Development of sensitive amperometric hydrogen peroxide sensor using a CuNPs/MB/MWCNT-C60-Cs-IL nanocomposite modified glassy carbon electrode

Roushani, Mahmoud; Bakyas, Kobra; Dizajdizi, Behruz Zare

doi:10.1016/j.msec.2016.03.078

Cited by 28 publications

(8 citation statements)

References 33 publications

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“…The ratiometric sensor based on MXene exhibited great electrocatalytic capability toward the model analytepiroxicamwith significantly enhanced repeatibility and stability in comparison with a nonratio sensor. To further improve its sensing performance, the platform was modified by integrating with copper nanoparticles (CuNPs). , In this composite system, MXene acted as a signal-enhancing matrix to adsorb inner reference substance (MB) and anchor CuNPs, and the synergistic effect of the three elements affords the designed platform favorable sensitivity, stability, reproducibility, robustness, and reliability. Finally, the sensor was applied to analyze piroxicam in tablet and human serum samples with satisfactory recoveries.…”

mentioning

confidence: 99%

“…To further improve its sensing performance, the platform was modified by integrating with copper nanoparticles (CuNPs). 21,22 In this composite system, MXene acted as a signal-enhancing matrix to adsorb inner reference substance (MB) and anchor CuNPs, and the synergistic effect of the three elements affords the designed platform favorable sensitivity, stability, reproduci- Instruments. Electrochemical measurements were performed on a CHI 660E Electrochemical Workstation (ChenHua Instruments Co., Shanghai, China) with a classical three-electrode system that consists of bare or modified glassy carbon electrode (GCE, 4 mm), platinum wire, and saturated calomel electrode.…”

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confidence: 99%

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MXene with Great Adsorption Ability toward Organic Dye: An Excellent Material for Constructing a Ratiometric Electrochemical Sensing Platform

2019

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Ratiometric electrochemical sensors coupled with an intrinsic built-in correction have received much attention in biochemical analysis, which can effectively avoid potential impacts from both intrinsic and extrinsic factors. However, the complex modification procedure and the unstable reference signal limit development and application of ratiometric sensing. To address these issues, we proposed a novel ratiometric electrochemical platform based on MXene. Introduction of built-in correction was realized via simple one-step incubation of MXene in solution containing the reference molecule methylene blue (MB), and their firm electrostatic interaction ensures the strong adsorption capability of MXene toward MB. Remarkable enhancement in repeatibility and stability compared with nonratio sensor was proved by detecting the model analyte piroxicam. Furthermore, compatibility of the ratio sensor was demonstrated by integrating copper nanoparticles (CuNPs) into the platform. It turned out that sensing performance of the hybrid electrochemical sensor was significantly improved owing to synergistic effect of MXene and CuNPs, where the former affords a large specific surface area as well as quick electron transport, and the latter possess decent electrical catalytic ability. In all, the proposed ratiometric sensor based on MXene features easy preparation, superb reproducibility, robustness, and broad applicability, affording the platform highly competitive and reliable in the determination of a wide range of substances.

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confidence: 99%

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confidence: 99%

MXene with Great Adsorption Ability toward Organic Dye: An Excellent Material for Constructing a Ratiometric Electrochemical Sensing Platform

2019

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“…Here, the electro-deposition of AuNPs onto MB film can greatly enlarge the electrode surface for CP immobilization, and accordingly improve the sensitivity of the sensor. The detection limit of our “on-off-on” detection platform for H 2 O 2 detection was lower than other AuNPs 49 50 51 52 53 or MB 54 55 56 57 based electrochemical methods, which can satisfy the demand for H 2 O 2 detection in real samples such as food or industrial products. Thus, our proposed sensor could be used to quantify H 2 O 2 for food safety and clinical diagnosis.…”

Section: Resultsmentioning

confidence: 92%

Application of iridium(III) complex in label-free and non-enzymatic electrochemical detection of hydrogen peroxide based on a novel “on-off-on” switch platform

Miao

Yang

Leung

et al. 2016

Sci Rep

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We herein report a label-free and non-enzymatic electrochemical sensor for the highly sensitive detection of hydrogen peroxide (H2O2) based on a novel “on-off-on” switch system. In our design, MB was used as an electron mediator to accelerate the electron transfer while AuNPs was used to amplify the electrochemical signal due to its excellent biocompatibility and good conductivity. The “switch-off” state was achieved by introducing the guanine-rich capture probe (CP) and an iridium complex onto the electrode surface to form a hydrophobic layer, which then hinders electron transfer. Upon addition of H2O2, fenton reaction occurs and produces OH• in the presence of Fe2+. The OH• cleaves the CP into DNA fragments, thus resulting in the release of CP and iridium complex from the sensing interface, recovering the electrochemical signal to generate a “switch-on” state. Based on this novel switch system, a detection limit as low as 3.2 pM can be achieved for H2O2 detection. Moreover, satisfactory results were obtained by using this method for the detection of H2O2 in sterilized milk. To the best of our knowledge, this is the first G-quadruplex-based electrochemical sensor using an iridium(III) complex.

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“…Various analytical techniques such as titrimetry , spectrophotometry , Fluorometry , fluorescence , chemiluminecence and electrochemical methods , were used for determination of H 2 O 2 . Among these methods, electrochemical assays have attracted great attention because of their high sensitivity, simplicity, low detection limit, fast response time, ease of operation, low cost and high accuracy . Determination of H 2 O 2 at the bare electrode is not suitable for analytical application due to the slow electron transfer reaction, high overpotential, low sensitivity and reproducibility.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Electrochemical Hydrogen Peroxide Sensor Based on Iron Oxide‐Reduced Graphene Oxide‐Chitosan Modified with DNA‐Celestine Blue

et al. 2017

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The present study describes a novel and very sensitive electrochemical assay for determination of hydrogen peroxide (H2O2) based on synergistic effects of reduced graphene oxide‐ magnetic iron oxide nanocomposite (rGO‐Fe3O4) and celestine blue (CB) for electrochemical reduction of H2O2. rGO‐Fe3O4 nanocomposite was synthesized and characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X‐ray diffraction (XRD), electrochemical impedance spectroscopy and cyclic voltammetry. Chitosan (Chit) was used for immobilization of amino‐terminated single‐stranded DNA (ss‐DNA) molecules via a glutaraldehyde (GA) to the surface of rGO‐Fe3O4. The MTT (3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) results confirmed the biocompatibility of nanocomposite. Experimental parameters affecting the ss‐DNA molecules immobilization were optimized. Finally, by accumulation of the CB on the surface of the rGO‐Fe3O4‐Chit/ssDNA, very sensitive amperometric H2O2 sensor was fabricated. The electrocatalytic activity of the rGO‐Fe3O4‐Chit/DNA‐CB electrode toward H2O2 reduction was found to be very efficient, yielding very low detection limit (DL) of 42 nM and a sensitivity of 8.51 μA/μM. Result shows that complex matrices of the human serum samples did not interfere with the fabricated sensor. The developed sensor provided significant advantages in terms of low detection limit, high stability and good reproducibility for detection of H2O2 in comparison with recently reported electrochemical H2O2 sensors.

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Development of sensitive amperometric hydrogen peroxide sensor using a CuNPs/MB/MWCNT-C60-Cs-IL nanocomposite modified glassy carbon electrode

Cited by 28 publications

References 33 publications

MXene with Great Adsorption Ability toward Organic Dye: An Excellent Material for Constructing a Ratiometric Electrochemical Sensing Platform

MXene with Great Adsorption Ability toward Organic Dye: An Excellent Material for Constructing a Ratiometric Electrochemical Sensing Platform

Application of iridium(III) complex in label-free and non-enzymatic electrochemical detection of hydrogen peroxide based on a novel “on-off-on” switch platform

Highly Sensitive Electrochemical Hydrogen Peroxide Sensor Based on Iron Oxide‐Reduced Graphene Oxide‐Chitosan Modified with DNA‐Celestine Blue

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