Development of paper-based sensor coupled with smartphone detector for simple creatinine determination

Tambaru, David; Rupilu, Reski Helena; Nitti, Fidelis; Gauru, Imanuel; Suwari,

doi:10.1063/1.4978168

Cited by 10 publications

(5 citation statements)

References 16 publications

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“…In the literature there are some works with paper‐based devices devoted to the creatinine detection by colorimetric identification or electrochemical sensors based on enzymatic reactions and non‐enzymatic reactions . The colorimetric detections are dependent of visual acuity of the analyst, which is associated to operational error and may contribute to the increase of the uncertainty in measures.…”

Section: Resultsmentioning

confidence: 99%

New Disposable Electrochemical Paper‐based Microfluidic Device with Multiplexed Electrodes for Biomarkers Determination in Urine Sample

et al. 2020

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A disposable electrochemical paper‐based analytical device was constructed based on use of sequential analysis with multiplexed working electrodes and applied for the determination of glucose, creatinine, and uric acid. The device was constructed with 16 microfluidic channels, with 16 working electrodes arranged in four set with four components surrounding the sample injection hole. In addition, a commercial multiplexing module was used, which allowed for multiplexing of the 16 working electrodes. This design allowed for radial and homogeneous sample elution to each sensing spot for high throughput analysis. In the multiplexed determinations, distinct electrochemical procedures were employed for each analyte. Furthermore, each working electrode spot was modified to increase the respective analytical signals. For glucose detection, the sensor was based on electron mediation by ferrocenecarboxylic acid over the modified surface with glucose oxidase. The principle for creatinine detection was based on electrochemical reduction of non‐complexed Fe3+ in excess after complex formation between Fe3+ and creatinine in the chemical step. The anodic peak current responses for uric acid detection increased due to working electrode surface modification with carbon black nanoparticles. In the multiplexed analysis, the device provided limits of detection of 0.120 mmol L−1, 0.084 mmol L−1, and 0.012 mmol L−1 for glucose, creatinine, and uric acid, respectively. The developed device was successfully applied in the analyses of real urine samples.

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Section: Resultsmentioning

confidence: 99%

New Disposable Electrochemical Paper‐based Microfluidic Device with Multiplexed Electrodes for Biomarkers Determination in Urine Sample

et al. 2020

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“…Traditional methods of creatinine analysis are expensive, time-consuming, and impractical. By using low-cost paper, and coupling it with widely available smartphone apps, Tambaru et al developed a creatinine detector using an inexpensive and instrument-free method …”

Section: Functionalized Paper-based Point-of-care Devicesmentioning

confidence: 99%

“…By using low-cost paper, and coupling it with widely available smartphone apps, Tambaru et al developed a creatinine detector using an inexpensive and instrument-free method. 152 5.3. Expanding POC Devices for Blood Cell Diagnostics and Infectious Diseases.…”

Section: Poc Devices Formentioning

confidence: 99%

Paper as a Substrate and an Active Material in Paper Electronics

Khan

Nassar

Hussain

2020

ACS Appl. Electron. Mater.

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Paper is an essential part of our daily life in many different ways. It is made by compressing cellulose fibers sourced from wood into thin sheets. Paper is an inherently flexible material which can transport liquids through its medium by capillary action without the need of external force. The mesh network of cellulose in paper gives it a unique set of mechanical properties. Owing to its exclusive and advantageous properties, paper is being used as an active material and a substrate in electronics. Paper as an active material means that paper is utilized in its intrinsic form without modifications. Activated (or functionalized) paper has been widely exploited in many applications, but in order to take true advantage of all the beneficial properties of paper, it needs to be used in its natural produced form. Notably, paper is employed in humidity sensors, pressure sensors, and MEMS devices in its natural form. Additionally, paper is used as a substrate in additively manufactured and origami-inspired electronic devices. Here, we present an overview of how paper is used to make fully flexible and low-cost devices. Furthermore, the emergence of paper-based point-of-care devices is briefly discussed.

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“…Since the first report by the Whitesides group from Harvard University [16], there has been a vast development of μ-PADs as analytical tools for applications in food safety [17], health care [18][19] and environmental science [20][21], with some μ-PADs particularly devoted to the detection of Mn(II) in water samples [22][23][24]. Meredith et al [22] reported the development of paper-based microfluidics for the selective determination of Mn(II) in the presence of other cations using 4-(2-pyridylazo)resorcinol (PAR) as the non-specific colorimetric ligand.…”

Section: ■ Introductionmentioning

confidence: 99%

Simple Microfluidic Paper-Based Analytical Device (μ-PAD) Coupled with Smartphone for Mn(II) Detection Using Tannin as a Green Reagent

Nitti,

Ati,

De Rozari

et al. 2023

Indones. J. Chem.

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The development of a simple yet greener microfluidic paper-based analytical device (μ-PAD) for on-site detection of Mn(II) in various types of waters using tannin as a natural reagent was described. The μ-PAD consists of twelve detection zones, created on a Whatman Number 1 filter paper by a simple drawing technique using an acrylic watercolor. The detection of Mn(II) was based on the color change on the reaction zone due to the reaction between Mn(II) and the pre-deposited tannin. The μ-PAD image was captured by a portable smartphone detector, and the blue intensity was digitized using a color picker application to generate the reflectance as the analytical response. The proposed method was characterized by a linear dynamic range of 0.05–0.25 mg L−1 with the limit of detection (LOD) for the determination of Mn(II) of 0.026 mg L−1. The other analytical merits of the proposed method, such as precision (RSD, 1.107%), accuracy (E, 6.697%), and recovery (104–112%), were all comparable to the existing spectrophotometric methods. The method’s successful application to natural water samples from manganese mining sites aligns with the reference spectrophotometric method, indicating its good selectivity and accuracy without significant influence of commonly associated interfering ions.

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Development of paper-based sensor coupled with smartphone detector for simple creatinine determination

Cited by 10 publications

References 16 publications

New Disposable Electrochemical Paper‐based Microfluidic Device with Multiplexed Electrodes for Biomarkers Determination in Urine Sample

New Disposable Electrochemical Paper‐based Microfluidic Device with Multiplexed Electrodes for Biomarkers Determination in Urine Sample

Paper as a Substrate and an Active Material in Paper Electronics

Simple Microfluidic Paper-Based Analytical Device (μ-PAD) Coupled with Smartphone for Mn(II) Detection Using Tannin as a Green Reagent

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