Development of Oil-in-Gelatin Phantoms for Viscoelasticity Measurement in Ultrasound Shear Wave Elastography

Nguyen, Minh; Zhou, Shiwei; Robert, Jean-Luc; Shamdasani, Vijay; Xie, Hua

doi:10.1016/j.ultrasmedbio.2013.08.020

Cited by 66 publications

(58 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…4(b) not only show the wave attenuation but also the elastic wave dispersion. The increased width of the elastic wave is well correlated to viscosity by the Voigt model [26]. The elasticity of the chicken breast estimated by OCE was 4.7 ± 1.1 kPa, which is similar to 5.1 ± 1.1 kPa obtained by mechanical compressional testing as plotted in Fig.…”

Section: Chicken Breast Muscle Mechanical Anisotropysupporting

confidence: 82%

Non-contact single shot elastography using line field low coherence holography

Liu

Schill

et al. 2016

Biomed. Opt. Express

View full text Add to dashboard Cite

Optical elastic wave imaging is a powerful technique that can quantify local biomechanical properties of tissues. However, typically long acquisition times make this technique unfeasible for clinical use. Here, we demonstrate non-contact single shot elastographic holography using a line-field interferometer integrated with an air-pulse delivery system. The propagation of the air-pulse induced elastic wave was imaged in real time, and required a single excitation for a line-scan measurement. Results on tissuemimicking phantoms and chicken breast muscle demonstrated the feasibility of this technique for accurate assessment of tissue biomechanical properties with an acquisition time of a few milliseconds using parallel acquisition.

show abstract

Section: Chicken Breast Muscle Mechanical Anisotropysupporting

confidence: 82%

Non-contact single shot elastography using line field low coherence holography

Liu

Schill

et al. 2016

Biomed. Opt. Express

View full text Add to dashboard Cite

show abstract

“…Above 10% castor oil, λ exp decreases monotonically for increasing castor oil concentrations. While this finding was unexpected, Nguyen et al reported a similar trend between absolute sound speed and castor oil concentration suggesting that our measurement might be a consistent physical phenomena resulting from low concentrations of oil in gelatin (Nguyen et al 2014b). …”

Section: Resultssupporting

confidence: 74%

“…The phantom fabrication technique was modified from a recipe previously reported in the literature (Nguyen et al 2014b). The respective volumes of water and sulphonated castor oil (Spectrum Chemical, CA, USA) were first calculated in order to obtain a castor oil percentage ranging from 0 – 50% (vol/vol).…”

Section: Methodsmentioning

confidence: 99%

Improved Estimation of Ultrasound Thermal Strain Using Pulse Inversion Harmonic Imaging

Ding

Nguyen

James

et al. 2016

Ultrasound in Medicine & Biology

Self Cite

View full text Add to dashboard Cite

Thermal (temporal) strain imaging (TSI) is being developed to detect the lipid rich core of atherosclerotic plaques and fatty liver disease. However, the effects of ultrasonic clutter on TSI have not been considered. In this study, we evaluated whether pulse inversion harmonic imaging (PIHI) could be used to improve estimates of thermal (temporal) strains. Using mixed castor oil-gelatin phantoms of different concentrations and artificially introduced clutter, we showed that PIHI improved the signal-to-noise ratio of TSI by an average of 213% or 52.1% as compared to 3.3 MHz and 6.6 MHz imaging. In a phantom constructed using human liposuction fat in the presence of clutter, the contrast-to-noise ratio was degraded by 35.1% for PIHI as compared to 62.4% and 43.7% for 3.3 MHz and 6.6 MHz imaging, respectively. These findings were further validated using an ex vivo carotid endarterectomy sample. PIHI can be used to improve estimates of thermal (temporal) strain in the presence of clutter.

show abstract

“…6(b)]. This variability is commonly attributed to jitter in the ultrasound-based displacement estimates [39], [43] and more recently thought to be caused by speckle-induced bias (i.e., preferential tracking of bright or constructively interfering speckle within an ultrasound tracking beam) [44]. The second potential source of error is the response time of the robot [determined by the tuning parameters in (2)], which was not adjusted to account for the high-frequency cardiovascular induced motion of abdominal organs [45].…”

Section: Discussionmentioning

confidence: 99%

“…The phantom fabrication process was a modified version of previously reported methods [38], [39]. Our nonlinear phantom was composed of 250-bloom A-type gelatin (19 g), agar (0.93 g), deionized water (285 mL), graphite (17 g), ethanol (30.3 mL), and 3% formaldehyde diluted with water (3.2 mL).…”

Section: Methodsmentioning

confidence: 99%

Toward Standardized Acoustic Radiation Force (ARF)-Based Ultrasound Elasticity Measurements With Robotic Force Control

Bell

Kumar

Kuo

et al. 2016

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

Objective Acoustic radiation force (ARF)-based approaches to measure tissue elasticity require transmission of a focused high-energy acoustic pulse from a stationary ultrasound probe and ultrasound-based tracking of the resulting tissue displacements to obtain stiffness images or shear wave speed estimates. The method has established benefits in biomedical applications such as tumor detection and tissue fibrosis staging. One limitation, however, is the dependence on applied probe pressure, which is difficult to control manually and prohibits standardization of quantitative measurements. To overcome this limitation, we built a robot prototype that controls probe contact forces for shear wave speed quantification. Methods The robot was evaluated with controlled force increments applied to a tissue-mimicking phantom and in vivo abdominal tissue from three human volunteers. Results The root-mean-square error between the desired and measured forces was 0.07 N in the phantom and higher for the fatty layer of in vivo abdominal tissue. The mean shear wave speeds increased from 3.7 to 4.5 m/s in the phantom and 1.0 to 3.0 m/s in the in vivo fat for compressive forces ranging from 2.5 to 30 N. The standard deviation of shear wave speeds obtained with the robotic approach were low in most cases (< 0.2 m/s) and comparable to that obtained with a semiquantitative landmark-based method. Conclusion Results are promising for the introduction of robotic systems to control the applied probe pressure for ARF-based measurements of tissue elasticity. Significance This approach has potential benefits in longitudinal studies of disease progression, comparative studies between patients, and large-scale multidimensional elasticity imaging.

show abstract

Development of Oil-in-Gelatin Phantoms for Viscoelasticity Measurement in Ultrasound Shear Wave Elastography

Cited by 66 publications

References 29 publications

Non-contact single shot elastography using line field low coherence holography

Non-contact single shot elastography using line field low coherence holography

Improved Estimation of Ultrasound Thermal Strain Using Pulse Inversion Harmonic Imaging

Toward Standardized Acoustic Radiation Force (ARF)-Based Ultrasound Elasticity Measurements With Robotic Force Control

Contact Info

Product

Resources

About