Development of poly (I:C) modified doxorubicin loaded magnetic dendrimer nanoparticles for targeted combination therapy

Khodadust, Rouhollah; Ünsoy, Gözde; Gündüz, Ufuk

doi:10.1016/j.biopha.2014.10.009

Cited by 24 publications

(26 citation statements)

References 43 publications

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“…As a free drug, DOX often exhibits cardiotoxic side effects 33. Khodadust et al 34 have shown that polyinosinic:polycytidylic acid (poly I:C)-modified G4 dendrimer-coated SPIO nanoparticles (PIC-G4DcMNP-DOX) could overcome this resistance and deliver DOX inside cancer cells to induce high cytotoxic effects. These authors performed a comparative study of DOX loading, release, and biocompatibility profiles on different generations of PAMAM dendrimer-coated SPIO structures, and found that G4 dendrimers were the most effective for both delivering DOX at a lower pH and overcoming the DOX resistance mechanism in breast cancer cells 35.…”

Section: Magnetic Resonance Cancer Theranosticsmentioning

confidence: 99%

“…So, a higher concentration of the modified nanovehicles could be administered without causing more damage to the healthy cells. However, this poly I:C is bound to the surface of the dendrimer by a phosphoramide bond, which is cleaved by the overexpressed phosphoramidase enzyme in the tumor cells, resulting in release of poly I:C and catalyzing the release of DOX to induce maximum toxicity inside the tumor cells 34. The DOX-integrated nanovehicle, PIC-G4DcMNP-DOX, showed a lower half maximal inhibitory concentration, indicating higher cytotoxicity compared to free drug 34.…”

Section: Magnetic Resonance Cancer Theranosticsmentioning

confidence: 99%

“…However, this poly I:C is bound to the surface of the dendrimer by a phosphoramide bond, which is cleaved by the overexpressed phosphoramidase enzyme in the tumor cells, resulting in release of poly I:C and catalyzing the release of DOX to induce maximum toxicity inside the tumor cells 34. The DOX-integrated nanovehicle, PIC-G4DcMNP-DOX, showed a lower half maximal inhibitory concentration, indicating higher cytotoxicity compared to free drug 34. The IC 50 for poly I:C was 7 µg mL -1 and the IC 50 for DOX was 12 µg mL -1 in this integrated complex PIC-G4DcMNP-DOX, whereas free DOX and free poly I:C showed IC 50 of 170 µg mL -1 and 450 µg mL -1 , respectively, when tested at 1 μM in DOX-resistant MCF-7 cells.…”

Section: Magnetic Resonance Cancer Theranosticsmentioning

confidence: 99%

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Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics

Ray¹,

Zhao²,

Hsu³

et al. 2018

Theranostics

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Cancer theranostics is one of the most important approaches for detecting and treating patients at an early stage. To develop such a technique, accurate detection, specific targeting, and controlled delivery are the key components. Various kinds of nanoparticles have been proposed and demonstrated as potential nanovehicles for cancer theranostics. Among them, polymer-like dendrimers and copolymer-based core-shell nanoparticles could potentially be the best possible choices. At present, magnetic resonance imaging (MRI) is widely used for clinical purposes and is generally considered the most convenient and noninvasive imaging modality. Superparamagnetic iron oxide (SPIO) and gadolinium (Gd)-based dendrimers are the major nanostructures that are currently being investigated as nanovehicles for cancer theranostics using MRI. These structures are capable of specific targeting of tumors as well as controlled drug or gene delivery to tumor sites using pH, temperature, or alternating magnetic field (AMF)-controlled mechanisms. Recently, Gd-based pseudo-porous polymer-dendrimer supramolecular nanoparticles have shown 4-fold higher T1 relaxivity along with highly efficient AMF-guided drug release properties. Core-shell copolymer-based nanovehicles are an equally attractive alternative for designing contrast agents and for delivering anti-cancer drugs. Various copolymer materials could be used as core and shell components to provide biostability, modifiable surface properties, and even adjustable imaging contrast enhancement. Recent advances and challenges in MRI cancer theranostics using dendrimer- and copolymer-based nanovehicles have been summarized in this review article, along with new unpublished research results from our laboratories.

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Section: Magnetic Resonance Cancer Theranosticsmentioning

confidence: 99%

Section: Magnetic Resonance Cancer Theranosticsmentioning

confidence: 99%

Section: Magnetic Resonance Cancer Theranosticsmentioning

confidence: 99%

See 1 more Smart Citation

Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics

Ray¹,

Zhao²,

Hsu³

et al. 2018

Theranostics

View full text Add to dashboard Cite

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“…It is also the development trend of future research. Khodadust et al (2014) produced different sized chitosan MNPs by in situ synthesis method. It showed that the chitosan MNPs had pH responsive release characteristics.…”

Section: Chitosans and Its Derivatives As Vehicles To Deliver Chemicamentioning

confidence: 99%

Chitosan and its derivatives as vehicles for drug delivery

2017

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Chitosan and its derivatives as vehicles for drug delivery can achieve the purpose of sustained release and controlled release for drugs, improve the stability of drugs, and reduce adverse drug reactions. So, the bioavailability of drugs can be enhanced. Therefore, chitosan and its derivatives have become a hotspot in the field of drug delivery. Their characteristics as drug delivery vectors were introduced, the types and applications were summarized. The development direction of chitosan and its derivatives in this field was also forecasted.

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“…Ideally, these issues could be overcome by simultaneously delivering multiple therapeutic agents using a nanocarrier system [22]. To date, various nanocarriers have been explored for combination chemotherapy, including liposomes, dendrimers, micelles, and nanoparticles (NPs) [23-25]. Of these, polymeric NPs have been the most widely used platform owing to their high stability, high drug encapsulation efficiency, controlled drug-release profiles, and availability of surface functional groups for ligand conjugation or coating [26].…”

Section: Introductionmentioning

confidence: 99%

Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy

et al. 2015

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Nanoparticle (NP)-based combination chemotherapy has been proposed as an effective strategy for achieving synergistic effects and targeted drug delivery for colon cancer therapy. Here, we fabricated a series of hyaluronic acid (HA)-functionalized camptothecin (CPT)/curcumin (CUR)-loaded polymeric NPs (HA-CPT/CUR-NPs) with various weight ratios of CPT to CUR (1:1, 2:1 and 4:1). The resultant spherical HA-CPT/CUR-NPs had a desirable particle size (around 289 nm), relative narrow size distribution, and slightly negative zeta potential. These NPs exhibited a simultaneous sustained release profile for both drugs throughout the time frame examined. Subsequent cellular uptake experiments demonstrated that the introduction of HA to the NP surface endowed NPs with colon cancer-targeting capability and markedly increased cellular uptake efficiency compared with chitosan-coated NPs. Importantly, the combined delivery of CPT and CUR in one HA-functionalized NP exerted strong synergistic effects. HA-CPT/CUR-NP (1:1) showed the highest antitumor activity among the three HA-CPT/CUR-NPs, resulting in an extremely low combination index. Collectively, our findings indicate that this HA-CPT/CUR-NP can be exploited as an efficient formulation for colon cancer-targeted combination chemotherapy.

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Development of poly (I:C) modified doxorubicin loaded magnetic dendrimer nanoparticles for targeted combination therapy

Cited by 24 publications

References 43 publications

Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics

Dendrimer- and copolymer-based nanoparticles for magnetic resonance cancer theranostics

Chitosan and its derivatives as vehicles for drug delivery

Hyaluronic acid-functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy

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