Development of scalable and versatile nanomaterial libraries for nanosafety studies: polyvinylpyrrolidone (PVP) capped metal oxide nanoparticles

Briffa, Sophie Marie; Lynch, Iseult; Trouillet, Vanessa; Bruns, Michael; Hapiuk, Dimitri; Liu, J.; Palmer, Richard E.; Valsami-Jones, Eugénia

doi:10.1039/c6ra25064e

Cited by 23 publications

(21 citation statements)

References 59 publications

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“…Cerium nitrate hexahydrate, zinc nitrate hexahydrate, acetone, and 10k PVP were all used as received from suppliers. 10k PVP capped CeO 2 and ZnO were synthesised according to Briffa et al 11 Details of the characterisation of the pristine NPs (dynamic light scattering (DLS), zeta potential, ultraviolet visible light spectroscopy (UV-VIS), X-ray photoelectron spectroscopy (XPS), Fourier transform infra-red (FT-IR) and transmission electron microscopy (TEM)) are reported in the same paper. 11 Characterisation at time 0 and 24 hours has also been conducted in HH Combo medium (Table S.5 for CeO 2 and Table S.6 † for ZnO NPs).…”

Section: Np Synthesis and Characterisationmentioning

confidence: 99%

“…10k PVP capped CeO 2 and ZnO were synthesised according to Briffa et al 11 Details of the characterisation of the pristine NPs (dynamic light scattering (DLS), zeta potential, ultraviolet visible light spectroscopy (UV-VIS), X-ray photoelectron spectroscopy (XPS), Fourier transform infra-red (FT-IR) and transmission electron microscopy (TEM)) are reported in the same paper. 11 Characterisation at time 0 and 24 hours has also been conducted in HH Combo medium (Table S.5 for CeO 2 and Table S.6 † for ZnO NPs). The fresh NP pellet resulting from the synthesis, following an acetone wash to remove excess PVP, having a concentration of 2.030 ± 0.480 mg L −1 for CeO 2 and 0.960 ± 0.137 mg L −1 for ZnO as determined by ICP-OES, was retained.…”

Section: Np Synthesis and Characterisationmentioning

confidence: 99%

“…For this reason the development of NP libraries is critical, in order to be able to systematically vary NP properties and hence test and isolate the toxicological effects of a single variable. 11 Over and above NP properties, there are several environmental factors that need to be considered also. 12 For instance, NP surfaces have a high adsorption capacity leading to binding of natural organic matter (NOM) or organismsecreted biomolecules, which changes the NP surface properties and interactions.…”

Section: Introductionmentioning

confidence: 99%

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Uptake and impacts of polyvinylpyrrolidone (PVP) capped metal oxide nanoparticles on Daphnia magna: role of core composition and acquired corona

Briffa

Nasser

Valsami-Jones

et al. 2018

Environ. Sci.: Nano

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Section: Np Synthesis and Characterisationmentioning

confidence: 99%

Section: Np Synthesis and Characterisationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Uptake and impacts of polyvinylpyrrolidone (PVP) capped metal oxide nanoparticles on Daphnia magna: role of core composition and acquired corona

Briffa

Nasser

Valsami-Jones

et al. 2018

Environ. Sci.: Nano

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“…The 4 week duration was chosen since it is a longer time period than that currently presented in the literature and a sufficiently long period to determine the influence of temperature, given that the PVP capped metal oxide NMs were found to be stable at room temperature, when measured by DLS, for a minimum of six months. 14 The temperature ageing study was carried out at 25, 45, 65 and 80°C. The first temperature is often used as the reference room temperature and the final one is lower than the boiling point of water to avoid the physical impact of boiling.…”

Section: Methodsmentioning

confidence: 99%

“…14,26,27 In the case of the zinc oxide, two peaks were found at 250 nm and just below 300 nm, which were representative of PVP and zinc oxide, respectively. Since a similar behaviour to that seen for the PVP capped ceria NMs is observed, this suggests that the PVP capping in fact becomes less effective with elevated temperature.…”

Section: Uv-vis Uv-vis Analysis Revealed Information About Both the mentioning

confidence: 99%

Thermal transformations of manufactured nanomaterials as a proposed proxy for ageing

Briffa

Lynch

Trouillet

et al. 2018

Environ. Sci.: Nano

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aAgeing is an important part of a manufactured nanomaterial's life cycle and can be considered as a transformation over time. It is particularly relevant to nanomaterials (NMs) because they are more reactive than their bulk counterparts and therefore are likely to undergo more significant or faster transformations with time. The conditions upon exposure of a NM to the environment, e.g. temperature, humidity and redox, will all individually affect ageing, as well as time. In experimental simulations, time has to be substituted by a proxy that makes timescales more realistic. Thermal ageing accelerates the normal ageing processes of NMs and thus elevated temperatures can be used to simulate prolonged ageing, allowing access to information on the long-term effects of NM ageing within a shorter time. Similar approaches are utilised in experimental simulation of protein fibrillation, for example, where processes that naturally occur over decades are accelerated to days or hours. In this work, time and temperature dependent studies were carried out on a fully characterised library of laboratory synthesised comparable polyvinylpyrrolidone (PVP) capped NMs (with core compositions of ceria, copper oxide and zinc oxide) and a commercially available uncoated cerium dioxide NM, to assess their transformations. Specifically, physical and chemical changes were studied on NMs exposed to various temperatures (25, 45, 65 and 80°C) for a period of 4 weeks. The size, zeta potential, agglomeration/aggregation and valence state of the NMs were studied through dynamic light scattering (DLS), zeta potential, ultra-violet visible light spectroscopy (UV-VIS), transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS), as a function of time. Results generally show a decrease in NM stability with increasing temperature and time. Changes in the NM size and core oxidation state were noted with increasing temperature/time. These changes varied depending on the NM core composition. Additionally the PVP capping, despite stabilising the NM dispersion, still allowed the NM core to be influenced by external factors, thus indicating likely ageing-related reduction in efficiency, though to a lesser extent than the uncapped particles. Overall the experiments recorded a complex picture of transformations as a function of time/temperature highlighting the complexity of NMs' ageing.

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Forcespun polyvinylpyrrolidone/copper and polyethylene oxide/copper composite fibers and their use as antibacterial agents

Hasan

Gonzalez

Munoz

et al. 2021

J of Applied Polymer Sci

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Copper nanoparticles (CuNPs) embedded in polyvinylpyrrolidone (PVP) and polyethylene oxide (PEO) fiber-matrices were prepared through centrifugal spinning of PVP/ethanol and PEO/aqueous solutions, respectively. The prime focus of the current study is to investigate the antibacterial activity of composite fibers against Escherichia coli (E. coli) and Bacillus cereus (B. cereus) bacteria. During the fiber formation, the centrifugal spinning parameters such as spinneret rotational speed, spinneret to collector distance, and relative humidity were carefully chosen to obtain long and continuous fibers. The structural and morphological analyses of both composite fibers were investigated using scanning electron microscopy, X-ray diffraction, energy-dispersive X-ray spectroscopy, and thermogravimetric analysis. In the antibacterial test, PVP/Cu and PEO/Cu composite fibrous membranes exhibited inhibition efficiency of 99.98% and 99.99% against E. coli and B. cereus bacteria, respectively. Basically, CuNPs were well embedded in the fibrous membrane at the nanoscale level, which facilitated the inhibition of bacterial functions through the inactivation of the chemical structure of the cells. Such an effective antibacterial agent obtained from forcespun composite fibers could be promising candidates for biomedical applications.

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Development of scalable and versatile nanomaterial libraries for nanosafety studies: polyvinylpyrrolidone (PVP) capped metal oxide nanoparticles

Abstract: A simple synthesis protocol produced a library of PVP-capped metal oxide nanomaterials with systematically varied properties for hypothesis-driven nano(eco)toxicological studies.

Cited by 23 publications

References 59 publications

Uptake and impacts of polyvinylpyrrolidone (PVP) capped metal oxide nanoparticles on Daphnia magna: role of core composition and acquired corona

Uptake and impacts of polyvinylpyrrolidone (PVP) capped metal oxide nanoparticles on Daphnia magna: role of core composition and acquired corona

Thermal transformations of manufactured nanomaterials as a proposed proxy for ageing

Forcespun polyvinylpyrrolidone/copper and polyethylene oxide/copper composite fibers and their use as antibacterial agents

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