In recent decades, in Italy, as in the international context, the phenomenon of disused industrial buildings has acquired considerable dimensions, with inevitable social, urban and economic repercussions. At the same time, the cultural debate has increased awareness of the problem and the strategic role that disused industrial sites can play in meeting new needs. This paper provides a comprehensive analysis of the abandoned Montedison industrial complex in Porto Empedocle, Sicily. It examines the history, current state, and potential future uses of this former industrial site. The research is well-documented, incorporating historical context, architectural details, and considerations for urban redevelopment. This paper effectively discusses the broader issues surrounding the reuse of abandoned industrial areas, making it relevant beyond just this specific case study. Insights are drawn from qualitative research, with evidence derived from document sources, archival records, direct participants, and semi-structured interviews. The main objectives achieved are as follows: expanding knowledge of the decommissioned site; proposing; from a quality and sustainability perspective; a model for managing the decision-making process; identifying some project ideas to initiate the decision-making process. The understanding of historical industrial buildings is relevant to the present and enables the implementation of urban transformation processes consistent with contemporary challenges.