Development of plant based bioactive, anticoagulant and antioxidant surface coatings for medical implants

Bioinspired chitosan based functionalization of biomedical implant surfaces for enhanced hemocompatibility, antioxidation and anticoagulation potential: an in silico and in vitro study

“…For the 3D visualization of macromolecules, PyMole and 2D ligand-protein interaction LigPlot ++ was employed. 9 In addition, ligand conformation and orientation in its inhibited-protein active site was visualized on 2D planes. [69][70][71]…”

“…7 There are also bioactive strategies which use pharmacologic active ingredients for the inhibition of the coagulation and immune response by local drug delivery or permanent immobilization of an active agent on the surface. 8,9 Thrombosis is one of the major issues which are responsible for the adverse effects of implants and their failure. The platelet activation and coagulation around the implant can block the blood ow and isolate the implant from the surrounding environment rendering it unable to perform its functions.…”

“…7 There are also bioactive strategies which use pharmacologic active ingredients for the inhibition of the coagulation and immune response by local drug delivery or permanent immobilization of an active agent on the surface. 8,9…”

“…Among natural anticoagulants includes A. sativum , 20 C. longa , 21 C. cassia , 22 A. sinensis , 23 P. ginseng 24 and O. tenuiflorium 25 which are well reported for their effectiveness and feasibility in biomedical applications. In our latest study, we reported the anticoagulation effects of individual and combined effects of C. cassia , O. tenuiflorium and P. ginseng for biomedical applications 9 and in this study, we focused on C. verum , A. sinensis and F. vulgare based drugs and tried to explore their suitability for biomedical implants applications.…”

In Vivo Biocompatibility Study on Functional Nanostructures Containing Bioactive Glass and Plant Extracts for Implantology

“…Thin films offer a range of benefits, including enhanced biocompatibility [7], improved osseointegration [8], reduced infection rates [9], and controlled drug release [10]. Most modern approaches in this field involve the use of films containing plant extracts for implant covering; this is an area of research that explores the potential benefits of incorporating natural compounds into thin-film coatings [11][12][13][14]. Plant extracts contain a wide range of bioactive compounds, such as polyphenols, flavonoids, terpenoids, and alkaloids, which have shown various beneficial properties, including antioxidant, antimicrobial, antiinflammatory, and osteogenic activities.…”