Development of pulmonary abnormalities in patients with common variable immunodeficiency: associations with clinical and immunologic factors

British Thoracic Society Guideline for bronchiectasis in adults

“…380 †This may need tailored in light of the local prevalence rates of NTM infections and in some centres may need undertaken on a regular basis. Further cultures at exacerbation may be appropriate.…”

Pulmonary radiologic findings in common variable immunodeficiency: clinical and immunological correlations

“…3-5 Ten years ago it was established by Routes and colleagues that interstitial lung disease (ILD) significantly worsens survival in CVID. 6 However, established CVID lung disease has proven difficult to treat and is not reversed by conventional immunoglobulin (Ig) replacement therapy in most patients, 7 though it may improve pulmonary function testing. 8,9 …”

“…7,10-12 Lung pathology may reveal ILD with manifestations of pulmonary lymphoid hyperplasia (PLH), which includes follicular bronchiolitis, lymphocytic interstitial pneumonitis (LIP), and nodular lymphoid hyperplasia. 6,13-15 Additionally, granulomatous lung disease is found in many cases 16-18 and organizing pneumonia (OP) in some.…”

A glance on recent progresses in diagnosis and treatment of primary immunodeficiencies/ Progrese recente în diagnosticul şi tratamentul imunodeficienţelor primare

“…However, there are patients who are not able to cope with these rules. Parameters identified so far for not being able to cope with the rules are (i) patient's residual levels of IgA, (ii) serum concentration of mannose-binding lectin, (iii) the polymorphism of the neonatal FcRn receptor, and (iv) B cell defects (61)(62)(63)(64)(65). In some patients the optimisation of replacement therapy might require measurement of e.g.…”