Development of Peyronie’s and Dupuytren’s diseases in an individual after single episodes of trauma: A case report and review of the literature

Connelly, Thomas J.

doi:10.1016/s0190-9622(99)70415-9

Cited by 14 publications

(10 citation statements)

References 25 publications

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“…This data, combined with previous finding, further support that the precursor cells of palmar fibromatosis originated from FSCs but not from BMSCs. Because trauma or surgery can cause increased TGF-β1 [ 16 , 17 ], risk of recurrence of fibromatosis following these events is high. In our previous study, among fibrosis-related growth factors, such as basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) and TGF-β1, exogenous TGF-β1 significantly enhanced myofibroblastic differentiation of FSCs but not BMSCs [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Corticosteroid inhibits differentiation of palmar fibromatosis-derived stem cells (FSCs) through downregulation of transforming growth factor-β1 (TGF-β1)

Wang¹,

Chiang³

et al. 2018

PLoS ONE

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Treatment for musculoskeletal fibromatosis remains challenging. Surgical excision for fibromatosis is the standard therapy but recurrence remains high. Corticosteroids, an anti-fibrogenic compound, have been used to treat early stage palmar fibromatosis, but the mechanism is unknown. We investigated the inhibitory mechanism effect of corticosteroids in the murine model of fibromatosis nodule as well as in cultured FSCs. Quantitative reverse transcription/polymerase chain reaction (PCR) analysis and immunofluorescence (IF) staining for markers of myofibroblasts (α-smooth muscle actin and type III collagen) were used to examine the effect of dexamethasone on myofibroblasic differentiation of FSCs both in vitro and in vivo. Transforming growth factor-β1 (TGF-β1) signaling and its downstream targets were examined using western blot analysis. TGF-β1 expression in FSCs before and after dexamethasone treatment was compared. In addition, inhibition of TGF-β1 expression was examined using RNA interference (RNAi) on FSCs, both in vitro and in vivo. Treating FSCs with dexamethasone inhibited FSCs’ myofibroblastic differentiation in vitro. Treating FSCs with dexamethasone before or after implantation further inhibited formation of fibromatosis nodules. Dexamethasone suppressed expression of TGF-β1 and pSmad2/3 by FSCs in vitro. TGF-β1 knockdown FSCs showed reducing myofibroblastic differentiation both in vitro and in vivo. Finally, addition of TGF-β1 abolished dexamethasone-mediated inhibition of myofibroblastic differentiation. Dexamethasone inhibits the myofibroblastic differentiated potential of FSCs both in vitro and in vivo through inhibition of TGF-β1 expression in FSCs. TGF-β1 plays a key role in myofibroblastic differentiation.

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Section: Discussionmentioning

confidence: 99%

Corticosteroid inhibits differentiation of palmar fibromatosis-derived stem cells (FSCs) through downregulation of transforming growth factor-β1 (TGF-β1)

Wang¹,

Chiang³

et al. 2018

PLoS ONE

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“…A higher level of TGF-β1 has been found in palmar fibromatosis [42] and penile fibromatosis [43] compared with normal tissues. Because TGF-β1 is released after local trauma or after surgical excision [44], the prevalence or recurrence of fibromatosis is associated with previous trauma [45] and surgery history [2]; [13]–[15]. However, the detailed mechanism by which the increase in endogenous TGF-β1 production is involved in the development of fibromatosis requires further investigation.…”

Section: Discussionmentioning

confidence: 99%

Recapitulation of Fibromatosis Nodule by Multipotential Stem Cells in Immunodeficient Mice

et al. 2011

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Musculoskeletal fibromatosis remains a disease of unknown etiology. Surgical excision is the standard of care, but the recurrence rate remains high. Superficial fibromatosis typically presents as subcutaneous nodules caused by rapid myofibroblast proliferation followed by slow involution to dense acellular fibrosis. In this study, we demonstrate that fibromatosis stem cells (FSCs) can be isolated from palmar nodules but not from cord or normal palm tissues. We found that FSCs express surface markers such as CD29, CD44, CD73, CD90, CD105, and CD166 but do not express CD34, CD45, or CD133. We also found that FSCs are capable of expanding up to 20 passages, that these cells include myofibroblasts, osteoblasts, adipocytes, chondrocytes, hepatocytes, and neural cells, and that these cells possess multipotentiality to develop into the three germ layer cells. When implanted beneath the dorsal skin of nude mice, FSCs recapitulated human fibromatosis nodules. Two weeks after implantation, the cells expressed immunodiagnostic markers for myofibroblasts such as α-smooth muscle actin and type III collagen. Two months after implantation, there were fewer myofibroblasts and type I collagen became evident. Treatment with the antifibrogenic compound Trichostatin A (TSA) inhibited the proliferation and differentiation of FSCs in vitro. Treatment with TSA before or after implantation blocked formation of fibromatosis nodules. These results suggest that FSCs are the cellular origin of fibromatosis and that these cells may provide a promising model for developing new therapeutic interventions.

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“…La prevalencia es superior en quienes han sufrido traumatismos claros en la mano [23,24], incluso independientemente de su trabajo manual [22]. Padecerán una contractura palmar de Dupuytren, siempre en un grado leve, cerca del 11 % de los afectados por una fractura de Colles desplazada [13] y se han publicado casos desencadenados por quemaduras en la extremidad superior [25], por incisiones quirúrgicas en la mano [26] y por un traumatismo deportivo [27].…”

Section: Discussionunclassified

Avulsión de parte de una falange, síndrome del túnel carpiano y contractura de Dupuytren: ¿Coincidencia o relación causal?

Pérez¹

2005

Cuad. med. forense

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RESUMENEn la mayoría de los casos, el origen del síndrome del túnel carpiano (STC) y el de la contractura de Dupuytren son desconocidos, sin embargo aquí presentamos la asociación de ambos padecimientos en la mano de una enferma que pocos meses antes había sufrido la avulsión de parte de una falange en ella. Al comparar los hechos con los datos de la bibliografía científica, concluimos que la avulsión fue la causa del STC o bien su desencadenante directo en una mujer que tendría alguna predisposición anatómica a padecerlo. La conclusión es aún más clara para la contractura de Dupuytren en estadio inicial en esta lesionada. Ambas enfermedades aparecieron después del traumatismo, su relación causal es coherente con los conocimientos científicos, se han publicado ya casos similares y esta mujer carecía de la mayoría de los factores de riesgo descritos en la bibliografía tanto para el STC como para la contractura palmar idiopáticos.Palabras clave: Contractura de Dupuytren, etiología, postraumático, síndrome del túnel carpiano, traumatología. Cuad Med Forense 2005; 11(40):107-111 ABSTRACTIn most cases, the etiology of carpal tunnel syndrome (CTS) and of Dupuytren's contracture are unknown. However, here both diseases are presented associated in the hand of a woman that several months before had suffered the avulsion of part of a phalanx. Comparing these facts with the data from the literature, the conclusion is that the avulsion has been either the cause of the CTS or its direct trigger in a woman that probably had some anatomical predisposition for the disease; this conclusion is even clearer for the initial stage of Dupuytren's contracture in this woman, because both appeared after the trauma, its causal relationship is coherent with the scientific knowledge, given that similar situations have been described, and because the woman lacked most of the risk factors associated in the literature with the idiopathic CTS or with the idiopathic Dupuytren's contracture.

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Development of Peyronie’s and Dupuytren’s diseases in an individual after single episodes of trauma: A case report and review of the literature

Cited by 14 publications

References 25 publications

Corticosteroid inhibits differentiation of palmar fibromatosis-derived stem cells (FSCs) through downregulation of transforming growth factor-β1 (TGF-β1)

Corticosteroid inhibits differentiation of palmar fibromatosis-derived stem cells (FSCs) through downregulation of transforming growth factor-β1 (TGF-β1)

Recapitulation of Fibromatosis Nodule by Multipotential Stem Cells in Immunodeficient Mice

Avulsión de parte de una falange, síndrome del túnel carpiano y contractura de Dupuytren: ¿Coincidencia o relación causal?

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