Development of simple and fast UV-method for the quantitative determination of mometasone furoate in a large number of metered doses of an aqueous nasal spray of mometasone furoate

Abstract

Fast and simple spectrophotometric method for quantitative determination of mometasone furoate in a single dose (single actuation) of its nasal spray was developed and validated. This method is based on the spectrophotometric analysis of turbid solution of a single spray in 20 mL isopropanol at 220–310 nm. We further show applicability of this method for analysis of large number of single sprays for the dosing homogeneity. It is based on a new approach to the development of spectrophotometric quantitative determination methods for drug products and possibly other objects, allowing measurements to be carried out on sufficiently turbid test solutions. The proposed approach is not a variant of the derivative spectrophotometry and can replace the methods of derivative spectrophotometry in cases where: derivative of analyte spectrum is not intense enough; derivative of the spectrum of the matrix (turbidity and remaining components of the product) is significant when compared with the derivative of the analyte.

A specific high‐performance thin‐layer chromatography method validated for estimation of mometasone furoate and olopatadine hydrochloride

“…Mometasone is official in Indian Pharmacopeia [23], British Pharmacopeia [24], United States Pharmacopoeia [25] and European Pharmacopeia [26]. From the literature review, it is observed that many analytical methods have been developed involving spectrophotometric [27][28][29][30], HPLC [31][32][33][34][35][36][37][38][39], HPTLC [40][41][42], and stability indicating method [43][44][45][46][47] for the estimation of MOM in pharmaceutical formulations. The present manuscript describes a novel, cost-effective, and quick chromatographic separation method for the simultaneous estimation of OLO and MOM in a combined dose.…”

Synchronized Quantitative Assessment of Corticosteroid and Bronchodilator in Rotacaps by HPTLC using Fractional Factorial Design

“…[6][7][8][9][10] Extensive literature survey discloses that estimation of mometasone furoate single or in admixture with other drugs using chromatographic method (HPLC, HPTLC, GC and supercritical fluid) and UV spectrophotometry. [10][11][12][13][14][15][16][17][18][19][20][21] The estimation of FRF alone and in combination (mixture) with other active drug moiety including HPLC, GC and UV spectrophotometry has stated in published paper. [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36] The advancement of planar chromatography i.e., HPTLC has been arose as a chief tool in drug investigation and simplest of all the chromatographic techniques.…”