Development of quality standards and standardization of dental medicated film containing succinic acid and cethylpyridinium chloride

Herbal sedatives have been popular for several centuries, and the accumulated knowledge that has been passed down from generation to generation laid the foundation for the development of traditional medicine, and over time for such a science as herbal medicine. Herbal sedatives have a wide range of therapeutic effects, are well tolerated and have no serious adverse reactions, and are not addictive. According to statistical data on the incidence of the population by main classes and individual diseases for 2010-2018, the number of patients with diseases of the nervous system is growing annually, along with this, the need for sedative drugs is increasing. In this regard, the search and development of effective and safe medicines based on medicinal plant raw materials is an urgent area [1, 2]. Pharmaceutical infusions and decoctions, according to the order of the Ministry of Health of the Russian Federation No. 751n dated October 26, 2015, have a shelf life of 2 days, which significantly limits the possibility of their use. The production of films based on aqueous extracts from medicinal plant raw materials will make it possible to obtain more stable drugs, in addition, films have a number of advantages over other dosage forms. Films containing biologically active substances of plant origin have received the unofficial name phytofilms, which are a type of transdermal therapeutic systems. Phytofilms are hydrophilic systems that swell when in contact with water (or biological fluid), absorbing it in a certain amount, which leads to the dissolution of biologically active substances. They differ from synthetic polymeric therapeutic systems in that phytofilms are made in the form of matrix transdermal therapeutic systems on carriers of natural origin (gelatin, collagen, sodium alginate, agar-agar, etc.), which makes them safer [3, 4].

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Development of the Composition and Technology of Sedative Films

Zamakhaeva

Oleshko

Yaborova

et al. 2021

Mediko-farmacevtičeskij žurnal "Pulʹs"

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The use of carboxytherapy in the complex treatment of periodontal diseases

et al. 2022

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Relevance. Today, inflammatory periodontal diseases are one of the most common pathologies seen at dental appointments. During the treatment of these diseases, the main goal of the therapy is to reduce the intensity of inflammatory manifestations.Materials and methods. The article presents the results of the application of the original method of carboxytherapy to reduce the inflammatory component at the initial phase of the treatment of inflammatory periodontal diseases.The technique suggests the injection of 0.5–1.0 ml of medical carbon dioxide into the vestibular mucobuccal fold and the dental papillae region with a special injector. The study was conducted at the department of prosthodontics of Samara State Medical University. The study divided the patients into two groups. The control group underwent professional oral hygiene, and the main-group patients had an additional carboxytherapy treatment developed by the authors. The study evaluated the effectiveness of the treatment using the OHI-S, PMA, and Muhllemann indices and the restoration of blood filling using the periodontal bloo d flow assessment method.Results. After the treatment, the main group showed a statistically significant decrease in the assessed indices and blood circulation restoration in the periodontium, which indicates a significant effect of the method used. Allergic and toxic effects on the mucous membrane did not manifest in the carboxytherapy group during the observation period. Patients did not complain about pain and discomfort.Conclusion. So, based on the conducted studies, we can conclude that the method of carboxytherapy is highly effective as one of the elements of the c omplex treatment of periodontal diseases.

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Evaluation of the clinical efficacy of the composition based on superoxide dismutase and cluster silver in combination with an energy protector in therapy chronic generalized periodontitis

Popkov,

Leontyev,

Zadorozhny

et al. 2024

Stomatol. vseh

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The paper presents the results of studies on the effect of a drug composition in the form of gel, which includes two main components: a key enzyme of antioxidant defense of the body — superoxide dismutase (SOD) and a broad-spectrum antibacterial component in relation to aerobic, anaerobic, gram-positive and gram-negative microflora, including antibiotic-resistant — cluster silver and a metabolic drug on the therapeutic efficacy of the use of these drugs in the complex pharmacotherapy of patients with chronic generalized periodontitis (CHGP) moderate to severe severity. Based on the data of clinical symptoms (pain, hyperemia, pathological mobility, etc.), indicators of the index assessment of the state of periodontal status (PI, PMA), the mathematized Schiller-Pisarev test and the index of interdental papillae bleeding (SBI) according to Muhlemann-Cowell observed the dynamics of changes in the state of the oral cavity and periodontal tissues in patients with CHGР. It was established that the pharmacotherapy with the additional inclusion in the complex of drugs of traditional drug therapy of a gel, including SOD and cluster silver, as well as a drug of metabolic action, contributed to a more rapid relief of acute inflammatory processes in periodontal tissues, a decrease in the severity of destructive changes, a decrease in the manifestation of pathological symptoms, improving the reparative regeneration of periodontal support tissues and increasing the effectiveness of treatment of patients with CHGP.

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Development of quality standards and standardization of dental medicated film containing succinic acid and cethylpyridinium chloride

Abstract: The quality standards were determined and standardization of model samples of the dental medicated film containing succinic acid and cetylpyridinium chloride was carried out taking into account the requirements of the State Pharmacopoeia of the Russian Federation of the XIV edition.

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Development of the Composition and Technology of Sedative Films

Development of the Composition and Technology of Sedative Films

The use of carboxytherapy in the complex treatment of periodontal diseases

Evaluation of the clinical efficacy of the composition based on superoxide dismutase and cluster silver in combination with an energy protector in therapy chronic generalized periodontitis

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