Development of Resistance to Antibiotics

Bhattacharjee, Mrinal K.

doi:10.1007/978-3-319-40746-3_2

Cited by 4 publications

(3 citation statements)

References 31 publications

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“…Fruit and vegetables are declared safe for human use if they have antibiotic residue under the selected maximum threshold. Similarly, fish and seafood heavily treated with antibiotics can be used after being housed in antibiotic-free water for some time, referred to as the withdrawal period (Bhattacharjee 2016). Unfortunately, the antibiotic residue is a much smaller problem than ARB and ARGs in food.…”

Section: Amr In the Foodmentioning

confidence: 99%

Rapid growth of antimicrobial resistance: the role of agriculture in the problem and the solutions

Stanley

Batacan

Bajagai

2022

Appl Microbiol Biotechnol

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The control of infectious diseases has always been a top medical priority. For years during the so-called antibiotic era, we enjoyed prolonged life expectancy and the benefits of superior pathogen control. The devastating failure of the medical system, agriculture and pharmaceutical companies and the general population to appreciate and safeguard these benefits is now leading us into a grim post-antibiotic era. Antimicrobial resistance (AMR) refers to microorganisms becoming resistant to antibiotics that were designed and expected to kill them. Prior to the COVID-19 pandemic, AMR was recognised by the World Health Organization as the central priority area with growing public awareness of the threat AMR now presents. The Review on Antimicrobial Resistance, a project commissioned by the UK government, predicted that the death toll of AMR could be one person every 3 seconds, amounting to 10 million deaths per year by 2050. This review aims to raise awareness of the evergrowing extensiveness of antimicrobial resistance and identify major sources of this adversity, focusing on agriculture’s role in this problem and its solutions. Keypoints • Widespread development of antibiotic resistance is a major global health risk. • Antibiotic resistance is abundant in agricultural produce, soil, food, water, air and probiotics. • New approaches are being developed to control and reduce antimicrobial resistance.

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Section: Amr In the Foodmentioning

confidence: 99%

Rapid growth of antimicrobial resistance: the role of agriculture in the problem and the solutions

Stanley

Batacan

Bajagai

2022

Appl Microbiol Biotechnol

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“…Widespread and particularly misuse of antibiotics, which is one of the main reasons of the high selective pressure on nosocomial pathogens, is a factor that accelerates the spread of multiple drug resistance including Enterococcus strains (Li and Webster, 2018). The selective pressure induced by the uncontrolled antibiotics for the treatment of infections in developing countries accelerates the selection of clonal variants with multiple drug resistance (Bhattacharjee, 2016). This rapid development in antibiotic resistance leads to the ineffectiveness of many antibiotics, which are widely used, in chemotherapy (Prestinaci, 2015).…”

Section: Evaluation Of Antimicrobial Activities Of Macrofungus Extract / Antibiotic Combinationsmentioning

confidence: 99%

Anti-Biofilm and Antimicrobial Activities of Five Edible and Medicinal Macrofungi Samples on Some Biofilm Producing Multi Drug Resistant Enterococcus Strains

Karaca

Cihan

Akata

et al. 2020

Turkish JAF Sci.Tech.

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It is commonly well-known that biofilms are the predominant mode of bacterial growth, reflected in the clinic observations, where approximately 80% of all bacterial infections are related to biofilms. Bacteria in biofilms are well protected against environmental stresses, antibiotics, disinfectants and the host’s immune system and are usually extremely difficult to eradicate. Due to common problems caused by biofilms, alternative anti-biofilm strategies must be developed. Enterococcus strains are able to form complex surface-associated communities (biofilms), which contribute to its resistance and persistence in both host and non-host environments, and are especially important in food processing and clinical environments. Enterococcus biofilms showed increased antimicrobial resistance to the most of antibiotics as compared to the planktonic bacteria, which make them difficult to combat. There is an increasing evidence that biofilms are often associated with infectious diseases. Novel anti-biofilm strategies must be designed to include natural bio products instead of common antibiotics. Mushrooms are a nutritionally functional foods and a source of pharmaceuticals having functions such as antitumor, immunomodulating, antioxidant, cardiovascular, anti-hypercholesterolemia, antiviral, antibacterial, anti-parasitic, antifungal, detoxification, hepatoprotective, and antidiabetic. In addition, they have a notable activity against biofilms. In this study, the antimicrobial and anti-biofilm activities of some medicinal and edible mushrooms, namely Morchella angusticeps Peck, Ganoderma lucidum (Curtis) P. Karst., Cerioporus squamosus (Huds.) Quél., Trametes versicolor (L.) Lloyd and Lentinula edodes (Berk.) Singer were screened against multi drug resistant Enterococcus strains. As a result, it was observed that these mushrooms have notable potency to develop alternative medicines to struggle infectious diseases and biofilms.

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“…Antibiotics, hailed as miracle drugs, have fulfilled an urgent medical need for a long time [1]. Unfortunately, a potentially disastrous prospect for clinical medicine today is the increase of bacterial resistance to conventional medical antibiotics, resulting from their overuse and inappropriate application [2,3].…”

Section: Introductionmentioning

confidence: 99%

Antibiotic-loaded MoS₂nanosheets to combat bacterial resistance via biofilm inhibition

et al. 2017

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The emergence of antibiotic resistance has resulted in an increasing difficulty treating clinical infections associated with biofilms formation, one of the key processes contributed to enhance antibiotic resistance in return. With the rapid development of nanotechnology, a new way to overcome antibiotic resistance was opened up. Based on multiple properties especially antibacterial potential of MoS₂ nanosheets that have aroused wide attention, herein, a novel antimicrobial agent to combat resistant gram-positive Staphylococcus aureus (S. aureus) and gram-negative Salmonella was prepared using chitosan functionalized MoS₂ nanosheets loading tetracycline hydrochloride drugs (abbreviated to CM-TH). The antibacterial and anti-biofilm activities of CM-TH nanocomposites expressed a synergy effect that the combination of nanomaterials and antibiotics were more efficient than both alone did. Particularly, the MIC values were generally decreased by a factor of dozens, suggesting CM-TH may become a possible alternative to traditional antibiotics in disrupting the biofilms and further to overcome antibiotic resistance in treating medical diseases.

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Development of Resistance to Antibiotics

Cited by 4 publications

References 31 publications

Rapid growth of antimicrobial resistance: the role of agriculture in the problem and the solutions

Rapid growth of antimicrobial resistance: the role of agriculture in the problem and the solutions

Anti-Biofilm and Antimicrobial Activities of Five Edible and Medicinal Macrofungi Samples on Some Biofilm Producing Multi Drug Resistant Enterococcus Strains

Antibiotic-loaded MoS₂nanosheets to combat bacterial resistance via biofilm inhibition

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Development of Resistance to Antibiotics

Cited by 4 publications

References 31 publications

Rapid growth of antimicrobial resistance: the role of agriculture in the problem and the solutions

Rapid growth of antimicrobial resistance: the role of agriculture in the problem and the solutions

Anti-Biofilm and Antimicrobial Activities of Five Edible and Medicinal Macrofungi Samples on Some Biofilm Producing Multi Drug Resistant Enterococcus Strains

Antibiotic-loaded MoS2nanosheets to combat bacterial resistance via biofilm inhibition

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Antibiotic-loaded MoS₂nanosheets to combat bacterial resistance via biofilm inhibition