Development of pediatric orally disintegrating mini-tablets containing atomoxetine hydrochloride-β-cyclodextrin inclusion complex using experimental design

Özyilmaz, Emine Dilek; Çomoğlu, Tansel

doi:10.1080/03639045.2022.2154787

Cited by 7 publications

(6 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absence of any melting peak of FB in the DSC thermograms of the inclusion complexes confirmed the formation of inclusion complexes and solid dispersion. [8]. As a result of the examination, it was determined that despite the crystal structure of FB and the void structure of β-CD, the inclusion complexes showed a cubic structure.…”

Section: Discussionmentioning

confidence: 96%

“…With this method, three different combinations of complexes were manufactured by preparing mixtures of 1 : 1 , 1 : 2 , 1 : 3 FB β-CD molar ratios, with mixing duration at 20 min. Ethanol:distilled water (1:1) was used as the solvent [8].…”

Section: Preparation Of Beta-cyclodextrin Inclusion Complex (β-Cd)mentioning

confidence: 99%

“…DSC thermograms were examined to confirm the inclusion complex formation of FB with β-CD and the formation of solid dispersions with PVP. The amount of amorphous and crystalline phases of the prepared complexes and dispersions were evaluated using Shimadzu DSC 60 (Japan) [8,9].…”

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

“…Stability studies of the two ODT formulations were performed in accordance with ICH guidelines. The appearance, hardness properties and FB amounts of ODTs were determined [8,15].…”

Section: Stability Studiesmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of two different orally disintegrating tablet formulations containing flurbiprofen inclusion complex and its solid dispersion

Özyılmaz¹,

Çomoğlu²

2023

Trop. J. Pharm Res

View full text Add to dashboard Cite

Purpose: To prepare orally dispersible tablet formulations (ODTs) by increasing the solubility of flurbiprofen (FB), which has low water solubility. Methods: The ODTs were prepared using direct compression method the inclusion complexes and solid dispersions with the highest solubility were further evaluated. Flurbiprofen, polyvinylpyrrolidone (PVP) solid dispersions were blended together by solvent evaporation method, while the inclusion complexes were co-formulated with beta cyclodextrin (β-CD) by kneading at three different ratios. The ODTs were characterized by differential scanning calorimetry (DSC), Fourier transform infra-red spectroscopy (FTIR) and for their micromeritic properties. In addition, the solubility properties of the inclusion complexes and solid dispersions in distilled water were compared with the solubility of flurbiprofen. Results: The highest solubility value of PVP-FB solid dispersions was found at 1:6 (0.501 mg/mL) and for FB β-CD inclusion complex at 1:2 (0.701 mg/mL). Angle of repose ranged from 28.09 – 32.15 (o); Carr’s index from 7.59 to 10.01; and Hausner’s ration from 1.05 – 1.15. DSC and spectral studies indicate that FB did not chemically interact with either PVP or β-CD. Conclusion: Orally dispersible tablets containing flurbiprofen β-CD complex exhibit significantly higher bioavailability than the drug alone due to its increased solubility.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Preparation Of Beta-cyclodextrin Inclusion Complex (β-Cd)mentioning

confidence: 99%

Section: Differential Scanning Calorimetry (Dsc)mentioning

confidence: 99%

“…Stability studies of the two ODT formulations were performed in accordance with ICH guidelines. The appearance, hardness properties and FB amounts of ODTs were determined [8,15].…”

Section: Stability Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of two different orally disintegrating tablet formulations containing flurbiprofen inclusion complex and its solid dispersion

Özyılmaz¹,

Çomoğlu²

2023

Trop. J. Pharm Res

View full text Add to dashboard Cite

show abstract

“…These attributes include hardness, friability, taste acceptability, disintegration time, and dissolution rate. By adopting this approach, we have found that time and cost savings can be achieved in the formulation development process (Tashan et al, 2020;Özyılmaz and Comoglu, 2022).…”

Section: Introductionmentioning

confidence: 99%

Development and in vivo evaluation of atomoxetine hydrochloride ODMTs in a nicotine-induced attention deficit hyperactivity disorder (ADHD) model in rats

ATALAY,

OZYILMAZ,

ONAL

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

The study aimed to evaluate in vitro and in vivo oral rapid mini tablets containing atomoxetine hydrochloride (ATO), developed for children with Attention Deficit and Hyperactivity (ADHD). An inclusion complex of ATO with β-cyclodextrin (β-CD) was prepared to mask the bitter taste of ATO and make it suitable for oral administration to children. ODMTs were administered to ADHD mice born from nicotine-administered mother mice during pregnancy and lactation, allowing the assessment of their efficacy in vivo setting. Results obtained from the open field test, new object recognition test, and Barnes maze test revealed that the ODMT formulation containing ATO-β-CD inclusion complexes exhibited potential as an alternative to the capsule form of ATO. As a conclusion, factorial experimental design was employed in the preparation of ATO-β-CD complexes and ODMTs, and the experimental animals were subjected to hyperactivity induced by nicotine, thereby providing a distinct context in which the developed ODMT formulation was evaluated.

show abstract

Evaluation of the effect of carvedilol orodispersible tablets on ischemia–reperfusion injury and flap viability in rats: An in vivo study

Tokgonul,

Ozyilmaz,

Comoglu

et al. 2024

Archiv der Pharmazie

View full text Add to dashboard Cite

Flap surgery is an integral part of plastic surgery, and ischemia–reperfusion (I/R) injury significantly affects the viability of the flap. Carvedilol (CRV), a nonselective beta‐blocker with alpha‐1 blocking and antioxidant properties, and known for its potential in reducing I/R damage, was chosen as the active substance for our study. The aim of this study was to investigate the vasodilator and antioxidant effects of CRV on rat inferior epigastric artery skin flap using orally disintegrating tablets (ODTs). The optimized ODT formulation was subjected to in vivo experiments using Sprague–Dawley female rats (n = 24) divided into three groups: Group I (control, I/R), Group II (treatment, I/R + CRV), and Group III (treatment, I/R), I/R + CRV ODT). Reperfusion was then observed following the release of the microclamp from the pedicle, and the flap was then re‐adapted to its original position. Control rats were given oral isotonic solution via gavage and were subjected to 8 h of ischemia and 12 h of reperfusion. Group II was given 2 mg/kg CRV oral tablets for 7 days before and after surgery. Group III was given 2 mg/kg/day CRV ODT for the same period. Biopsies were taken from the flap and histopathological and biochemical analyses including superoxide dismutase, glutathionenitric oxide, malondialdehyde, paraoxonase 1, total oxidant, and total antioxidant capacities were performed. This study demonstrates that CRV ODTs significantly increased flap viability by approximately 25% compared to the control group, highlighting their promising therapeutic potential.

show abstract

Development of pediatric orally disintegrating mini-tablets containing atomoxetine hydrochloride-β-cyclodextrin inclusion complex using experimental design

Cited by 7 publications

References 38 publications

Evaluation of two different orally disintegrating tablet formulations containing flurbiprofen inclusion complex and its solid dispersion

Evaluation of two different orally disintegrating tablet formulations containing flurbiprofen inclusion complex and its solid dispersion

Development and in vivo evaluation of atomoxetine hydrochloride ODMTs in a nicotine-induced attention deficit hyperactivity disorder (ADHD) model in rats

Evaluation of the effect of carvedilol orodispersible tablets on ischemia–reperfusion injury and flap viability in rats: An in vivo study

Contact Info

Product

Resources

About