Development of SERS tags for human diseases screening and detection

Gong, Tianxun; Das, Chandreyee Manas; Yin, Ming‐Jie; Lv, Tian-Run; Singh, Nishtha Manish; Soehartono, Alana Mauluidy; Singh, Gurvinder; An, Quan‐Fu; Yong, Ken‐Tye

doi:10.1016/j.ccr.2022.214711

Cited by 46 publications

(18 citation statements)

References 318 publications

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“…Organic or dye molecules can be attached to the surface of plasmonic nanoparticles that act as SERS tags. Using multiple SERS tags in a probe can lead to efficient multiplexed detection of biological species with low detection limits, high sensitivity, selectivity, and photostability 119 , 120 . Molecules can be combined with SERS tags to form an immunocomplex whose structure disintegrates and releases Raman probes, causing signal alterations 121 .…”

Section: Raman Probes For Theranosticsmentioning

confidence: 99%

“…The usage of Raman tags using Raman reporter often has some intrinsic disadvantages which affect their biocompatibility, involve high cost, offer limited variety, and are often difficult to tag 149 . The stability of the tags in physiological conditions is also an issue and might affect the reliability of the data analysis 119 , 120 . Therefore, for both Raman and SERS, there is an option to employ the label-free modality, which does not involve the use of any exogenous fluorophores.…”

Section: Mitigating the Challenges Of The Use Of Raman And Sers In Th...mentioning

confidence: 99%

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Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

Singh¹,

Yadav²,

Dhillon³

et al. 2023

Nanotheranostics

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Although medical advances have increased our grasp of the amazing morphological, genetic, and phenotypic diversity of diseases, there are still significant technological barriers to understanding their complex and dynamic character. Specifically, the complexities of the biological systems throw a diverse set of challenges in developing efficient theranostic tools and methodologies that can probe and treat pathologies. Among several emerging theranostic techniques such as photodynamic therapy, photothermal therapy, magnetic resonance imaging, and computed tomography, Raman spectroscopy (RS) is emerging as a promising tool that is a label-free, cost-effective, and non-destructive technique. It can also provide real-time diagnostic information and can employ multimodal probes for detection and therapy. These attributes make it a perfect candidate for the analytical counterpart of the existing theranostic probes. The use of biocompatible nanomaterials for the fabrication of Raman probes provides rich structural information about the biological molecules, cells, and tissues and highly sensitive information down to single-molecule levels when integrated with advanced RS tools. This review discusses the fundamentals of Raman spectroscopic tools such as surface-enhanced Raman spectroscopy and Resonance Raman spectroscopy, their variants, and the associated theranostic applications. Besides the advantages, the current limitations, and future challenges of using RS in disease diagnosis and therapy have also been discussed.

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Section: Raman Probes For Theranosticsmentioning

confidence: 99%

Section: Mitigating the Challenges Of The Use Of Raman And Sers In Th...mentioning

confidence: 99%

Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

Singh¹,

Yadav²,

Dhillon³

et al. 2023

Nanotheranostics

View full text Add to dashboard Cite

show abstract

“…With the sustainable demands on improving living quality to reach intelligent life, the central role of sensors becomes more and more conspicuous in the fields of environmental evaluation, food production, health monitoring, and bionics. [67,127] Thus, researchers are dedicated to exploiting the sensors with high sensitivity, fast response, and appropriate detection range. Conductive polymers can directly transmit electrical signals, which are naturally prominent candidates for the construction of advanced sensors.…”

Section: Sensorsmentioning

confidence: 99%

Micro/Nano‐Fabrication of Flexible Poly(3,4‐Ethylenedioxythiophene)‐Based Conductive Films for High‐Performance Microdevices

Zhang

Yang

et al. 2023

Small

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With the increasing demands for novel flexible organic electronic devices, conductive polymers are now becoming the rising star for reaching such targets, which has witnessed significant breakthroughs in the fields of thermoelectric devices, solar cells, sensors, and hydrogels during the past decade due to their outstanding conductivity, solution‐processing ability, as well as tailorability. However, the commercialization of those devices still lags markedly behind the corresponding research advances, arising from the not high enough performance and limited manufacturing techniques. The conductivity and micro/nano‐structure of conductive polymer films are two critical factors for achieving high‐performance microdevices. In this review, the state‐of‐the‐art technologies for developing organic devices by using conductive polymers are comprehensively summarized, which will begin with a description of the commonly used synthesis methods and mechanisms for conductive polymers. Next, the current techniques for the fabrication of conductive polymer films will be proffered and discussed. Subsequently, approaches for tailoring the nanostructures and microstructures of conductive polymer films are summarized and discussed. Then, the applications of micro/nano‐fabricated conductive films‐based devices in various fields are given and the role of the micro/nano‐structures on the device performances is highlighted. Finally, the perspectives on future directions in this exciting field are presented.

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“…[10,11,16] As the core component of SERS tags, SERS reporter molecules have been developed continuously from classical dye molecules with large cross sections to thiolated molecules easily bound to precious metal substrates, and alkynes without biological background interference. [17] For instance, Li et al used several thiobenzoic acid analogues as SERS reporters owing to their ability to easily bind to precious metal substrates, which solves the problem of poor signal stability caused by weak interactions between dyes and metal substrates. [18] The background interference for in vivo monitoring and imaging could be avoided by utilizing trifunctional polyene-based SERS reporters because of the inconsistency between the SERS band of alkyne molecules and SERS scattering of all internal molecules observed in vivo.…”

Section: Introductionmentioning

confidence: 99%

Recent Research Progress of Surface‐Enhanced Raman Scattering Dominated Analysis Strategies in Early Diagnosis of Diseases

Chen

Zheng

Tang

et al. 2023

Chemistry An Asian Journal

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Timely and powerful diagnostic means can achieve better therapeutic effects, reduce disease torment, and improve survival rate. As a powerful non‐invasive spectroscopy technology, surface‐enhanced Raman scattering (SERS) have testified to be a great potential candidate for extensive early clinical disease diagnosis. In recent years, the introduction of SERS label, combined with other analysis modes or artificial intelligence, and the emergence of miniaturized devices have made SERS technology more advantageous in early diagnosis of diseases. This review focuses on the research progress of SERS dominated analytical strategies in the field of early disease diagnosis in the past five years. The main content includes the application of label‐free SERS detection; the construction of label SERS methodologies for various disease markers; SERS dominated multimode early disease diagnosis strategies; integration of SERS and artificial intelligence; portable Raman equipment and SERS imaging; and opportunities and trends for SERS diagnostic technology in the future.

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Development of SERS tags for human diseases screening and detection

Cited by 46 publications

References 318 publications

Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

Emergence of Raman Spectroscopy as a Probing Tool for Theranostics

Micro/Nano‐Fabrication of Flexible Poly(3,4‐Ethylenedioxythiophene)‐Based Conductive Films for High‐Performance Microdevices

Recent Research Progress of Surface‐Enhanced Raman Scattering Dominated Analysis Strategies in Early Diagnosis of Diseases

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