Development of polyurethane antimicrobial coatings by composition with phenolic-, ionic- and copper-based agents

Costa, Tiago; Veiga, Maria Isabel; Osório, Nuno S.; Neves, Nuno M.; Ribeiro, Helena Aguilar; Fraga, Alexandra G.

doi:10.1016/j.jmrt.2023.04.243

Cited by 5 publications

(2 citation statements)

References 86 publications

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“…The plates were incubated at 32°C or 35°C for 40–48 h. Following this incubation period, the number of CFU were counted. As described by Costa et al (2023) , the antimicrobial activity (R) was calculated by subtracting the average of common logarithm of the number of viable colonies recovered from untreated materials 24 h after inoculation and the average of common logarithm of the number of viable colonies recovered from treated materials after 24 h of inoculation. In addition, the microbial ratio (MR) was determined to quantify the percentage of the microbial burden present in each treated materials relative to the bacterial burden in untreated materials (control lacquer-films).…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial properties of hindered amine light stabilizers in polymer coating materials and their mechanism of action

Costa,

Sampaio-Marques,

Neves

et al. 2024

Front. Bioeng. Biotechnol.

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UV-stabilizers are a class of additives that provide extended polymer resistance to UV-degradation, but have also been suggested to have antimicrobial activity, potentially preventing the spread of pathogens, and inhibiting microbial-induced biodegradation. In this work, we incorporated different UV-stabilizers, a hindered amine light stabilizer (HALS), Tinuvin 770 DF and Tinuvin PA 123, or a hybrid HALS/UV-absorber, Tinuvin 5151, in polyurethane formulations to produce lacquer-films, and tested their antimicrobial activity against Staphylococcus aureus (methicillin-resistant and -sensitive strains), Escherichia coli and Candida albicans. Lacquer-films incorporated with Tinuvin 770 DF showed strong antimicrobial performance against bacteria and fungi, while maintaining cytocompatibility. The mechanism of action revealed a positive relationship between Tinuvin 770 DF concentration, microbial death, and reactive nitrogen species (RNS), suggesting that RNS produced during autoxidation of Tinuvin 770 DF is responsible for the antimicrobial properties of this UV-stabilizer. Conversely, lacquer-films incorporated with Tinuvin 5151 or Tinuvin PA 123 exhibited no antimicrobial properties. Collectively, these results highlight the commercial potential of Tinuvin 770 DF to prevent photo- and biodegradation of polymers, while also inhibiting the spread of potentially harmful pathogens. Furthermore, we provide a better understanding of the mechanism underlying the biocidal activity of HALS associated to autooxidation of the amine group.

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Section: Methodsmentioning

confidence: 99%

Antimicrobial properties of hindered amine light stabilizers in polymer coating materials and their mechanism of action

Costa,

Sampaio-Marques,

Neves

et al. 2024

Front. Bioeng. Biotechnol.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The plates were incubated at 32 °C or 35 °C for 40-48 h. Following this incubation period, the number of CFU were counted. As described by Costa et al (2023), the antimicrobial activity (R) was calculated by subtracting the average of common logarithm of the number of viable colonies recovered from untreated materials 24 h after inoculation and the average of common logarithm of the number of viable colonies recovered from treated materials after 24 h of inoculation. In addition, the microbial ratio (MR) was determined to quantify the percentage of the microbial burden present in each treated materials relative to the bacterial burden in untreated materials (control lacquer-films).…”

Section: Evaluation Of the Antimicrobial Activity Of Hals-based Lacqu...mentioning

confidence: 99%

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Polyurethane based on plant phenols

Zhang,

Lyu,

et al. 2024

High Performance Plant Phenol-Based Polymers

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Development of polyurethane antimicrobial coatings by composition with phenolic-, ionic- and copper-based agents

Cited by 5 publications

References 86 publications

Antimicrobial properties of hindered amine light stabilizers in polymer coating materials and their mechanism of action

Antimicrobial properties of hindered amine light stabilizers in polymer coating materials and their mechanism of action

DataSheet1.pdf

Polyurethane based on plant phenols

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