To provide a reliable and comprehensive data reference for core geometry design of graphite-moderated and low-enriched uranium fueled molten salt reactors, the influences of geometric parameters on the temperature coefficient of reactivity (TCR) at an assembly level were characterized. A four-factor formula was introduced to explain how different reactivity coefficients behave in terms of the fuel salt volume fraction and assembly size. The results show that the fuel salt temperature coefficient (FSTC) is always negative owing to a more negative fuel salt density coefficient in the over-moderated region or a more negative Doppler coefficient in the under-moderated region. Depending on the fuel salt channel spacing, the graphite moderator temperature coefficient (MTC) can be negative or positive. Furthermore, an assembly with a smaller fuel salt channel spacing is more likely to exhibit a negative MTC. As the fuel salt volume fraction increases, the negative FSTC first weakens and then increases, owing to the fuel salt density effect gradually weakening from negative to positive feedback and then decreasing. Meanwhile, the MTC weakens as the thermal utilization coefficient caused by the graphite temperature effect deteriorates. Thus, the negative TCR first weakens and then strengthens, mainly because of the change in the fuel salt density coefficient. As the assembly size increases, the magnitude of the FSTC decreases monotonously owing to a monotonously weakened fuel salt Doppler coefficient, whereas the MTC changes from gradually weakened negative feedback to gradually enhanced positive feedback. Then, the negative TCR weakens. Therefore, to achieve a proper negative TCR, particularly a negative MTC, an assembly with a smaller fuel salt channel spacing in the under-moderated region is strongly recommended.