For economic reasons, the nuclear industry is witnessing premature closure of nuclear power plants, despite excellent safety records. Operations and maintenance activities are some of the largest costs in operating legacy lightwater plants. By reducing operations and maintenance costs, nuclear energy can become more economically competitive with other energy sources. This can be achieved in part by leveraging machine-learning and artificial intelligence technologies to develop data-driven algorithms to better diagnose potential faults within the system. The improved accuracy of the models can lead to a reduction in unnecessary maintenance, thus reducing costs associated with parts, labor, and unnecessary planned, forced, or extended outages.To address these challenges, the goal of this project is to perform research and development in the area of digital monitoring (i.e., the application of advanced sensor technologies, particularly wireless sensor technologies, and data-science-based analytic capabilities) to advance online monitoring and predictive maintenance in nuclear plants and improve plant performance (efficiency gain and economic competitiveness). This report summarizes the Fiscal Year 2020 research progress encompassing the (1) different wireless vibration sensor and data indicators used to assess the health of a plant asset; (2) development of diagnostic models for fault detection; and (3) development of prognostic models for estimating the health of the system up to 7 days ahead.