2020
DOI: 10.1002/jat.3935
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Development of photo‐amino acid derivative reactivity assay: a novel in chemico alternative method for predicting photoallergy

Abstract: Photoallergy test of cosmetics and several types of pharmaceutical substances is often necessary for obtaining approval from authorities. However, there are no official test guidelines for photoallergy evaluation. Therefore, we tried to establish a photoallergy test by utilizing an in chemico alternative sensitization method, amino acid derivative reactivity assay (ADRA). To determine the criteria for judging the photoallergy potential, photo-ADRA with or without photoirradiation was performed using 60 photoal… Show more

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Cited by 8 publications
(3 citation statements)
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References 26 publications
(28 reference statements)
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“…These studies can be useful for understanding certain aspects of photobinding steps that will help researchers to design future potential in silico models, but do not provide real progress in the field of photosafety assessment. The other four adapt ADRA [44,45] or DPRA [42,44,46] assays to identify contact sensitizers by coupling UVA lamps. The assays proved to be transferable among laboratories experienced in conducting high-performance liquid chromatography analysis [61].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…These studies can be useful for understanding certain aspects of photobinding steps that will help researchers to design future potential in silico models, but do not provide real progress in the field of photosafety assessment. The other four adapt ADRA [44,45] or DPRA [42,44,46] assays to identify contact sensitizers by coupling UVA lamps. The assays proved to be transferable among laboratories experienced in conducting high-performance liquid chromatography analysis [61].…”
Section: Discussionmentioning
confidence: 99%
“…3.2.12. Yamamoto et al, 2020 [45] In this study, the authors performed a more detailed analysis of the predictive capacity of the photo-ADRA assay. The information of the photoallergenic activity of the different chemicals has been obtained from in vivo animal experiments and from patch test studies in volunteers [64].…”
Section: Patel Et Al 2019 [44]mentioning
confidence: 99%
“…Hence, it is clear that when measuring the reaction solution, almost the same result could be obtained irrespective of using HPLC-UV or HPLC-FL, indicating that any detection method can be used in ADRA (4 mM). ADRA is an alternative method that can be applied to difficult-totest substances such as multicomponent mixtures with unknown molecular weights and to test chemicals other than skin sensitizers such as photoallergic substances (Yamamoto et al, 2019a;Fujita et al, 2019b;Wanibuchi et al, 2019;Yamamoto et al, 2020). We believe that further expansion of the application range of ADRA and its application to other test methods will provide a greater utility value and higher benefit to the public.…”
Section: Discussionmentioning
confidence: 99%