Development of reference equations for spirometry in japanese children aged 6–18 years

Takase, Masato; Sakata, Hiroshi; Shikada, Masahiro; Tatara, Katsunori; Fukushima, Toshirou; Miyakawa, Tomoo

doi:10.1002/ppul.22536

Cited by 32 publications

(43 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…12 Consistent with previous reports,4–11 14 23 24 we confirmed that the NICHD classification of BPD14 was useful for predicting the impairment of long-term lung function (table 2). …”

Section: Discussionsupporting

confidence: 91%

“…Lung function results with respective BPD classification are shown in table 2. After adjustment for age, sex and height using a reference for Japanese children,12 children who were born ELBW had a lower baseline spirometry, as shown by a reduction in the per cent predicted compared with the reference for Japanese children. There was a trend towards a decreased level of all lung function variables, except for FEV 1 /FVC ratio, as the grade of BPD increased.…”

Section: Resultsmentioning

confidence: 95%

“…A decrease in spirometric parameters below their relevant 5th centiles is thought to be consistent with pulmonary defects according to the American Thoracic Society and European Respiratory Society consensus 13. According to reference equations for spirometry in Japanese children aged 6–18 years, cut-off values equivalent to the 5th centile were 80% for FVC predicted and the FEV 1 /FVC ratio 12. Therefore, we defined a restrictive abnormality as FVC <80% predicted with an FEV 1 /FVC ratio ≥80%, obstructive abnormality as an FEV 1 /FVC ratio <80% with FVC ≥80% predicted and mixed abnormality as FVC <80% predicted with an FEV 1 /FVC ratio <80%.…”

Section: Methodsmentioning

confidence: 96%

“…During spirometry, attempts were made to achieve at least three acceptable and two repeatable forced expiratory manoeuvres. Results of spirometric data are expressed as per cent predicted for age, height and sex relative to Japanese children 12. A decrease in spirometric parameters below their relevant 5th centiles is thought to be consistent with pulmonary defects according to the American Thoracic Society and European Respiratory Society consensus 13.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Perinatal factors associated with long-term respiratory sequelae in extremely low birthweight infants

Hirata

Nishihara

Shiraishi

et al. 2015

Arch Dis Child Fetal Neonatal Ed

View full text Add to dashboard Cite

show abstract

“…12 Consistent with previous reports,4–11 14 23 24 we confirmed that the NICHD classification of BPD14 was useful for predicting the impairment of long-term lung function (table 2). …”

Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 95%

Section: Methodsmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Perinatal factors associated with long-term respiratory sequelae in extremely low birthweight infants

Hirata

Nishihara

Shiraishi

et al. 2015

Arch Dis Child Fetal Neonatal Ed

View full text Add to dashboard Cite

show abstract

“…Table 4 compared the predicted values of FVC, FEV 1 , PEF and MMEF obtained from the developed equations and the existing reference prediction equations of Kui Feng et al [11], Meng-Chiao Tsai et al [8], Masato Takase et al [26], John Hankinson et al [27], and Mary S. M. Ip et al [6] based on the validation subset. No significant difference was found in males, indicating the developed predictive models were comparable to the existing ones in males, whereas in females non-significance was found only for PEF.…”

Section: Resultsmentioning

confidence: 99%

Predictive Equations Using Regression Analysis of Pulmonary Function for Healthy Children in Northeast China

Wang

Dong

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

BackgroundThere have been few published studies on spirometric reference values for healthy children in China. We hypothesize that there would have been changes in lung function that would not have been precisely predicted by the existing spirometric reference equations. The objective of the study was to develop more accurate predictive equations for spirometric reference values for children aged 9 to 15 years in Northeast China.Methodology/Principal FindingsSpirometric measurements were obtained from 3,922 children, including 1,974 boys and 1,948 girls, who were randomly selected from five cities of Liaoning province, Northeast China, using the ATS (American Thoracic Society) and ERS (European Respiratory Society) standards. The data was then randomly split into a training subset containing 2078 cases and a validation subset containing 1844 cases. Predictive equations used multiple linear regression techniques with three predictor variables: height, age and weight. Model goodness of fit was examined using the coefficient of determination or the R2 and adjusted R2. The predicted values were compared with those obtained from the existing spirometric reference equations. The results showed the prediction equations using linear regression analysis performed well for most spirometric parameters. Paired t-tests were used to compare the predicted values obtained from the developed and existing spirometric reference equations based on the validation subset. The t-test for males was not statistically significant (p>0.01). The predictive accuracy of the developed equations was higher than the existing equations and the predictive ability of the model was also validated.Conclusion/SignificanceWe developed prediction equations using linear regression analysis of spirometric parameters for children aged 9–15 years in Northeast China. These equations represent the first attempt at predicting lung function for Chinese children following the ATS/ERS Task Force 2005 guidelines on spirometry standardization.

show abstract

Longitudinal data of serum creatine kinase levels and motor, pulmonary, and cardiac functions in 337 patients with Duchenne muscular dystrophy

Awano,

Nambu,

Itoh

et al. 2024

Muscle and Nerve

View full text Add to dashboard Cite

Introduction/AimsDuchenne muscular dystrophy (DMD) presents with skeletal muscle weakness, followed by cardiorespiratory involvement. The need for longitudinal data regarding DMD that could serve as a control for determining treatment efficacy in clinical trials has increased notably. The present study examined the longitudinal data of Japanese DMD patients collectively and assessed individual patients with pathogenic variants eligible for exon‐skipping therapy.MethodsPatients with DMD who visited Kobe University Hospital between March 1991 and March 2019 were enrolled. Data between the patients' first visit until age 20 years were examined.ResultsThree hundred thirty‐seven patients were included. Serum creatine kinase levels showed extremely high values until the age of 6 years and a rapid decline from ages 7–12 years. Both the median 10‐m run/walk velocity and rise‐from‐floor velocity peaked at the age of 4 years and declined with age. The values for respiratory function declined from the age of 11 years. The median left ventricular ejection fraction was >60% until the age of 12 years and rapidly declined from ages 13–15 years. Examination of the relationship between pathogenic variants eligible for exon‐skipping therapy and longitudinal data revealed no characteristic findings.DiscussionWe found that creatine kinase levels and motor, respiratory, and cardiac functions each exhibited various changes over time. These findings provide useful information about the longitudinal data of several outcome measures for patients with DMD not receiving corticosteroids. These data may serve as historical controls in comparing the natural history of DMD patients not on regular steroid use in appropriate clinical trials.

show abstract

Development of reference equations for spirometry in japanese children aged 6–18 years

Abstract: We recommend the use of this new set of prediction equations together with suggested cut-off values, for assessment of spirometry in Japanese children and adolescents.

Cited by 32 publications

References 25 publications

Perinatal factors associated with long-term respiratory sequelae in extremely low birthweight infants

Perinatal factors associated with long-term respiratory sequelae in extremely low birthweight infants

Predictive Equations Using Regression Analysis of Pulmonary Function for Healthy Children in Northeast China

Longitudinal data of serum creatine kinase levels and motor, pulmonary, and cardiac functions in 337 patients with Duchenne muscular dystrophy

Contact Info

Product

Resources

About