Development of Novel Therapy for Oral Diseases Using Kampo Medicines

Ara, Toshiaki; Hattori, Tsuyoshi; Imamura, Yasuhiro; Wang, Pao-Li

doi:10.1016/s1349-0079(10)80038-6

Cited by 8 publications

(4 citation statements)

References 32 publications

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“…It has been reported that osteoblasts infected with Brucella produced pro-inflammatory cytokines, secreted IL-8, mobilized phagocytic cells to the site of infection, and initiated an inflammatory response [44]. Combined with the findings of our previous studies [7,8,18,19], the present findings suggest that hainosankyuto possesses anti-inflammatory effects against periodontitis along with osteoblast activation effects. In summary, we demonstrated the effect of hainosankyuto in vitro on anti-inflammatory cytokines, type I collagen, and ALP activity in Saos-2 cells.…”

Section: Discussionsupporting

confidence: 83%

“…Previously, we established a human gingival fibroblast culture stimulated with a lipopolysaccharide (LPS), an endotoxin of the periodontitis‐associated bacteria Porphyromonas gingivalis [18]. Using this system as an in vitro cellular model of periodontal disease, we elucidated the efficacy of various herbal medicines, including shosaikoto, orento, orengedokuto, hangeshashinto, hochuekkito, and hainosankyuto, for the treatment of periodontitis [19].…”

Section: Introductionmentioning

confidence: 99%

“…Our cell culture experiments [19] and animal experiments [20] demonstrated the anti‐inflammatory effect of hainosankyuto on periodontal disease. This disease affects periodontal tissues, such as the gingiva and alveolar bone, due to inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Anti‐inflammatory effect and bone induction ability of hainosankyuto in the human osteosarcoma cell line Saos‐2

Wang

Makita

Masuno

et al. 2021

Traditional & Kampo Medicine

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Aim Hainosankyuto is a traditional Japanese medicine known as Kampo. It is mainly used to treat skin pain and mucosal suppurative diseases. Hainosankyuto also alleviates pain resulting from local reddening and swelling and promotes pus discharge. Our previous cell culture and animal experiments demonstrated the anti‐inflammatory effect of hainosankyuto on periodontal disease (Kampo Med. 45, 601–607, 2018). Periodontal disease affects periodontal tissues, such as the gingiva and alveolar bone, due to inflammation. Our study aimed to evaluate the anti‐inflammatory effects of hainosankyuto on osteoblasts and assess whether this medicine affects their bone‐forming ability. Methods We examined the effect of hainosankyuto on the proliferation of the human osteosarcoma cell line Saos‐2 in vitro using 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide and DNA synthesis assays. We also evaluated its effect on interleukin (IL)‐8, type 1 collagen, and alkaline phosphatase (ALP) activity in these cells using enzyme‐linked immunosorbent assays and ALP assay. Results Hainosankyuto (1000 μg/mL) significantly induced Saos‐2 cell proliferation, suppressed IL‐8 production, and enhanced type 1 collagen production and ALP activity. Conclusion These results indicate that hainosankyuto regulates inflammation and metabolism in osteoblasts, resulting in the activity of early bone‐related biomarkers.

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Section: Discussionsupporting

confidence: 83%

Section: Introductionmentioning

confidence: 99%

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Anti‐inflammatory effect and bone induction ability of hainosankyuto in the human osteosarcoma cell line Saos‐2

Wang

Makita

Masuno

et al. 2021

Traditional & Kampo Medicine

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“…AQP3 promotes keratinocyte proliferation and differentiation [32] , and facilitates wound healing [32,33] . Byakkokaninjinto and goreisan enhances salivary secretion [34,35] . In fact, Byakkokaninjinto activates muscarinic acetylcholine receptor M3 [34] , and it increases the expression of AQP 5 [34] , which regulates salivary secretion .…”

Section: Etiopathogenesis Of Intractable Stomatitis and The Action Mementioning

confidence: 99%

Effectiveness of Kampo Medicines Against Intractable Stomatitis: A Mini-Review

Momota

Takano

Azuma

2019

International Journal of Medical and Dental Sciences

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Intractable stomatitis is a chronic inflammatory disease of oral mucosa, with unclear etiopathogenesis. Kampo Medicines (KMs), i.e., Japanese herbal medicines, effectively treat stomatitis. The precise effects of KMs on intractable stomatitis are not established. We present the details of several patients with intractable stomatitis who were well-treated with KMs (i.e., Inchinkoto, Orento, Goreisan, and Byakkokaninjinto). We also review the literature on the link between intractable stomatitis and KMs. KM-related anti-inflammatory and antioxidant activity may suppress intractable stomatitis. KMs may also facilitate wound healing through increased saliva secretion. KMs may therefore be useful for the treatment of intractable stomatitis.

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Plants and other natural products used in the management of oral infections and improvement of oral health

Chinsembu

2016

Acta Tropica

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Development of Novel Therapy for Oral Diseases Using Kampo Medicines

Cited by 8 publications

References 32 publications

Anti‐inflammatory effect and bone induction ability of hainosankyuto in the human osteosarcoma cell line Saos‐2

Anti‐inflammatory effect and bone induction ability of hainosankyuto in the human osteosarcoma cell line Saos‐2

Effectiveness of Kampo Medicines Against Intractable Stomatitis: A Mini-Review

Plants and other natural products used in the management of oral infections and improvement of oral health

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