using a solvent emulsification–evaporation method. The process yield and encapsulation efficiency were 74.2% ± 1.2% and 67.1% ± 0.9%, respectively. The NPs had a mean diameter of 187.4 ± 2.1 nm, narrow distribution size with a polydispersity index of 0.096 ± 0.004, zeta potential of −4.85 ± 0.21 mV, and spherical shape. ZnPc has sustained release, following Higuchi’s kinetics. The photobiological activity of the ZnPc-loaded NPs was evaluated on human lung adenocarcinoma A549 cells. Cells were incubated with free ZnPc or ZnPc-loaded NPs for 4 h and then washed with phosphate-buffered saline. Culture medium was added to the wells containing the cells. Finally, the cells were exposed to red light (660 nm) with a light dose of 100 J/cm 2 . The cellular viability was determined after 24 h of incubation. ZnPc-loaded NPs and free photosensitizer eliminated about 95.9% ± 1.8% and 28.7% ± 2.2% of A549 cells, respectively. The phototoxicity was time dependent up to 4 h and concentration dependent at 0–5 μg ZnPc. The cells viability decreased with the increase of the light dose in the range of 10–100 J/cm 2 . Intense lysis was observed in the cells incubated with the ZnPcloaded NPs and irradiated with red light. ZnPc-loaded PCL NPs are the release systems that promise photodynamic therapy use.

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“…pharmaceutical dosage form; Qr is the amount of drug remaining as a solid state at time t; Mt/M ∞ is the fraction of drug released; K 1 , K H and K S are, respectively the first order, the Higuchi's and the Hixson-Crowell's release constants; and n the release exponent that indicates of the mechanism of release. [35][36][37][38][39][40] The Hixson-Crowell model assumes that the drug release is limited by the dissolution rate of the particles, and not by diffusion through the polymer matrix, 37 and the Higuchi model able to describe the release of soluble or poorly soluble drug in water from a semi-solid or solid matrix system. 35 Therefore, the value of n was used by Peppas 40 in order to characterize the various release mechanisms.…”

Section: Release Mechanisms and Mathematical Analysismentioning

confidence: 99%

Elaboration of Microspheres’ Capsules Based on Ethylcellulose and Synthesized Poly (Butylsuccinate) as Biodegradable Matrices for Drug Delivery of an Antithyroidian Agent

Chirani¹,

Lebig²,

Bouameur³

et al. 2017

IJPER

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Introduction:The present paper provides details of preparation of hardcapsules based on microspheres containing 2-aminothiazole as an antithyroidian agent and synthesized poly(butylsuccinate) (PBS) or ethylcellulose(EC10) as biodegradable matrices as well as the study of the drug delivery. Methods: A disintegration tests of these gelatinous capsules were done. The biodegradable synthesized polyester was characterized by infrared spectroscopy, nuclear magnetic resonance (mono and bidimentional H1NMR, 13CNMR) and by Differential Scanning Calorimetry (DSC). A viscosimetric study has been done in order to evaluate viscosimetric PBS's weight wich was calculated from Mark-Houwink equation. The microencapsulation of 2-aminothiazole was done using solvent evaporation technique. Results: Microspheres were spherical and the effects of varying emulsifiers and blades number on microspheres encapsulation efficiency were evaluated. A kinetic studies of releases of 2-aminothiazole in gastric pH were done in order to evaluate the best late effect and then the best formulation.

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Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine

Cited by 68 publications

References 26 publications

Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies

Encapsulation of naproxen in nanostructured system: structural characterization and in vitro release studies

Nanostructured delivery system for zinc phthalocyanine: preparation, characterization, and phototoxicity study against human lung adenocarcinoma A549 cells

Elaboration of Microspheres’ Capsules Based on Ethylcellulose and Synthesized Poly (Butylsuccinate) as Biodegradable Matrices for Drug Delivery of an Antithyroidian Agent

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