Industrial power has a large load base and considerable adjustment potential. Enterprises with a high degree of automation and adjustable potential can automatically adjust the production status according to the peak load, frequency of the power grid and the demand of new energy consumption, so as to realize automatic demand response. This paper analyzes the opportunities and challenges of industrial demand response under the integration of Industrial Internet and Energy Internet. At the same time, the development direction of industrial demand response under the new situation, such as comprehensive demand response, adjustable load resources and other technical and policy aspects are prospected.