“…9,10,13 Additionally, drug solubility and the need for loading or maintenance dosage should be reviewed because these factors are important for determining appropriate weight/size descriptors (i.e., TBW, ideal body weight, adjusted body weight, body surface area) to calculate the final dose. 10,14,15 In obese children requiring loading doses, for hydrophilic medications, use ideal body weight; for lipophilic medications, use TBW; for partially lipophilic medications, use adjusted body weight. 10,15 Lean body weight should be used for maintenance doses because it is most closely related to lean body mass.…”