2024
DOI: 10.1007/s00044-024-03227-x
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Development of semisynthetic saponin immunostimulants

Di Bai,
Hyunjung Kim,
Pengfei Wang

Abstract: Many natural saponins demonstrate immunostimulatory adjuvant activities, but they also have some inherent drawbacks that limit their clinical use. To overcome these limitations, extensive structure-activity-relationship (SAR) studies have been conducted. The SAR studies of QS-21 and related saponins reveal that their respective fatty side chains are crucial for potentiating a strong cellular immune response. Replacing the hydrolytically unstable ester side chain in the C28 oligosaccharide domain with an amide … Show more

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