Development of silver nanoparticles loaded chitosan-alginate constructs with biomedical potentialities

Bilal, Muhammad; Rasheed, Tahir; Iqbal, Hafiz M.N.; Li, Chuanlong; Hu, Hongbo; Zhang, Xuehong

doi:10.1016/j.ijbiomac.2017.07.047

Cited by 110 publications

(68 citation statements)

References 33 publications

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“…On the other hand, the major limitations, yet to overcome, of natural-based biomaterials includes their tendency for calcification and eventual bio-deterioration. Among several metals, gold, silver, stainless steel, nickel-titanium alloy, and cobalt-chromium alloy are the most commonly used biomaterials (Bilal et al 2017b;Rasheed et al 2017). In spite of this wide spread usage of metals, the corrosion of metal is main disadvantage which happens due to chemical reaction with the body enzymes and acids.…”

Section: Major Limitations Of Biomaterialsmentioning

confidence: 99%

“…Research is underway, around the globe, to develop materialsbased novel constructs with antibacterial potentialities (Michl et al, 2014;Wang et al, 2014;Iqbal et al, 2015b;Lu et al, 2015). For instance, recently, Bilal et al (2017b) biosynthesized silver nanoparticles (AgNPs) and AgNPs-loaded chitosan-alginate constructs with significant antibacterial activities against six bacterial strains, i.e. Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, Morganella morganii and Haemophilus influenza (Bilal et al, 2017b).…”

Section: Antimicrobial Active Materialsmentioning

confidence: 99%

“…For instance, recently, Bilal et al (2017b) biosynthesized silver nanoparticles (AgNPs) and AgNPs-loaded chitosan-alginate constructs with significant antibacterial activities against six bacterial strains, i.e. Staphylococcus aureus, Pseudomonas aeruginosa, Klebsiella pneumoniae, Acinetobacter baumannii, Morganella morganii and Haemophilus influenza (Bilal et al, 2017b). However, excess release of silver nanoparticles inhibits osteoblasts growth and can also cause many severe side effects such as cytotoxicity (Wang et al, 2014).…”

Section: Antimicrobial Active Materialsmentioning

confidence: 99%

“…Besides MRSA, the emergence of new antimicrobial resistance (AMR) or multidrug resistance (MDR) bacterial strains is posing serious challenge to health care services (Jindal et al, 2015;Holmes et al, 2016;Bilal et al, 2017a;Bilal et al, 2017b;Bilal et al, 2017c;Rasheed et al, 2017). AMR is defined as a temporary and permanent capability of a microbial strain, and its progeny to resist and stay viable and multiply against the medication previously used to treat them.…”

Section: Introductionmentioning

confidence: 99%

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Emerging Pathogens and Bioactive Materials: In Greening the 21st Century Biomedical Sciences

Iqbal¹,

Dhama²

2018

JEBAS

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Emerging pathogens are a major threat to the biological safety of the world in the 21 st century. Owing to many reasons, the emergence and re-emergence of deadly pathogens have increased and posed a considerable challenge to human and animal health, alike. Various factors including ecological changes along with other specific risk factors related to the type and classification of the pathogen, route of transmission and host range are among the most commonly associated criterion for emerging and reemerging pathogenic environments. Owing to the lack of essential in-depth knowledge, challenges remain in this domain to tackle and combat emerging pathogens. Significant research efforts, exploitations of natural resources with potent bioactivities, and development of scientific innovations along with new degrees of integration are required to tackle this challenging threat. Aiming to resolve these issues, various methodological approaches including in -vitro, in-vivo, ex-vivo, etc. have been exploited, in the past several years. Research is underway around the globe to develop or engineer bioactive materials. Among them, biomaterials-based therapeutic constructs are of supreme interests in the current biomedical sector. The following measures, i.e. (i) principle sources of emerging pathogens, (ii) linking pathogen surveillance of wild and domestic animals, (iii) public health surveillance at the national and international level, and (iv) importantly the coverage of these surveillance issues, etc. should be taken with utmost care. This will ultimately make a significant and essential contribution to the detection and control of emerging and re-emerging pathogens.

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Section: Major Limitations Of Biomaterialsmentioning

confidence: 99%

Section: Antimicrobial Active Materialsmentioning

confidence: 99%

Section: Antimicrobial Active Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Emerging Pathogens and Bioactive Materials: In Greening the 21st Century Biomedical Sciences

Iqbal¹,

Dhama²

2018

JEBAS

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“…Many research studies have also indicated that silver nanoparticles–containing medicinal plants such as Taraxacum officinale , Convolvulus arvensis , Gardenia jasminoides , and Artemisia vulgaris have excellent biomedical properties, including antibacterial, antioxidant, and anti‐inflammatory properties. Many other studies investigated the other biochemical properties of silver nanoparticles in the in vitro and in vivo conditions . Medicinal plants used to synthesize silver nanoparticles for their antioxidant and antimicrobial properties include Thevetia peruviana , Portulaca oleracea , Melia dubia , Garcinia mangostana , Calotropis procera , Alternanthera dentate , Abutilon indicum , Vitex negundo , Premna herbacea , Nelumbo nucifera , Memecylon edule , Cymbopogan citratus , Centella asiatica , Boerhaavia diffusa , Acalypha indica , Tribulus terrestris , Pogostemon benghalensis , Ficus carica , Eclipta prostrate , Argyreia nervosa , Vitis vinifera , Pistacia atlantica , Moringa oleifera , Citrus sinensis , Aloe vera , Trachyspermum ammi , Carica papaya , Eucalyptus hybrid , Swietenia mahogany , Acorus calamus , Musa paradisiacal , Cocous nucifera , Brassica rapa , Datura metel , Psoralea corylifolia , and Coccinia indica.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis of silver nanoparticles from aqueous extract of Ziziphora clinopodioides Lam and evaluation of their bio‐activities under in vitro and in vivo conditions

Ahmeda

Zangeneh

Kalbasi

et al. 2020

Applied Organom Chemis

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The purpose of this experiment was the green synthesis of silver nanoparticles from aqueous extracts of Ziziphora clinopodioides Lam (AgNPs@Ziziphora) and assessment of their cytotoxicity, antioxidant, antibacterial, antifungal, and cutaneous wound‐healing effects. These nanoparticles were characterized using ultraviolet–visible spectroscopy (UV–Vis), X‐ray diffraction (XRD), field emission scanning electron microscopy with energy‐dispersive X‐ray spectroscopy (FESEM‐EDX), atomic force microscopy (AFM), and transmission electron microscopy (TEM). UV–Vis, TEM, and FESEM analyses indicated that the size of Ag nanoparticles (AgNPs) depended on Z. clinopodioides and AgNO3 concentrations. In vitro biological experiments indicated that AgNPs@Ziziphora has excellent antioxidant potential against DPPH, antifungal effects against Candida guilliermondii, Candida krusei, Candida glabrata, and Candida albicans, and antibacterial activities against Staphylococcus aureus, Bacillus subtilis, Streptococcus pneumonia, Salmonella typhimurium, Pseudomonas aeruginosa, and Escherichia coli O157:H7. Also, these nanoparticles did not exhibit cytotoxicity property against human umbilical vein endothelial cells (HUVECs). An in vivo biological test revealed that AgNPs@Ziziphora ointment significantly (p ≤ 0.01) increased the levels of wound contracture, blood vessels, hydroxyl proline, hexuronic acid, hexosamine, fibrocytes, fibroblasts, and fibrocyte/fibroblast ratio and significantly (p ≤ 0.01) decreased the wound area, and levels of total cells, neutrophils, and lymphocytes than other groups in rats. The results of UV–Vis, XRD, FESEM‐EDX, AFM, and TEM confirmed that the aqueous extract of Z. clinopodioides can be used to produce silver nanoparticles with significant antioxidant, antimicrobial, and cutaneous wound‐healing properties without any cytotoxicity.

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Design and Processing Aspects of Polymer and Composite Materials

Iqbal

Rasheed

Bilal

2018

Green and Sustainable Advanced Materials

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Development of silver nanoparticles loaded chitosan-alginate constructs with biomedical potentialities

Cited by 110 publications

References 33 publications

Emerging Pathogens and Bioactive Materials: In Greening the 21st Century Biomedical Sciences

Emerging Pathogens and Bioactive Materials: In Greening the 21st Century Biomedical Sciences

Green synthesis of silver nanoparticles from aqueous extract of Ziziphora clinopodioides Lam and evaluation of their bio‐activities under in vitro and in vivo conditions

Design and Processing Aspects of Polymer and Composite Materials

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