Development of open-field activity in the rat following caudate lesions in infancy

Johnson, David A.; Becker, Thomas

doi:10.3758/bf03334361

Cited by 7 publications

(3 citation statements)

References 10 publications

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“…Several other investigators have reported increased activity following dorsal caudate lesions in males (Baettig, 1963;Johnson & Becker, 1973;Kirkby, 1973;Schmaltz & Isaacson, 1972;Whittier & Orr, 1962), and our failure to observe comparable effects may seem surprising. Three factors may account for this discrepancy.…”

Section: Discussioncontrasting

confidence: 72%

“…Finally, differences in lesion size and location are probably important; for example, the lesions in the Kirkby (1973) experiment were larger than in ours and also tended to be laterally asymmetrical. Lesion symmetry could be important because Johnson and Becker (1973) reported that unilateral caudate lesions were more effective than bilateral lesions in increasing open-field activity. Kemble et al (1976) reported that dorsal caudate lesions depressed rearing by male rats during open-field tests.…”

Section: Discussionmentioning

confidence: 99%

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Open-field and avoidance behavior after neostriatal lesions in male and female rats.

Studelska¹,

Beatty²

1978

Journal of Comparative and Physiological Psychology

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The behavioral effects of lesions of the anterodorsal or posteroventral parts of the caudate-putamen were studied in adult male and female rats that were gonadectomized or left untreated prior to brain surgery, Anterodorsal (ADC) lesions consistently impaired acquistion of one-way avoidance behavior and tended to interfere with the development of a two-way avoidance response; comparable effects were observed in gonadectomized and intact animals of both sexes. By contrast, ADC lesions increased activity in the open field only in intact females and increased rearing only in ovariectomized females. Posteroventral caudate (PVC) lesions caused transient aphagia and adipsia in both sexes but did not consistently affect open-field activity or the acquistion of one-way avoidance responses by either sex. These lesions profoundly impaired acquistion of shuttle box avoidance responses by intact males. By contrast, castrated males and intact and ovariectomized females with PVC lesions avoided normally in the shuttle box. The present results suggest that localization of behavioral functions within the striatum differs with the sex of the subject, in part because of activational effects of gonadal hormones.A number of recent experiments have examined the effects of localized lesions in the caudate nucleus on active avoidance behavior in the rat. There is general agreement that both dorsal and ventral caudate lesions produce deficits in the acquisition of twoway active avoidance behavior (Kirkby & Polgar, 1974;Mitcham & Thomas, 1972;Neill & Grossman, 1970;Winocur, 1974) and that ventral caudate lesions impair acquisition of one-way active avoidance responding (Kirkby & Polgar, 1974;Winocur, 1974). However, the effects of dorsal caudate lesions on one-way avoidance are not yet clear. Winocur (1969Winocur ( , 1974 observed no impairment in the acquisition of the one-way task following dorsal caudate lesions, whereas Kirkby and Polgar (1974) found that dorsal caudate lesions were at least as effective as ventral caudate lesions in retarding acquisition of a one-way avoidance response.The effects of caudate lesions on open-

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Section: Discussioncontrasting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Open-field and avoidance behavior after neostriatal lesions in male and female rats.

Studelska¹,

Beatty²

1978

Journal of Comparative and Physiological Psychology

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“…Some sparing has been reported after damage during infancy to the hippocampus (Isaacson et al, 1968;Molino, 1975) and to the ventromedial hypothalamus (Bernardis & Frohman, 1970Frohman & Bernardis, 1968;Green, 1967), but many functions associated with these structures are totally disrupted by early damage. There has been no discernible advantage attributable to infantile destruction of the caudate nucleus (Goldman & Rosvold, 1972;Johnson & Becker, 1973), the septal area (Johnson, 1972;Molino, 1975), the lateral hypothalamus (Almli & Golden, 1974), or the dorsomedial nucleus of the thalamus (Goldman, 1974). The absence in the present study of any preferential recovery after removal of the amygdala during infancy thus is consistent with a growing body of literature which suggests that subcortical brain damage in infancy typically results in little sparing of function.…”

Section: Discussionmentioning

confidence: 99%

Social and nonsocial behaviors of adult rhesus monkeys after amygdalectomy in infancy or adulthood.

Thompson

Bergland²,

Towfighi³

1977

Journal of Comparative and Physiological Psychology

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At 6 yr of age six female rhesus monkeys that had sustained bilateral amygdalectomy in infancy, and five intact controls, were transferred to an observation cage where behaviors were recorded while the monkeys were (a) alone, (b) paired with unfamiliar stimulus animals, and (c) paired with familiar monkeys from the opposite experimental group. The five adult controls then underwent amygdalectomy, and all tests were repeated with the infant-and adult-operated animals. Infant-operated monkeys changed behaviors more rapidly than did intact controls in social and nonsocial situations, and their activity levels were less modified after a 24-hr period in the observation cage. They were subordinate to intact controls but expressed less fear than did controls when briefly placed with an unfamiliar aggressive animal. Adult amygdalectomy produced many changes in behavior, but these aberrations were identical to those observed in like-age monkeys that had been amygdalectomized in infancy. Infant-operated monkeys demonstrated more behavioral deficits at 6 yr than they had earlier in life.

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Age, Brain Damage, and Performance

Johnson

Almli

1978

Recovery From Brain Damage

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Development of open-field activity in the rat following caudate lesions in infancy

Cited by 7 publications

References 10 publications

Open-field and avoidance behavior after neostriatal lesions in male and female rats.

Open-field and avoidance behavior after neostriatal lesions in male and female rats.

Social and nonsocial behaviors of adult rhesus monkeys after amygdalectomy in infancy or adulthood.

Age, Brain Damage, and Performance

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