2023
DOI: 10.3390/nano13121831
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Development of Positively Charged Poly-L-Lysine Magnetic Nanoparticles as Potential MRI Contrast Agent

Abstract: A colloidal solution of magnetic nanoparticles (MNPs) modified with biocompatible positively charged poly-L-lysine (PLL) with an oleate (OL) layer employed as an initial coating was produced as a potential MRI contrast agent. The effect of various PLL/MNPs’ mass ratios on the samples’ hydrodynamic diameter, zeta potential, and isoelectric point (IEP) was studied by the dynamic light-scattering method. The optimal mass ratio for MNPs’ surface coating was 0.5 (sample PLL0.5-OL-MNPs). The average hydrodynamic par… Show more

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“…Magnetic resonance imaging (MRI) is widely used to assess implants and the surrounding tissue [16]. During MRI examination, a high magnetic field intensity can magnetize the metallic implants, which results in artifacts and signal loss, hinders the imaging of surrounding structures, and finally affects the diagnosis [17].…”
Section: Introductionmentioning
confidence: 99%
“…Magnetic resonance imaging (MRI) is widely used to assess implants and the surrounding tissue [16]. During MRI examination, a high magnetic field intensity can magnetize the metallic implants, which results in artifacts and signal loss, hinders the imaging of surrounding structures, and finally affects the diagnosis [17].…”
Section: Introductionmentioning
confidence: 99%