Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: Can the simple nutritional supplements be used as first line therapeutic agents for prophylaxis/therapy?

Ankola, D. D.; Viswanad, Bhoomi; Bhardwaj, V.; Ramarao, P.; Kumar, M. N. V. Ravi

doi:10.1016/j.ejpb.2007.03.010

Cited by 104 publications

(92 citation statements)

References 23 publications

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“…The entrapment efficiency was found to be about 70% of initial CoQ 10 entrapment (~35 mg CoQ10/100 mg polymer). CoQ 10 entrapped PLGA nanoparticles were proven efficacious in diabetic and renal hypertensive models by preventing the free radicals, inflammation and lipid abnormalities (Ankola et al 2007, Ratnam et al 2008, Ratnam et al 2011). …”

Section: Histological Studiesmentioning

confidence: 99%

“…Even though a precise mechanism of action of CoQ 10 in MI is not known, in general it is attributed to its 13 antioxidant nature, ability to minimize inflammation, improve endothelium function (Dai et al, 2011;Lee et al, 2012). We have previously reported the efficacy of CoQNPs in other experimental models (Ankola et al, 2007;Ratnam et al, 2009) however a more systematic understanding is required on their therapeutic potential before much efforts are put in to prove the performance of these compounds that are in general high dose molecules and currently in use as supplements.…”

Section: Coq 10 Loaded Nanoparticle Efficacy Studymentioning

confidence: 99%

“…However, CoQ 10 is still seeking solutions to overcome poor oral bioavailability problems (Beg et al, 2010). Strategies to improve gastrointestinal absorption have been previously studied with proven success in several pathologies (Ankola et al, 2007;Ratnam et al, 2009). …”

Section: Introductionmentioning

confidence: 99%

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Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia

Simón-Yarza

Tamayo

Benavides

et al. 2013

International Journal of Pharmaceutics

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Myocardial ischemia (MI) remains one of the leading causes of death worldwide.Angiogenic therapy with the vascular endothelial growth factor (VEGF) is a promising strategy to overcome hypoxia and its consequences. However, from the clinical data it is clear that fulfillment of the potential of VEGF warrants a better delivery strategy. On the other hand, the compelling evidences of the role of oxidative stress in diseases like MI encourage the use of antioxidant agents. Coenzyme Q 10 (CoQ 10 ) due to its role in the electron transport chain in the mitochondria seems to be a good candidate to manage MI but is associated with poor biopharmaceutical properties seeking better delivery approaches.The female Sprague Dawley rats were induced MI and were followed up with VEGF microparticles intramyocardially and CoQ 10 nanoparticles orally or their combination with appropriate controls. Cardiac function was assessed by measuring ejection fraction before and after three months of therapy.Results demonstrate significant improvement in the ejection fraction after three months with both treatment forms individually; however the combination therapy failed to offer any synergism. In conclusion, VEGF microparticles and CoQ 10 nanoparticles can be considered as promising strategies for managing MI.

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Section: Histological Studiesmentioning

confidence: 99%

Section: Coq 10 Loaded Nanoparticle Efficacy Studymentioning

confidence: 99%

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Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia

Simón-Yarza

Tamayo

Benavides

et al. 2013

International Journal of Pharmaceutics

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“…However identical cellular uptake was noticed for both the cases. This method has been used to encapsulate a wide variety of hydrophobic drugs including coenzyme Q [14], ellagic acid [15], estradiol [9], taxol [16,17], ellagic acid [15] and camptothecin [18].…”

Section: Zeta Potential Of Nanocapsulesmentioning

confidence: 99%

Formulation of Catechin Hydrate Nanocapsule and Study of its Bioavailability

Samanta¹,

Bidyut²,

yopadhyay³

et al. 2016

Med chem (Los Angeles)

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Flavonoid is a polyphenolic antioxidant used to treat free radical mediated tissue damage. So flavonoids are the good targets for treatment of many diseases like cancer, toxicity health hazards, neurodegenaration etc. Drug delivery of flavonoid is the novel approach where dosing and drug toxicity can be minimized. Antioxidant Catechin Hydrate (CH) is choosen to make drug delivery vehicle: nanocapsules either alone or in combination with chelator sodium meta borate (SMB) within biodegradable poly-lactide-co-glycolide (PLGA). Sizes of the prepared particles were determined through scanning and atomic force microscopy where less than 50 nm particle sizes were revealed. Bioavailability in serum study determines that shelf life of CH can be increased with nanocapsule delivery compared to free drug. Results demonstrate the efficacy of Nanocapsulated CH to be a potent vehicle for tissue targeting.

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“…Some approaches have included the preparation of nanoparticles incorporating CoQ 10 (Hsu et al, 2003;Ankola et al, 2007), solubilization in a blend of sorbitan monooleate, polysorbate 80, medium chain triglycerides, propylene glycol, -tocopherol and poly vinyl pyrrolidone (Chopra et al, 1998), preparation of redispersible dry emulsion (Takeuchi et al, 1992), solid dispersion of CoQ 10 with Eudragit® (Nazzal et al, 2002), and fine oil-in-water emulsion via the development of a self-emulsifying drug delivery system (Kommuru et al, 2001). The most recent preparation of CoQ 10 is All-Q ® 10% CWS/S, which is based on food grade starch (Ullmann et al, 2005).…”

Section: Complex Of Coq 10 With β-Cyclodextrinementioning

confidence: 99%

Poultry Products with Increased Content of CoQ10 Prepared from Chickens Fed with Supplemental CoQ10

Križman¹,

Prošek²,

Šmidovnik³

et al. 2012

Trends in Vital Food and Control Engineering

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Development of potent oral nanoparticulate formulation of coenzyme Q10 for treatment of hypertension: Can the simple nutritional supplements be used as first line therapeutic agents for prophylaxis/therapy?

Cited by 104 publications

References 23 publications

Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia

Functional benefits of PLGA particulates carrying VEGF and CoQ10 in an animal of myocardial ischemia

Formulation of Catechin Hydrate Nanocapsule and Study of its Bioavailability

Poultry Products with Increased Content of CoQ10 Prepared from Chickens Fed with Supplemental CoQ10

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