Development of Poly(vinyl alcohol) Based Systems for Wound Dressings

Staško, Jolanta; Kalniņš, Mārtiņš; Dzene, Anda; Tupureina, Velta

doi:10.1007/978-3-540-69367-3_22

IFMBE Proceedings

2008

DOI: 10.1007/978-3-540-69367-3_22

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Development of Poly(vinyl alcohol) Based Systems for Wound Dressings

Jolanta Staško¹,

Mārtiņš Kalniņš²,

Anda Dzene³

et al.

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2012

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“…Our previous works [9,10] show that the most favourable molecular weight of PVA, suitable for gel preparation by the freezing/thawing technique, is about 130 × 103 g/mol. Water solutions of PVA with a higher molecular weight (145 × 10 3 g/mol and more) are too viscose.…”

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confidence: 99%

Characterization of cryogenically slightly crosslinked biomedical poly(vinyl alcohol) gels

Staško¹,

Kalniņš²,

Bērziņa-Cimdiņa³

2012

Proc. Estonian Acad. Sci.

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Poly(vinyl alcohol) gels, prepared by the freezing/thawing technique, were studied. Poly(vinyl alcohol) water solutions were exposed to 1-3 subsequent cycles of freezing (12 h at -20 °C) followed by thawing (12 h at 20 °C). Water content (weight and volume fraction) and degree of swelling α at the equilibrium state were determined. Average molecular weights of polymer chains between crosslinks M C (using the Flory-Rehner approach) were calculated. Values of α and M C considerably decrease with the growth of the number of freezing/thawing cycles n C .The modulus of elasticity E, tensile strength σ B , and elongation at brake ε B were determined from experimental stress-strain relationships of swollen gels. The E and σ B and values considerably increase with n C : up to 6-8 times for E and almost by an order for tensile strength σ B . More concentrated water solutions provide almost two times greater E and σ B values. Strengthdeformation characteristics for gels prepared at n C = 2-3 are acceptable for their application in potential drug delivery systems.To assess the stability of crosslinked structures, gels were subjected to subsequent drying (at 25, 60, and 105 °C) and water sorption (at 25 °C) cycles. Reduction of the swelling degree and respective calculated M C values as well as lessening of the initial rate of water sorption after each drying cycle indicate the formation of additional crosslinks.

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mentioning

confidence: 99%

Characterization of cryogenically slightly crosslinked biomedical poly(vinyl alcohol) gels

Staško¹,

Kalniņš²,

Bērziņa-Cimdiņa³

2012

Proc. Estonian Acad. Sci.

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Development of Poly(vinyl alcohol) Based Systems for Wound Dressings

Cited by 1 publication

References 3 publications

Characterization of cryogenically slightly crosslinked biomedical poly(vinyl alcohol) gels

Characterization of cryogenically slightly crosslinked biomedical poly(vinyl alcohol) gels

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