Development of sinomenine hydrochloride-loaded polyvinylalcohol/maltose microneedle for transdermal delivery

Cao, Yingji; Tao, Yaotian; Zhou, Youjun; Gui, Shuangying

doi:10.1016/j.jddst.2016.06.007

Cited by 39 publications

(9 citation statements)

References 14 publications

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“…[64] Cao et al reported the fabrication of hybrid PVA/MT microneedles to deliver anti-inflammatory drugs. [65] The mechanical strength of PVA microneedles were significantly improved after adding MT. Once inserted into the skin, MT dissolved completely, thus generating micropores for the release of drugs from polymeric matrix.…”

Section: Microneedle Type Polymersmentioning

confidence: 95%

Biomedical Applications of Polymeric Microneedles for Transdermal Therapeutic Delivery and Diagnosis: Current Status and Future Perspectives

Liu

Luo

Xing

2020

Advanced Therapeutics

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Transdermal drug delivery is a crucial extension of drug administration routes and has been widely acknowledged as an alternative way to traditional oral administration and subcutaneous injections due to the advantages such as increased dosage efficacy, decreased systemic side effect, and improved patient compliance. The past few decades have witnessed biomedical applications of microneedles in various cutting‐edge fields. Microneedles are needles with micron‐scale length which can pierce the epidermis of the skin in a minimally invasive manner for transdermal drug delivery. Compared with inorganic and metal microneedles, polymeric microneedles have attracted more attention because of their superior biocompatibility, nontoxicity, and biodegradability. In this review, the state‐of‐art and future biomedical applications of polymeric microneedles are summarized. First of all, a brief introduction to the polymeric microneedles, including types of polymeric microneedles and methods for the fabrication is included. Then the biomedical applications of polymeric microneedles in transdermal drug delivery and diagnosis are summarized in detail. Finally, discussions on the current limitations and future perspectives of polymeric microneedles are provided.

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Section: Microneedle Type Polymersmentioning

confidence: 95%

Biomedical Applications of Polymeric Microneedles for Transdermal Therapeutic Delivery and Diagnosis: Current Status and Future Perspectives

Liu

Luo

Xing

2020

Advanced Therapeutics

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“…When MNs are partially inserted into the skin surface, they will absorb water and swell. Due to the above characteristics, based on the osmotic pressure difference or temperature difference between ISF and the MN matrix, after fully absorbing the ISF, the pores between the polymer materials are opened larger, leading to drug release [ 50 – 53 ]. It is also not negligible that the porous characteristics of hydrogel MNs make it possible to adjust the release rate of drugs through different degrees of cross-linking, which has more advantages than soluble MNs in drug delivery [ 54 – 56 ].…”

Section: The Different Types Of Mns In the Treatment Of Tumorsmentioning

confidence: 99%

Microneedle-mediated treatment for superficial tumors by combining multiple strategies

Wang

et al. 2023

Drug Deliv. and Transl. Res.

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Superficial tumors are still challenging to overcome due to the high risk and toxicity of surgery and conventional chemotherapy. Microneedles (MNs) are widely used in the treatment of superficial skin tumors (SST) due to the high penetration rate of the stratum corneum (SC), excellent biocompatibility, simple preparation process, high patient compliance, and minimal invasion. Most importantly, MNs can provide not only efficient and rarely painful delivery carriers, but also combine multi-model strategies with photothermal therapy (PTT), immunotherapy, and gene therapy for synergistic efficacy. To promote an in-depth understanding of their superiorities, this paper systematically summarized the latest application progress of MNs in the treatment of SST by delivering various types of photosensitizers, immune signal molecules, genes, and chemotherapy drugs. Just as important, the advantages, limitations, and drug release mechanisms of MNs based on different materials are introduced in the paper. In addition, the application of MN technology to clinical practice is the ultimate goal of all the work. The obstacles and possible difficulties in expanding the production of MNs and achieving clinical transformation are briefly discussed in this paper. To be anticipated, our work will provide new insights into the precise and rarely painful treatment of SST in the future. Graphical Abstract

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“…Apart from the micro molding method, drawing lithography, droplet-born air blowing, electro-drawing, and 3D printing can achieve rapid (usually within 10 min) MN preparation as these do not require the use of a mold [ 70 , 77 , 148 , 149 ]. In Figure 7 [ 150 ], the basic steps for micro molding have been illustrated.…”

Section: Polymeric Microneedle Manufacturing Techniquesmentioning

confidence: 99%

“…Figure 7. Polymeric MNs manufacturing using micro molding method, reproduced with permission from[150], Elsevier, 2016.…”

mentioning

confidence: 99%

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

Yadav

Munni²,

Campbell

et al. 2021

Pharmaceutics

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The ongoing search for biodegradable and biocompatible microneedles (MNs) that are strong enough to penetrate skin barriers, easy to prepare, and can be translated for clinical use continues. As such, this review paper is focused upon discussing the key points (e.g., choice polymeric MNs) for the translation of MNs from laboratory to clinical practice. The review reveals that polymers are most appropriately used for dissolvable and swellable MNs due to their wide range of tunable properties and that natural polymers are an ideal material choice as they structurally mimic native cellular environments. It has also been concluded that natural and synthetic polymer combinations are useful as polymers usually lack mechanical strength, stability, or other desired properties for the fabrication and insertion of MNs. This review evaluates fabrication methods and materials choice, disease and health conditions, clinical challenges, and the future of MNs in public healthcare services, focusing on literature from the last decade.

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Development of sinomenine hydrochloride-loaded polyvinylalcohol/maltose microneedle for transdermal delivery

Cited by 39 publications

References 14 publications

Biomedical Applications of Polymeric Microneedles for Transdermal Therapeutic Delivery and Diagnosis: Current Status and Future Perspectives

Biomedical Applications of Polymeric Microneedles for Transdermal Therapeutic Delivery and Diagnosis: Current Status and Future Perspectives

Microneedle-mediated treatment for superficial tumors by combining multiple strategies

Translation of Polymeric Microneedles for Treatment of Human Diseases: Recent Trends, Progress, and Challenges

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