Development of photo-magnetic drug delivery system by facile-designed dual stimuli-responsive modified biopolymeric chitosan capped nano-vesicle to improve efficiency in the anesthetic effect and its biological investigations

Liu, Hongwei; Liu, Junfeng; Xie, Xian-Feng; Li, Xuebin

doi:10.1016/j.jphotobiol.2019.111716

Cited by 27 publications

(12 citation statements)

References 36 publications

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“…They are organometallic precursors for silica, aluminium, titanium, zirconium and many others, and alcohols are the mutual solvents used in this technique. At least one or more of the chosen alkoxides should be included in the sol-gel technique to obtain homogeneous nanomaterials [ 68 , 69 , 70 , 71 , 72 ]. In practice, the chemical precipitation technique shows greater superiority if compared with the sol-gel technique as it requires low-cost starting materials and facile and simple preparation steps, along with easy scale-up manufacturing techniques.…”

Section: Production Methods Of Nanomaterialsmentioning

confidence: 99%

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

et al. 2021

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Designing of nanomaterials has now become a top-priority research goal with a view to developing specific applications in the biomedical fields. In fact, the recent trends in the literature show that there is a lack of in-depth reviews that specifically highlight the current knowledge based on the design and production of nanomaterials. Considerations of size, shape, surface charge and microstructures are important factors in this regard as they affect the performance of nanoparticles (NPs). These parameters are also found to be dependent on their synthesis methods. The characterisation techniques that have been used for the investigation of these nanomaterials are relatively different in their concepts, sample preparation methods and obtained results. Consequently, this review article aims to carry out an in-depth discussion on the recent trends on nanomaterials for biomedical engineering, with a particular emphasis on the choices of the nanomaterials, preparation methods/instruments and characterisations techniques used for designing of nanomaterials. Key applications of these nanomaterials, such as tissue regeneration, medication delivery and wound healing, are also discussed briefly. Covering this knowledge gap will result in a better understanding of the role of nanomaterial design and subsequent larger-scale applications in terms of both its potential and difficulties.

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Section: Production Methods Of Nanomaterialsmentioning

confidence: 99%

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

et al. 2021

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“…The drug release was stimulated by alternating magnetic fields [ 185 ]. In a different study, ZnFe 2 O 4 nanoparticles were coated with chitosan to cargo lidocaine, a local anesthetic [ 186 ]. A novel copolymeric system of poly[(2-succinyloxyethylmethacrylate)-b-(N-isopropylacrylamide)-b dimethyl aminoethylmetha- crylate) was fabricated by RAFT polymerization.…”

Section: Stimuli-responsive Polymeric Nanocarriers For Drug and Gmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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“…pH and temperature-responsive NPs: Liu et al [152] developed a dual (pH and temperature) responsive bio-nanomaterial to improve the efficiency of an anesthetic drug delivery system. The surface engineering of ZnFe 2 O 4 NPs was performed by coating with chitosan using a simple precipitation method.…”

Section: Stimuli Responsive Chitosan Chitosan Nanoparticles and Nanocompositesmentioning

confidence: 99%

“…External stimuli NPs: External stimuli such as light [133], ultrasound [157], heat [39], and magnetic/electrical fields [152] affect the conformation or configuration of CS in the diseased tissue. These stimuli can be applied to improve cargo release into the diseased area to treat cancer, heart attack, and neurodegenerative diseases including Alzheimer's and Parkinson's.…”

Section: Stimuli Responsive Chitosan Chitosan Nanoparticles and Nanocompositesmentioning

confidence: 99%

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

299

120

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Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

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Development of photo-magnetic drug delivery system by facile-designed dual stimuli-responsive modified biopolymeric chitosan capped nano-vesicle to improve efficiency in the anesthetic effect and its biological investigations

Cited by 27 publications

References 36 publications

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

Nanomaterials for Biomedical Applications: Production, Characterisations, Recent Trends and Difficulties

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Advances in Chitosan-Based Nanoparticles for Drug Delivery

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