In this paper, we present a comprehensive assessment of the effects of residential loads, electric vehicles (EVs), and electric heat pumps (HPs) on low-voltage (LV) grids in urban, suburban, and rural areas of Germany. Firstly, real data are used to determine the typical structures for each LV grid region. Secondly, nine scenarios are defined with different levels of EV and HP penetration. Thirdly, the Low Voltage Load Flow Calculation in the DIgSILENT PowerFactory is performed for all scenarios while taking the simultaneity factor (SF) for each load type into consideration to calculate the minimum voltage and maximum loadings of transformer and lines in each grid; this allows for the grid’s potential bottlenecks to be identified. The network simulations are carried out with the consideration of charging powers of 11 kW and 22 kW in order to evaluate how an increasing EV load in the future may affect the grid’s parameters. To the best of our knowledge, no study in the literature has simultaneously addressed all of the aforementioned topics. The results of this study provide a useful framework that distribution system operators (DSOs) may apply to anticipate the forthcoming challenges and figure out when grid reinforcement will be required.