Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

Li, Jingchao; Pu, Kanyi

doi:10.1039/c8cs00001h

Cited by 1,016 publications

(640 citation statements)

References 276 publications

(226 reference statements)

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“…[32,83] PAI provides the high soft tissue contrast that is highlighted in LN mapping. [85] Organic semiconducting NMs with the advantages in biocompatibility and biodegradability can be potentially translated from laboratory to clinic. [85] Organic semiconducting NMs with the advantages in biocompatibility and biodegradability can be potentially translated from laboratory to clinic.…”

Section: Mapping Sentinel Lymph Nodes (Slns) For Surgerymentioning

confidence: 99%

“…[135,136] PAI takes advantage of the synergistic action of the high contrast and specificity of optical imaging, and the deep tissue penetration, high spatial resolution, and 3D image of ultrasonic imaging, [83,85,137] thereby making it attractive for IGS. [135,136] PAI takes advantage of the synergistic action of the high contrast and specificity of optical imaging, and the deep tissue penetration, high spatial resolution, and 3D image of ultrasonic imaging, [83,85,137] thereby making it attractive for IGS.…”

Section: Paimentioning

confidence: 99%

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Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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Surgical resection is the primary and most effective treatment for most patients with solid tumors. However, patients suffer from postoperative recurrence and metastasis. In the past years, emerging nanotechnology has led the way to minimally invasive, precision and intelligent oncological surgery after the rapid development of minimally invasive surgical technology. Advanced nanotechnology in the construction of nanomaterials (NMs) for precision imaging-guided surgery (IGS) as well as surgery-assisted synergistic therapy is summarized, thereby unlocking the advantages of nanotechnology in multimodal IGS-assisted precision synergistic cancer therapy. First, mechanisms and principles of NMs to surgical targets are briefly introduced. Multimodal imaging based on molecular imaging technologies provides a practical method to achieve intraoperative visualization with high resolution and deep tissue penetration. Moreover, multifunctional NMs synergize surgery with adjuvant therapy (e.g., chemotherapy, immunotherapy, phototherapy) to eliminate residual lesions. Finally, key issues in the development of ideal theranostic NMs associated with surgical applications and challenges of clinical transformation are discussed to push forward further development of NMs for multimodal IGS-assisted precision synergistic cancer therapy.

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Section: Mapping Sentinel Lymph Nodes (Slns) For Surgerymentioning

confidence: 99%

Section: Paimentioning

confidence: 99%

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

et al. 2019

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“…As well documented, the second near‐infrared (NIR‐II) fluorescence imaging has better performance than the visible and the traditional near‐infrared (NIR‐I) imaging in in vivo imaging, due to its higher resolution, deeper signal penetration in tissues, and lower tissue autofluorescence . For fully exerting the effects of NIR‐II imaging, high‐performance NIR‐II fluorophores are necessary.…”

Section: Introductionmentioning

confidence: 99%

“…As an example, polymethine NIR‐II dyes can exhibit significantly different absorption and emission bands and quantum yields (QYs) when their conjugated polymethine length and/or heteroaromatic moieties are changed, which is reflected by the optical properties of reported polymethine NIR‐II dyes as well as commercially available cyanine dye IR 1050 and thiopyrilium dyes IR 1061 and IR 26 . For donor‐acceptor‐donor (D‐A‐D) type NIR‐II dyes, different donor and acceptor moieties provide significantly different emission properties …”

Section: Introductionmentioning

confidence: 99%

Improving Quantum Yield of a NIR‐II Dye by Phenylazo Group

Zhang

Liu

Zhou

et al. 2020

Adv Healthcare Materials

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Understanding structure‐fluorescence correlation is very helpful for the design of fluorescent probes. In this paper, a donor‐acceptor‐donor (D‐A‐D) type NIR‐II fluorophore with benzobisthiadiazole as the acceptor and triphenyl amine as the donor, and its three derivatives bearing respectively amino, tert‐butyloxycarbonyl amino and phenylazo groups in donor moieties, are synthesized. Their electronic structures and optical properties are investigated via theoretical and experimental studies. It is found that all the three types of substituents significantly influence its fluorescent properties and the phenylazo groups dramatically enhance its quantum yield (QY). To achieve biological applications and maintain high QY in aqueous environments, the phenylazo‐containing fluorophore is encapsulated in polystyrene‐co‐poly(ethylene glycol) micelles. The obtained fluorescent micelles have a QY of ≈3.51% in 1000–1500 nm in aqueous medium that is among the highest of the organic NIR‐II probes reported so far for biological imaging. The high QY enables the in vivo imaging of the micelle‐administered mice to be conducted with high speed and quality. As an application example, ultrafast NIR‐II imaging of intravenously injected mice is performed and used to determine their cardiac cycle and heart rate. The micelles also significantly accumulate in tumors after tail‐vein injection and exhibit great application potentials in tumor detection.

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“…Biosensing and bioimaging enable the study of biological and pathological processes in living systems at the molecular level, thus providing the opportunities for the early diagnosis of diseases and the development of innovative medicine . As a key component in the transduction of molecular/cellular events into detectable signals, molecular probes and sensors are essential.…”

mentioning

confidence: 99%

Biosensors and Bioimaging

2019

ChemBioChem

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Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation

Abstract: Recent progress in developing organic semiconducting materials (OSMs) for deep-tissue optical imaging, cancer phototherapy and biological photoactivation is summarized.

Cited by 1,016 publications

References 276 publications

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Advanced Nanotechnology Leading the Way to Multimodal Imaging‐Guided Precision Surgical Therapy

Improving Quantum Yield of a NIR‐II Dye by Phenylazo Group

Biosensors and Bioimaging

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