Factors that cause nonuniformity in the luminescence lifetime of pressure-sensitive paints (PSPs) were investigated. The lifetime imaging method of PSP does not theoretically require wind-off reference images. Therefore, it can improve measurement accuracy because it can eliminate errors caused by the deformation or movement of the model during the measurement. However, it is reported that the luminescence lifetime of PSP is not uniform on the model, even under uniform conditions of pressure and temperature. Therefore, reference images are used to compensate for the nonuniformity of the luminescence lifetime, which significantly diminishes the advantages of the lifetime imaging method. In particular, fast-responding PSPs show considerable variation in luminescence lifetime compared to conventional polymer-based PSPs. Therefore, this study investigated and discussed the factors causing the nonuniformity of the luminescence lifetime, such as the luminophore solvent, luminophore concentrations, binder thickness, and spraying conditions. The results obtained suggest that the nonuniformity of the luminophore distribution in the binder caused by the various factors mentioned above during the coating process is closely related to the nonuniformity of the luminescence lifetime. For example, when the thickness of the binder became thinner than 8 μm, the fast-responding PSPs showed a tendency to vary significantly in the luminescence lifetime. In addition, it was found that the luminescence lifetime of fast-responding PSP could be changed in the depth direction of the binder depending on the coating conditions. Therefore, it is important to distribute the luminophore uniformly in the binder layer to create PSPs with a more uniform luminescence lifetime distribution.