Development of raft-forming liquid formulations loaded with ginger extract-solid dispersion for treatment of gastric ulceration

Matchimabura, Nattawipa; Praparatana, Rachanida; Issarachot, Ousanee; Oungbho, Kwunchit; Wiwattanapatapee, Ruedeekorn

doi:10.1016/j.heliyon.2024.e31803

Heliyon

2024

DOI: 10.1016/j.heliyon.2024.e31803

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Development of raft-forming liquid formulations loaded with ginger extract-solid dispersion for treatment of gastric ulceration

Nattawipa Matchimabura,

Rachanida Praparatana,

Ousanee Issarachot

et al.

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Advancing the Physicochemical Properties and Therapeutic Potential of Plant Extracts Through Amorphous Solid Dispersion Systems

Budiman,

Hafidz,

Azzahra

et al. 2024

Polymers

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Plant extracts demonstrate significant potential as a rich source of active pharmaceutical ingredients, exhibiting diverse biological activities and minimal toxicity. However, the low aqueous solubility of extracts and their gastrointestinal permeability, as well as their poor oral bioavailability, limit clinical advancements due to drug delivery problems. An amorphous solid dispersion (ASD) delivers drugs by changing an active pharmaceutical ingredient (API) into an amorphous state to increase the solubility and availability of the API to the body. This research aimed to analyze and summarize the successful advancements of ASD systems derived from plant extracts, emphasizing characterization and the effects on dissolution and pharmacological activity. The results show that ASD systems improve phytoconstituent dissolution, bioavailability, and stability, in addition to reducing dose and toxicity. This research demonstrates the significance of ASD in therapeutic formulations to augment the pharmacological activities and efficacy of medicinal plant extracts. The prospects indicate promising potential for therapeutic applications utilizing ASD systems, alongside medicinal plant extracts for clinical therapy.

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Advancing the Physicochemical Properties and Therapeutic Potential of Plant Extracts Through Amorphous Solid Dispersion Systems

Budiman,

Hafidz,

Azzahra

et al. 2024

Polymers

View full text Add to dashboard Cite

show abstract

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Development of raft-forming liquid formulations loaded with ginger extract-solid dispersion for treatment of gastric ulceration

Cited by 1 publication

References 55 publications

Advancing the Physicochemical Properties and Therapeutic Potential of Plant Extracts Through Amorphous Solid Dispersion Systems

Advancing the Physicochemical Properties and Therapeutic Potential of Plant Extracts Through Amorphous Solid Dispersion Systems

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