Development of outcome criteria to measure effectiveness of antiepileptic therapy in children

Murugupillai, Roshini; Ranganathan, Shalini Sri; Wanigasinghe, Jithangi; Muniyandi, Ravi; Arambepola, Carukshi

doi:10.1016/j.yebeh.2017.12.011

Cited by 17 publications

(28 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We did not have enough time during our face‐to‐face meeting to undertake a ranking task. The COMET handbook identifies examples of where ranking has been used as well as a recent study from the COMET database conducted in Sri Lanka that used a ranking method …”

Section: Discussionmentioning

confidence: 99%

“…The COMET database included a study conducted in Sri Lanka that has developed outcome criteria to measure effectiveness of antiepileptic therapy in children, which included young people with epilepsy as one of the stakeholder groups . The study was published while we were in the process of conducting our study.…”

Section: Discussionmentioning

confidence: 99%

“…For example, their work included outcomes such as frequency of seizures, severity of seizures, seizure freedom, cognitive function, activities that children like to do, school attendance, behavior, and quality of life, which map well onto the COS we propose. Interestingly, they ranked their outcomes with frequency of seizures being most important, followed by quality of life, which might suggest that seizures affect QoL …”

Section: Discussionmentioning

confidence: 99%

“…The COMET handbook 25 identifies examples of where ranking has been used [32][33][34] as well as a recent study from the COMET database conducted in Sri Lanka that used a ranking method. 10 Our COS captured commonly reported items such as "seizure frequency" consistent with existing guidelines. 11 However, in contrast, our COS highlights non-seizure-related outcomes such as "school attendance" (attending school and engaging in school curriculum) and "feelings about epilepsy" (emotions or reactions to having epilepsy such as embarrassment or stigma) agreed as critical for inclusion in the COS. All COS outcomes and their definitions are in Table 1.…”

Section: Discussionmentioning

confidence: 99%

“…The Core Outcome Measures in Effectiveness Trials (COMET) Initiative database recently added a study focused on West syndrome 9 and a study conducted in Sri Lanka on the development of outcome criteria to measure effectiveness of antiepileptic medication. 10 The National Institute for Health Care and Excellence guidelines recommend seizure freedom as a primary outcome alongside seizure reduction, quality of life, and cognitive functioning as secondary outcomes. 11 Cochrane reviewers advise focusing on longer-term outcomes such as psychosocial and health economic outcomes.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Core Health Outcomes in Childhood Epilepsy (CHOICE): Development of a core outcome set using systematic review methods and a Delphi survey consensus

et al. 2019

View full text Add to dashboard Cite

Objective Establishing a core set of outcomes to be evaluated and reported in intervention trials aims to improve the usefulness of health research. There is no established core outcome set (COS) for childhood epilepsies. The aim of this study was to select a COS to be used in evaluative research of interventions for children with rolandic epilepsy (RE). Methods We followed guidance from the COMET (Core Outcome Measures in Effectiveness Trials) Initiative. First, we identified outcomes that had been measured in research through a systematic review. Second, young people with RE, parents, and professionals were invited to take part in a Delphi survey in which participants rated the importance of candidate outcomes. Last, a face‐to‐face meeting was convened to seek consensus on which outcomes were critical to include and to ratify the final COS. Results From 37 eligible papers in the review, we identified and included 48 candidate outcomes in the survey. We sent invitations to 165 people registered to take part in the survey; of these, 102 (62%) completed Round 1, and 80 (78%) completed Round 2 (three young people, 16 parents, 61 professionals). In Round 2 we included four additional outcomes suggested by participants in Round 1. The consensus meeting included two young people, four parents, and nine professionals who were eligible to vote and ratified the COS as 39 outcomes across 10 domains. Significance Our methodology was a proportionate and pragmatic approach toward producing a COS for evaluating research on interventions aiming to improve the health of children with RE.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Core Health Outcomes in Childhood Epilepsy (CHOICE): Development of a core outcome set using systematic review methods and a Delphi survey consensus

et al. 2019

View full text Add to dashboard Cite

show abstract

Effect of Cannabidiol on Interictal Epileptiform Activity and Sleep Architecture in Children with Intractable Epilepsy: A Prospective Open-Label Study

et al. 2021

View full text Add to dashboard Cite

Background Cannabidiol has been shown to be effective in seizure reduction in patients with Dravet syndrome, Lennox-Gastaut syndrome, and tuberous sclerosis. However, very little is known about its potential to reduce interictal epileptiform activity and improve sleep architecture. Objective The objective of this prospective study was to evaluate the influence of cannabidiol therapy on the frequency of interictal epileptiform discharges (IEDs) and sleep microstructure in a cohort of children with drug-resistant epilepsy. Methods Children with drug-resistant epilepsy were prospectively followed from November 2019 to January 2021 during an open-label trial of cannabidiol at a dose of 20 mg/kg/day (to a maximum of 50 mg/kg/day) and stable concomitant medication. Electroencephalograms were recorded at baseline (T0) and after 3 months (T1). Two independent raters, blinded to clinical outcome, evaluated 5-min segments of sleep stage 2 or low-noise awake state. IEDs were visually identified and rates per minute calculated. Sleep microstructure was considered improved if sleep structures were seen at T1 that were not present at T0. IED rates at T0 and T1 were compared and correlated with seizure outcome, cannabidiol dose, initial IED rate, and disease duration. Results In total, 35 children (mean ± standard deviation age 10.1 ± 0.86) were included. The IED rate at T1 was significantly lower than at T0 (19.6 ± 19.5 vs. 36.8 ± 27.2, respectively; p < 0.0001). We found a moderate correlation between IED reduction and percentage of seizure reduction compared with baseline (Pearson's r = 0.39; p = 0.02), a moderate negative correlation between IED reduction and IED rate at T0 (r = − 0.34; p = 0.04), and a trend towards a moderate negative correlation between IED reduction and disease duration (r = − 0.32; p = 0.06). Sleep was recorded in 23 patients. Sleep microstructure was initially abnormal in 56.5% of sleep recordings and improved in 84.6% of those cases. Conclusion Our results strongly suggest the utility of cannabidiol in reducing IEDs and improving sleep microstructure in children with drug-resistant epilepsy. Larger controlled studies are needed to evaluate the clinical relevance of this effect in different epilepsy types.

show abstract

Current status and implementation strategies of patient education in core outcome set development

Wu,

Yu,

Huang

et al. 2024

Patient Education and Counseling

View full text Add to dashboard Cite

Development of outcome criteria to measure effectiveness of antiepileptic therapy in children

Cited by 17 publications

References 20 publications

Core Health Outcomes in Childhood Epilepsy (CHOICE): Development of a core outcome set using systematic review methods and a Delphi survey consensus

Core Health Outcomes in Childhood Epilepsy (CHOICE): Development of a core outcome set using systematic review methods and a Delphi survey consensus

Effect of Cannabidiol on Interictal Epileptiform Activity and Sleep Architecture in Children with Intractable Epilepsy: A Prospective Open-Label Study

Current status and implementation strategies of patient education in core outcome set development

Contact Info

Product

Resources

About