Development of rhabdomyolysis in a child after norovirus gastroenteritis

Nishio, Tomohiro; Yonetani, Ryoko; Ito, Eisuke; Yoneta, Makiko; Maruo, Yoshihiro; Yoshida, Tokiko; Sugimoto, Tohru

doi:10.1186/s12887-016-0720-9

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…In the U.S., they are responsible for approximately 20 million infections that cost the national economy $2.8 billion in health care costs and missed worker productivity [ 2 ]. In developing countries, HNoVs are estimated to cause 200,000 deaths in children under 5 years of age and are also increasingly associated with devastating infections in immunocompromised hosts [ 3 , 4 , 5 , 6 ]. Despite this large disease burden, relatively little is known about the pathogenesis of this virus.…”

Section: Introductionmentioning

confidence: 99%

Attach Me If You Can: Murine Norovirus Binds to Commensal Bacteria and Fungi

Madrigal

Bhar

Hackett

et al. 2020

Viruses

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The presence of commensal bacteria enhances both acute and persistent infection of murine noroviruses. For several enteric viral pathogens, mechanisms by which these bacteria enhance infection involve direct interactions between the virus and bacteria. While it has been demonstrated that human noroviruses bind to a variety of commensal bacteria, it is not known if this is also true for murine noroviruses. The goal of this study was to characterize interactions between murine noroviruses and commensal bacteria and determine the impact of bacterial growth conditions, incubation temperature and time, on murine norovirus attachment to microbes that comprise the mammalian microbiome. We show that murine noroviruses bind directly to commensal bacteria and show similar patterns of attachment as human norovirus VLPs examined under the same conditions. Furthermore, while binding levels are not impacted by the growth phase of the bacteria, they do change with time and incubation temperature. We also found that murine norovirus can bind to a commensal fungal species, Candida albicans.

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Section: Introductionmentioning

confidence: 99%

Attach Me If You Can: Murine Norovirus Binds to Commensal Bacteria and Fungi

Madrigal

Bhar

Hackett

et al. 2020

Viruses

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“…Influenza A and B, enteroviruses, and human immunodeficiency virus have been most implicated in precipitating rhabdomyolysis. Less commonly, it can be triggered by herpesviruses, Chinkungunya, and norovirus 8,9,10,11,12 . Infection with another coronavirus, SARS-CoV-1, has also been associated with rhabdomyolysis, during the 2002-2004 outbreak, but few cases were reported in the literature 13 .…”

Section: Hospital Coursementioning

confidence: 99%

Rhabdomyolysis as the Initial Presentation of SARS-CoV-2 in an Adolescent

et al. 2021

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The novel coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has created a global pandemic, with many cases affecting the elderly. However, children have been affected as well, with about 2.4-3.7% of cases reported. This case is the first published case of an adolescent presenting with rhabdomyolysis as the first sign of COVID-19, with extremely elevated creatinine kinase (CK) levels, approaching almost 400,000 U/L. This case adds to the growing body of literature of a variety of life-threatening manifestations associated with SARS-CoV-2 infection, and highlights the importance of how prompt recognition of these unique presentations of the disease is important to mitigate complications.

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Molecular Epidemiology of Norovirus (NoV) Infection in Mie Prefecture: The Kinetics of Norovirus Antigenemia in Pediatric Patients

Negoro

Kuurdor

Lartey

et al. 2022

Viruses

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Few studies have shown the presence of norovirus (NoV) RNA in blood circulation but there is no data on norovirus antigenemia. We examined both antigenemia and RNAemia from the sera of children with NoV infections and studied whether norovirus antigenemia is correlated with the levels of norovirus-specific antibodies and clinical severity of gastroenteritis. Both stool and serum samples were collected from 63 children admitted to Mie National Hospital with acute NoV gastroenteritis. Norovirus antigen and RNA were detected in sera by ELISA and real-time RT-PCR, respectively. NoV antigenemia was found in 54.8% (34/62) and RNAemia in 14.3% (9/63) of sera samples. Antigenemia was more common in the younger age group (0–2 years) than in the older age groups, and most patients were male. There was no correlation between stool viral load and norovirus antigen (NoV-Ag) levels (rs = −0.063; Cl −0.3150 to 0.1967; p = 0.6251). Higher levels of acute norovirus-specific IgG serum antibodies resulted in a lower antigenemia OD value (n = 61; r = −0.4258; CI −0.62 to −0.19; p = 0.0006). Norovirus antigenemia occurred more commonly in children under 2 years of age with NoV-associated acute gastroenteritis. The occurrence of antigenemia was not correlated with stool viral load or disease severity.

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Development of rhabdomyolysis in a child after norovirus gastroenteritis

Cited by 3 publications

References 10 publications

Attach Me If You Can: Murine Norovirus Binds to Commensal Bacteria and Fungi

Attach Me If You Can: Murine Norovirus Binds to Commensal Bacteria and Fungi

Rhabdomyolysis as the Initial Presentation of SARS-CoV-2 in an Adolescent

Molecular Epidemiology of Norovirus (NoV) Infection in Mie Prefecture: The Kinetics of Norovirus Antigenemia in Pediatric Patients

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