Development of remineralizing, antibacterial dental materials

Mehdawi, Idris Mohamed; Neel, Ensanya A. Abou; Valappil, Sabeel P.; Palmer, G.; Salih, Vehid; Pratten, Jonathan; Spratt, DA; Young, Alison

doi:10.1016/j.actbio.2009.03.030

Cited by 61 publications

(43 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1,2 Microorganisms accumulate more readily on composite resins compared to amalgam and glass ionomer restoratives. 3 Various researchers have attempted to reduce plaque accumulation on the surfaces of dental materials by incorporation of bactericidal agents such as chlorhexidine, 4 antibacterial monomer MDPB, 5,6 antibacterial monomer furanone 7 and other antibacterial fillers.…”

Section: Introductionmentioning

confidence: 99%

The Antibacterial Properties of Composite Resin Containing Nanosilver against Streptococcus mutans and Lactobacillus

Azarsina

Kasraei

Yousef-Mashouf

et al. 2013

The Journal of Contemporary Dental Practice

View full text Add to dashboard Cite

Aim:The aim was to evaluate the antibacterial properties of composite resin containing nanosilver against Streptococcus mutans (SM) and Lactobacillus (L). Materials and methods:Nanosilver was added to Z250 composite at 0.5 and 1% by weight. In order to confirm the homogenous distribution of the nanoparticles in the composite resin, SEM-EDX analysis was performed on one sample in each group. Z250 composite without nanosilver was used as control. Direct contact test was used to test the antibacterial properties of nanoparticle-loaded composites: 0.001 ml of 0.5 Mc Farland suspension of MS and L was placed on composite disks, and incubated for 1 hour in 5 to 10% CO 2 incubator at 37ºC. Samples were placed in 0.5 ml of sterile BHI broth and incubated for 2 hours in CO 2 incubator. Afterwards, 0.001 ml liquid from each medium was distributed on blood agar plates and incubated for 48 hours in CO 2 incubator. The numbers of bacterial colonies were counted visually. Data were analyzed using Two-way ANOVA and Tukey HSD test. Significance level was set at 0.05. Results:Addition of nanosilver to composite resin had a significant effect on reduction of the number of SM and L colonies (p = 0.000). The antibacterial properties of composite resins are different depending on the concentration of nanosilver (p = 0.014). Tukey test indicated that increase in the concentration of nanosilver caused the increase in antibacterial properties of composite resin. Conclusion:Addition of silver nanoparticles to Z250 composite could significantly inhibit the growth of Streptococcus mutans and Lactobacillus on the surface of this composite.Clinical significance: The addition of nanosilver to Z250 composite could inhibit the growth of SM and L on the surface of the restoration and therefore prevent the occurrence of secondary caries.

show abstract

Section: Introductionmentioning

confidence: 99%

The Antibacterial Properties of Composite Resin Containing Nanosilver against Streptococcus mutans and Lactobacillus

Azarsina

Kasraei

Yousef-Mashouf

et al. 2013

The Journal of Contemporary Dental Practice

View full text Add to dashboard Cite

show abstract

“…Indeed, it is notable that the ability of MTA to enable dentine bridge formation is caused not only by its biocompatibility but also its antibacterial properties, which subsequently generate an environment conducive for the pulpal tissue to undergo natural healing processes. 17 The incorporation of leachable antibacterials, such as chlorhexidine, 127 or the monomer methacryloyloxydodecylpyridiniium bromide (MDPB), 128,129 represent approaches that have already been commercialized. Other similar monomers, such as methacryloxylethyl cetyl dimethyl ammonium chloride (DMAE-CB) have recently been evaluated.…”

Section: Chemical Additives To Reduce Degradationmentioning

confidence: 99%

Can interaction of materials with the dentin-pulp complex contribute to dentin regeneration?

2010

View full text Add to dashboard Cite

Understanding outcomes of the interaction between a dental material and tooth tissue is important in terms not only of biocompatibility but also of the potential for the material to modulate the response of the tissue. This interaction is influenced by many factors, including the chemistry of the material and any of its eluted components or degradation products, and the manner in which the tissue responds to these agents. Past studies of this interaction have primarily been aimed at identifying cytotoxic effects. More recently, investigations have focused on specific cellular responses, and in particular, on understanding how the materials themselves actually may contribute to regenerative processes in the tooth. Recent work has demonstrated the solubilization of proteins from dentin exposed to certain materials, such as calcium hydroxide, mineral trioxide aggregate, and acidic solutions that relate to those used in dentin bonding agents, with the subsequent modulation by these proteins of gene expression in odontoblast-like cells. This work suggests that dentin bridge formation under such materials may be stimulated through this process. Thus, there is much merit in examining both how new dental materials can be developed and how more traditional ones can be modified to preferentially stimulate regenerative processes when preferred. This review summarizes current knowledge about the potential beneficial effects derived from the interaction of dental materials with the dentin-pulp complex, as well as potential future developments in this exciting field.

show abstract

“…[26] To eliminate any errors that could be caused by the swelling of the polymer, the z-potential as function time, z ¼ f(t), was recorded at constant ionic strength (1 mM KCl) prior to measuring z ¼ f(pH) in a 1 mM KCl supporting electrolyte solution. The streaming potential was generated by applying a steadily increasing pressure difference (Dp) from 30 to 250 mbar across a channel which was created by stacking a PTFE film with a preformed channel between two sample films.…”

Section: Surface Characteristics Of Titanium Doped Phosphate Glass/ Pmentioning

confidence: 99%

“…[17,18] Concentrating on bone tissue applications and considering polymer based materials (filled polymers and composites), hydroxyapatite, tricalcium phosphate (TCP) or Bioglass are the most popular used fillers. [16,[19][20][21][22][23][24][25][26] Other interesting materials are phosphate glasses, which have readily tuneable properties to improve cellular activity [27][28][29][30][31] or inhibit biofilm formation (antimicrobial glasses). [32][33][34] To date they were rarely used as polymer fillers.…”

mentioning

confidence: 99%

Tailoring Cell Behavior on Polymers by the Incorporation of Titanium Doped Phosphate Glass Filler

et al. 2010

Self Cite

View full text Add to dashboard Cite

Understanding tissue response to materials, to enable modulation and guided tissue regeneration is one of the main challenges in biomaterials science. Nowadays polymers, glasses, and metals dominate as biomaterials. Often native properties of those materials are not sufficient and there is a need to combine them, so as to modify and adjust their properties to the application. The primary aim of this study was to improve cell response to polymer (PLDL) using phosphate glass as filler (titanium doped phosphate glass). As a control β‐tricalcium phosphate (TCP) filler was used. Various concentrations of the filler were used (10–40 vol%). Wetting behavior, ζ‐potentials, mechanical and thermal properties, and human cells response to the materials were evaluated. Results showed that with increase in glass filler loading wettability improved, ζ‐potentials dropped, and increase in stiffness of materials was observed. Importantly cell culture experiments showed more developed and well spread cells on the samples with glass content up to 20 vol%. Cells responded much more positively to the glass filled samples than to TCP filled. However, expression of osteocalcin and osteopontin, proteins that indicate formation of the mineralized structures was positive for all the samples including pure PLDL. It was concluded that due to improved wetting behavior, lower ζ‐potentials, and specific chemistry of the glass filler it was possible to alter cells response, improve bioactivity of the polymer, and vary mechanical properties.

show abstract

Development of remineralizing, antibacterial dental materials

Cited by 61 publications

References 64 publications

The Antibacterial Properties of Composite Resin Containing Nanosilver against Streptococcus mutans and Lactobacillus

The Antibacterial Properties of Composite Resin Containing Nanosilver against Streptococcus mutans and Lactobacillus

Can interaction of materials with the dentin-pulp complex contribute to dentin regeneration?

Tailoring Cell Behavior on Polymers by the Incorporation of Titanium Doped Phosphate Glass Filler

Contact Info

Product

Resources

About