Development of RP-HPLC method for the estimation of Rasagiline mesylate in bulk and tablet dosage forms

Abstract

A simple RP-HPLC method for the determination of Rasagiline Mesylate in bulk and tablet dosage form was developed. Numerous HPLC conditions were tested for determination of rasagiline. The best result was achieved by using Purosphere star RP-18, (150×4.6mm), 5µm column and a mobile phase consisting of Potassium Orthophosphate: Acetonitrile (60:40 v/v) adjusted to pH 7.0(±0.05) with Ammonia solution, a flow rate of 1.5 ml/min with ultraviolet detection at 210nm. The correlation coefficients for calibration curves within the detection range of 5-30µg/ml were 0.9993. The within and between-day precision was determined for both retention time and peak area. The retention time of rasagiline is 6.0 minutes.DOI: http://dx.doi.org/10.3329/icpj.v1i9.11620 International Current Pharmaceutical Journal 2012, 1(9): 285-287

Cu(ii)-thiophene-2,5-bis(amino-alcohol) mediated asymmetric Aldol reaction and Domino Knoevenagel Michael cyclization: a new highly efficient Lewis acid catalyst

“…[1][2][3][4][5] Among them, the asymmetric Aldol reaction and Domino Knoevenagel Michael cyclization reaction are the most powerful and efficient approaches for accessing various enantiomerically enriched biomolecules. 6,7 The core framework '3-alkyl-3-hydroxyindolin-2-ones' is present in a large number of natural products [8][9][10][11][12][13][14] and drug molecules [15][16][17][18][19] such as maremycins, 17 arundaphine, 20 donaxaridine, 21 paratunamide, 22 , (R)-convolutamydines A, B and E, [23][24][25][26][27] ustraminol, 28 diazonamides, [29][30][31][32][33] leptosin D, 34 3 0 -hydroxyglucoisatisin, 35 CPC-1, 36 3-hydroxy welwitindolinones C, 37 TMC-95 (A-D), [38][39][40] celogentin K, 41 dioxibrassinin 42 (Fig. 1).…”

Fluorescence of isatin N‐phenylsemicarbazones: aggregation and hydrazide–hydrazonol tautomerism

“…Despite the low fluorescence intensity of isatin N ‐phenylsemicarbazone derivatives due to the predominant non‐radiative excited state deactivation, results of this study can be a useful supplement for better understanding of complex processes in solution of effective colorimetric sensors based on isatin N ‐phenylsemicarbazone. Moreover, because isatin semicarbazones are often biologically active, concept of associate/hydrazide/hydrazonol equilibrium in solution can help other researches in this field to deeply understand the structure–property and structure–biological activity relationships of some isatin semicarbazones. Structure of studied isatin N ‐phenylsemicarbazone E ‐isomers is depicted in Scheme .…”

(R*)-1-Benzyl-3-(2-hydroxyphenyl)indoline-2-one

“…It exhibits endogamous activity in mammals (Chaudhary et al, 2013) and has shown cardioinhibitory effects on a frog's heart, and hypotensive, respiratory depression and antidiuretic effects (Pandeya et al, 2005). Isatin also possess anticancer (Khan et al, 2015), antioxidant (Sammaiah & Pragathi, 2014), antiviral (Gomathi et al, 2013), antimicrobial (Saxena et al, 2015), analgesic (Pal et al,201), anti-inflammatory (Hajare & Chinchole, 2013), antitubercular (Aboul-fadl & BinJubair, 2010), anticonvulsant (Raj, 2012) and antianxiety (Grewal, 2014) activities.…”