Development of Pericardial Mesothelioma in Golden Retrievers with a Long-term History of Idiopathic Haemorrhagic Pericardial Effusion

Motomura, Noboru; Tanaka, Ryou; Takemura, Naoyuki; Fujii, Yûzo; Ueno, Akihisa; Mitsumori, Kunitoshi

doi:10.1016/j.jcpa.2004.03.002

Cited by 43 publications

(34 citation statements)

References 13 publications

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“…Although most studies described that canine mesotheliomas have been seen with both pleural and pericardial effusion [2,4,5,7,8], in our case we did not determine any evidence of pericardial effusion and even effusion in abdominal cavity.…”

Section: Discussioncontrasting

confidence: 86%

Pleural Effusion in a Dog with Mesothelioma

Ülgen¹,

Bakırel²,

KutayYıldız³

et al. 2015

JLS

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In this case; mesothelioma was likely diagnosed in 7 years old male mix breed dog which was brought to Veterinary Research and Teaching Hospital of Istanbul University with complaints of general weakness and severe dyspnea. The dog had been misdiagnosed with faryngitis and hernia diaphragmatica before it was brought to our faculty clinic. Apparent abdominal respiration was inspected and supressed heart sounds, abnormal respiratory sounds and pleural rub were detected by auscultation of thorax. Radiographic examination and blood analysis were performed. Chest X-ray examination demonstrates both sided pleural effusion. Leukocytosis (WBC = 36.2  10 3 µL) was detected on blood count. By thoracocentesis, 40 mL fluid was drained and cytologic examination was performed. Numerous pleomorphic, atypical, multinuclear or multinucleolar mesothelial cells were observed and cytologic findings were pretty compatible with mesothelioma. The dog died before medication and the owner of the dog didn't give the confirmation for necropsy. In our clinical case we did not confirm any contact of the dog with asbestos or larger amount of pesticides, which are described as etiological factors of mesothelioma. As mesothelioma is a very rare health condition for dogs, it might be lead up to misdiagnosis.

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Section: Discussioncontrasting

confidence: 86%

Pleural Effusion in a Dog with Mesothelioma

Ülgen¹,

Bakırel²,

KutayYıldız³

et al. 2015

JLS

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show abstract

“…The role of chronic inflammation in favoring the growth of MM appears supported by the increased risk of peritoneal MM in patients with familial Mediterranean fever (Bani-Hani and Gharaibeh 2005; Herschovici et al 2006, Ishak et al 2006), a condition characterized by recurrent polyserositis that mainly involves the peritoneum and the observation that MM may follow pneumothorax and/or trauma (Gorovenko GG, Slepukha IM, et al 1986; Hillerdal and Berg 1972). MM has also been reported in dogs with idiopathic hemorrhagic effusions that develop chronic reactive inflammation (Machida et al, 2004). Presently, we are using animal models to test chemo-preventive strategies such as inhibiting HMGB-1 and the inflammatory response associated with HMGB-1 release to prevent MM in high-risk individuals.…”

Section: Mechanisms Of Asbestos Pathogenesismentioning

confidence: 94%

Malignant mesothelioma: Facts, Myths, and Hypotheses

Carbone

Dodson³

et al. 2011

Journal Cellular Physiology

326

380

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Malignant mesothelioma (MM) is a neoplasm arising from mesothelial cells lining the pleural, peritoneal, and pericardial cavities. Over 20 million people in the US are at risk of developing MM due to asbestos exposure. MM mortality rates are estimated to increase by 5-10% per year in most industrialized countries until about 2020. The incidence of MM in men has continued to rise during the past 50 years, while the incidence in women appears largely unchanged. It is estimated that about 50-80% of pleural MM in men and 20-30% in women developed in individuals whose history indicates asbestos exposure(s) above that expected from most background settings. While rare for women, about 30% of peritoneal mesothelioma in men has been associated with exposure to asbestos. Erionite is a potent carcinogenic mineral fiber capable of causing both pleural and peritoneal MM. Since erionite is considerably less widespread than asbestos, the number of MM cases associated with erionite exposure is smaller. Asbestos induces DNA alterations mostly by inducing mesothelial cells and reactive macrophages to secrete mutagenic oxygen and nitrogen species. In addition, asbestos carcinogenesis is linked to the chronic inflammatory process caused by the deposition of a sufficient number of asbestos fibers and the consequent release of pro-inflammatory molecules, especially HMGB-1, the master switch that starts the inflammatory process, and TNF-alpha by macrophages and mesothelial cells. Genetic predisposition, radiation exposure and viral infection are co-factors that can alone or together with asbestos and erionite cause MM.

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“…A clue comes also from animal pathology. Pericardial mesotheliomas have been observed among dogs (golden retrievers), affected by recurrent pericardial effusion 85) .…”

Section: Co-factorsmentioning

confidence: 99%

Malignant Mesothelioma: Global Incidence and Relationship with Asbestos

2007

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Mesothelioma incidence varies markedly from one country to another. The highest annual crude incidence rates (about 30 cases per million) are observed in Australia, Belgium, and Great Britain. A lot of data indicate a relationship between mesothelioma and asbestos. The hot areas for mesothelioma exactly correspond to the sites of industries with high asbestos use, such as shipbuilding and asbestos-cement industry. However, in many countries with high asbestos consumption, mesothelioma incidence is low. The reasons for this fact are not clear. The latency periods elapsing between first exposure to asbestos and development of mesothelioma are mostly longer than 40 yr. An inverse relationship exists between intensity of asbestos exposure and length of the latency period. Mesothelioma generally develops after long-time exposures to asbestos. Some recent studies show that the risk increases with the duration of exposure. Possible co-factors in the pathogenesis of asbestos-related mesothelioma include genetic predisposition, diets poor in fruit and vegetables, viruses, immune impairment, recurrent serosal inflammation. The study of co-morbidity in mesothelioma could give an insight into the pathogenesis of the tumor. While a levelling-off in mesothelioma incidence has been registered in some countries, a worsening of the epidemic is predictable in large parts of the world.

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Development of Pericardial Mesothelioma in Golden Retrievers with a Long-term History of Idiopathic Haemorrhagic Pericardial Effusion

Cited by 43 publications

References 13 publications

Pleural Effusion in a Dog with Mesothelioma

Pleural Effusion in a Dog with Mesothelioma

Malignant mesothelioma: Facts, Myths, and Hypotheses

Malignant Mesothelioma: Global Incidence and Relationship with Asbestos

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