Development of sensitive impedimetric urea biosensor using DC sputtered Nano-ZnO on TiO2 thin film as a novel hierarchical nanostructure transducer

Rahmanian, Reza; Mozaffari, M.; Amoli, Hossein Salar; Abedi, Mohammad Reza

doi:10.1016/j.snb.2017.10.009

Cited by 60 publications

(16 citation statements)

References 83 publications

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“…The increase in urea concentration in pathological human fluids as blood (normal range is 15-40 mg/dL) and urine causes urinary tract obstruction, dehydration and renal failure. In contrast, the low urea levels may be related to hepatic failure, cachexia and nephritic syndrome [55]. A potentiometric urea biosensor was developed by Chen et al using an electrochemical cell with a saturated calomel electrode, and a nanoporous TiO 2 film electrode with immobilized urease as RE and WE, respectively [31].…”

Section: Potentiometricmentioning

confidence: 99%

Nanostructured Titanium Dioxide Surfaces for Electrochemical Biosensing

Bertel

Miranda

García-Martín

2021

Sensors

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TiO2 electrochemical biosensors represent an option for biomolecules recognition associated with diseases, food or environmental contaminants, drug interactions and related topics. The relevance of TiO2 biosensors is due to the high selectivity and sensitivity that can be achieved. The development of electrochemical biosensors based on nanostructured TiO2 surfaces requires knowing the signal extracted from them and its relationship with the properties of the transducer, such as the crystalline phase, the roughness and the morphology of the TiO2 nanostructures. Using relevant literature published in the last decade, an overview of TiO2 based biosensors is here provided. First, the principal fabrication methods of nanostructured TiO2 surfaces are presented and their properties are briefly described. Secondly, the different detection techniques and representative examples of their applications are provided. Finally, the functionalization strategies with biomolecules are discussed. This work could contribute as a reference for the design of electrochemical biosensors based on nanostructured TiO2 surfaces, considering the detection technique and the experimental electrochemical conditions needed for a specific analyte.

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Section: Potentiometricmentioning

confidence: 99%

Nanostructured Titanium Dioxide Surfaces for Electrochemical Biosensing

Bertel

Miranda

García-Martín

2021

Sensors

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“…self-assembly [144] Nanochannels Silicon (Si) and glass [210], polyethylene terephthalate (PET) and polydimethylsiloxane (PDMS) [211,212] Chemical etching [211], nanoreplica molding [162], photolithography [210,212], soft lithography [212], microflow patterning [212] 3D Complex 3D structures Gold (Au) [213], Silver (Ag) [214], Platinum (Pt), [213], metal oxides: zinc oxide (ZnO), copper (Cu) and copper oxide (CuO), titanium(IV) oxide (TiO 2 ) [215][216][217], Carbon fiber(CF) [216], reduced GO (rGO) [216,218], cobalt phosphate (Co 2 (PO 2 ) 2 ) [219,220], polydimethylsiloxane (PDMS) [221,222] Sputtering [215], electrodeposition [216], nanoparticle nucleation [219], hydrothermal synthesis [161], seedless one-spot synthesis [214], self-assembly [216] electrochemical activation [216], soft lithography [221,222] The functionalization of NPs onto a sensor platform is commonly employed in LSPR biosensors, as well as in SERS biosensors, to increase target-binding capacity. [39,53,172,[263][264][265] Nanolattices are a common type of nanoarray structure, which is formed when the NPs are arranged in an ordered array which enables them to scatter light and produce diffracted waves.…”

Section: Nanoparticlesmentioning

confidence: 99%

Advances in Biosensors and Diagnostic Technologies Using Nanostructures and Nanomaterials

Welch

Powell

Clevinger

et al. 2021

Adv Funct Materials

115

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Nanoscale materials have unique properties that make them especially useful for biomedical diagnostic applications. Recent developments in nanoengineering have resulted in increasing use of nanostructures in biosensors. Various types of 0D, 1D, 2D, and 3D nanostructures have been used to improve biosensor sensitivity, selectivity, limit of detection, and time to result, among other metrics. These nanostructures have been integrated into electrochemical, optical, and other biosensors for this purpose. Here, the most recent advances in the use of nanostructured materials in biosensors are described. This includes a discussion of nanoparticles, nanorods, nanofibers, nanopillars, nanowires, nanosheets, indented nanopatterns (nanoholes and nanoslits), nanogaps, nanochannels, nanopores, nanofunctionalized surfaces, and complex hierarchical structures and their unique advantages and applications in biosensors. Clinical applications of these nanobiosensors are also highlighted along with a discussion of the future directions for these materials in diagnostics.

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“…REA is the final product during the metabolism of protein in the human body, and its level ranges from 2.5 to 7.5 mM [1]. Abnormal changes in urea level may indicate diseases in the kidney or liver, such as kidney failure or liver failure, etc [2]. There are many techniques for the determination of urea, such as colorimetry [3], fluorimetry [4], spectrophotometry [5], HPLC [6], chemiluminometric [7], etc.…”

Section: Introductionmentioning

confidence: 99%