Development of Novel Warfarin-Silica Composite for Controlled Drug Release

Parfenyuk, Elena V.; Dolinina, Ekaterina S.

doi:10.1007/s11095-017-2111-9

Cited by 12 publications

(8 citation statements)

References 37 publications

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“…The ATR-IR spectra of pure substances, physical mixtures as well as OPS, drug-loaded and placebo EXT and IJP ODFs are presented in Figure 10. The physical mixture of HPC and the drug showed bands attributed to HPC (3431 cm –1 , 2969 cm –1 ) [58] as well as WS (1663 cm –1 , 1453 cm –1 , 1323 cm –1 , 1720 cm –1 , 759 cm –1 and 704 cm –1 ) [32,59,60]. For the drug-loaded EXT ODF, similar bands as to pure WS were seen at 1326 cm –1 , 701 cm –1 , 760 cm –1 , and the broad peak characteristic for pure HPC was present at 3600–3100 cm –1 [61].…”

Section: Resultsmentioning

confidence: 99%

Towards Printed Pediatric Medicines in Hospital Pharmacies: Comparison of 2D and 3D-Printed Orodispersible Warfarin Films with Conventional Oral Powders in Unit Dose Sachets

et al. 2019

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To date, the lack of age-appropriate medicines for many indications results in dose manipulation of commercially available dosage forms, commonly resulting in inaccurate doses. Various printing technologies have recently been explored in the pharmaceutical field due to the flexible and precise nature of the techniques. The aim of this study was, therefore, to compare the currently used method to produce patient-tailored warfarin doses at HUS Pharmacy in Finland with two innovative printing techniques. Dosage forms of various strengths (0.1, 0.5, 1, and 2 mg) were prepared utilizing semisolid extrusion 3D printing, inkjet printing and the established compounding procedure for oral powders in unit dose sachets (OPSs). Orodispersible films (ODFs) drug-loaded with warfarin were prepared by means of printing using hydroxypropylcellulose as a film-forming agent. The OPSs consisted of commercially available warfarin tablets and lactose monohydrate as a filler. The ODFs resulted in thin and flexible films showing acceptable ODF properties. Moreover, the printed ODFs displayed improved drug content compared to the established OPSs. All dosage forms were found to be stable over the one-month stability study and suitable for administration through a naso-gastric tube, thus, enabling administration to all possible patient groups in a hospital ward. This work demonstrates the potential of utilizing printing technologies for the production of on-demand patient-specific doses and further discusses the advantages and limitations of each method.

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Section: Resultsmentioning

confidence: 99%

Towards Printed Pediatric Medicines in Hospital Pharmacies: Comparison of 2D and 3D-Printed Orodispersible Warfarin Films with Conventional Oral Powders in Unit Dose Sachets

et al. 2019

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“…Reference source not found.. ATR-FTIR spectrum of pure warfarin showed the following characteristic sharp intense bands; the stretching of lactone C=O bond is observed at 1681 cm -1 , the asymmetric bending vibrations of CH3 group are observed at 1451 cm -1 and the out-of-plane bending vibrations of C-H of phenyl rings are observed at 762 cm -1 . The band at 1223 cm -1 can be attributed to the hemiketal hydroxyl in-plane bending vibration (35). Noticeably, for warfarin-HPMC spray dried and printed films, vibrational bands with lower intensities and minor shifts of C-H of phenyl (760 cm -1 ) and CH3 (1451 cm-1 ) were observed.…”

Section: Resultsmentioning

confidence: 94%

Personalisation of warfarin therapy using thermal ink-jet printing

Vuddanda

Alomari

Dodoo

et al. 2018

European Journal of Pharmaceutical Sciences

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Warfarin is a widely used anticoagulant that is critical in reducing patient morbidity and mortality associated with thromboembolic disorders. However, its narrow therapeutic index and large inter-individual variability can lead to complex dosage regimes. Formulating warfarin as an orodispersible film (ODF) using thermal ink-jet (TIJ) printing could enable personalisation of therapy to simplify administration. Commercial TIJ printers are currently unsuitable for printing the milligram dosages, typically required for warfarin therapy. As such, this study aimed to modify a commercial TIJ printing system to formulate personalised warfarin ODFs containing therapeutic dosages. A TIJ printer was modified successfully with the printer functionality intact; the substrate (paper) rolling mechanism of the printer was replaced by printing onto a stationary stage. Free film substrates were composed of hydroxypropyl methylcellulose (20%w/w) and glycerol (3%w/w). The resulting ODFs were characterised for morphology, disintegration, solid-state properties and drug content. Printed film stability was assessed at 40 °C/75% relative humidity for 30 days. Therapeutic warfarin doses (1.25 and 2.5 mg) were successfully printed onto the film substrates. Excellent linearity was observed between the theoretical and measured dose by changing the warfarin feed concentration (R = 0.9999) and length of the print objective, i.e. the Y-value, (R = 0.9998). Rapid disintegration of the ODFs was achieved. As such, this study successfully formulated personalised warfarin ODFs using a modified TIJ printer, widening the range of applications for TIJ printing to formulate narrow therapeutic index drugs.

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“…An innovative warfarin-silica composite was designed by Parfenyuk et al [95] for managed drug release using the sol-gel processing method. The kinetic parameters and release mechanisms for both drugs are identical in general.…”

Section: Silica Composite Drug Carriersmentioning

confidence: 99%