Development of Quercetin-loaded polyvinyl-alcohol/gelatin nanofibrous coating over Ti–6Al–4V bone implant with improved antibacterial and bioactive characteristics

Dey, Sovan; Singh, Amit Kumar; Smita, Soumya Shuvra; Biswas, Amit; Kumar, Sachin

doi:10.1007/s10853-024-09899-5

J Mater Sci

2024

DOI: 10.1007/s10853-024-09899-5

|View full text |Cite

Development of Quercetin-loaded polyvinyl-alcohol/gelatin nanofibrous coating over Ti–6Al–4V bone implant with improved antibacterial and bioactive characteristics

Sovan Dey,

Amit Kumar Singh,

Soumya Shuvra Smita

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Development of Silk Fibroin/Gelatin/PCL tri-polymeric complex nanofibrous two-dimensional mat for epithelial tissue regeneration

Smita,

Pramanik

2025

Chemical Engineering Journal

View full text Add to dashboard Cite

Development of Silk Fibroin/Gelatin/PCL tri-polymeric complex nanofibrous two-dimensional mat for epithelial tissue regeneration

Smita,

Pramanik

2025

Chemical Engineering Journal

View full text Add to dashboard Cite

Development and characterization of electrospun curcumin-loaded PVA/gelatin based nanofibers scaffolds for skin tissue engineering

Sahani,

Smita,

Dey

et al. 2024

Journal of Bioactive and Compatible Polymers

View full text Add to dashboard Cite

Chronic skin wounds have a profound impact on the global population, affecting over 40 million individuals and resulting in healthcare expenditures exceeding $20 billion annually by 2025. Researchers have developed wound dressings using biocompatible polymers that possess bioactive properties to combat this pressing issue. The present research focuses on fabricating a nanofiber-based composite structure made of Polyvinyl alcohol (PVA) and Gelatin, incorporating varying concentrations of curcumin (0.25, 0.5, and 0.75 mg/ml). The fabrication process employed electrospinning techniques to create nanofiber-based scaffolds that closely mimic the native structure of the extracellular matrix (ECM) found in the skin. The developed nanofiber mats underwent comprehensive characterization through a sequence of in-vitro experiments, encompassing SEM imaging, Fourier transform infrared spectroscopy (FTIR), in-vitro release studies, and evaluation of tensile strength, swelling, and degradation. SEM images revealed a notable reduction in the mean fiber diameter, swelling potential and extent of degradation following the addition of curcumin. Regarding drug release, curcumin demonstrated a biphasic release profile in phosphate buffer (pH 7.4) and Tween 80 solutions. The PVA/gelatin (PG) mats containing curcumin displayed strong antimicrobial effects against Gram-negative E. coli and Gram-positive S. aureus. The biocompatibility of the membranes was further confirmed through cytocompatibility testing utilizing the L929 cell line. Overall, this research indicates that wound dressings made from nanofibers composed of polyvinyl alcohol (PVA) and gelatin, incorporating curcumin, exhibit considerable potential for treating cutaneous wounds. However, additional research is necessary to determine the effectiveness of these dressings in vivo.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Development of Quercetin-loaded polyvinyl-alcohol/gelatin nanofibrous coating over Ti–6Al–4V bone implant with improved antibacterial and bioactive characteristics

Cited by 2 publications

References 42 publications

Development of Silk Fibroin/Gelatin/PCL tri-polymeric complex nanofibrous two-dimensional mat for epithelial tissue regeneration

Development of Silk Fibroin/Gelatin/PCL tri-polymeric complex nanofibrous two-dimensional mat for epithelial tissue regeneration

Development and characterization of electrospun curcumin-loaded PVA/gelatin based nanofibers scaffolds for skin tissue engineering

Contact Info

Product

Resources

About