Development of P-on-N silicon photomultiplier prototype for blue light detection

Abstract

In this paper, we report a preliminary study on the electrical and optical properties of the first P-on-N SiPM prototype developed at KAIST with a collaboration of NNFC. The sensors were fabricated on a 200 mm n-type silicon epitaxial-layer wafer via customized CMOS process at NNFC. Measurements on the reverse current were carried out on a wafer-level with an auto-probing station and breakdown voltage was found as 32.3 V. As for optical characterization, gain, dark count rate, and photon detection efficiency have been measured as a function of bias voltage at room temperature. In particular, we show that the device had a comparable gain of ∼ 106 with respect to conventional PMTs and had a peak sensitivity in blue light regime. Furthermore, we attempt to explain possible causes of some of phenomena seen from the device characterization.

Defective Schwann cell lipid metabolism alters plasma membrane dynamics in Charcot-Marie-Tooth disease 1A

“…Once interacting with axons, SCPs can differentiate into immature Schwann cells, which organize axons to be myelinated and non-myelinated in a process defined as radial sorting (Mirsky et al, 2002). To understand how these CMT1A lipid alterations may originate at a cellular level, we developed a protocol to derive a Schwann cell lineage from iPSCs, which was a modified version of Kim et al (Kim et al, 2017). These differentiated iPSC-SCs had Schwann cell biand tripolar morphology, expressed Schwann cell genes, and could myelinate in vitro.…”

“…To model CMT1A in vitro, we used a protocol modified from Kim et al (Kim et al, 2017) to generate iPSC-derived Schwann cells (iPSC-SCs) and iPSC-SCPs (Fig. 3a).…”

“…The protocol to generate iPSC-SCPs was adapted from Kim et al (Kim et al, 2017). Briefly, iPSCs were split into small colonies or single cell state and seeded on Matrigel-GFR in E8 flex medium 24 h before initiation of the protocol.…”