Development of squamous cell carcinoma in hepatitis C virus-associated lichen planus

Porter, Stephen; Lodi, Giovanni; Chandler, Kathryn; Kumar, Navdeep

doi:10.1016/s0964-1955(96)00041-3

Cited by 36 publications

(23 citation statements)

References 16 publications

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“…Hence, the ability to generalize the results to other racial/ethnic groups is unclear given that the transmission route of viral hepatitis infection in Chinese might not be the same as that in other ethnic groups. Fifth, there is some plausibility for the association of lichen planus (one of the most frequently reported oral extrahepatic manifestations of HCV infection) and oral cavity cancer [29]. However, the incidence of lichen planus in our subjects was not indexed on the insurance records.…”

Section: Discussionmentioning

confidence: 94%

“…In a Brazilian cross-sectional study, there was a significant association between oral lichen planus and hepatitis C in their cohort of 215 patients with chronic HCV infection [21]. The progression of lichen planus into OSCC in patients with hepatitis C has been described in two case reports [29], [30]. Several studies have shown that the transformation rate of oral lichen planus to OSCC is approximately 0.04% to 1.74% [31], [32].…”

Section: Discussionmentioning

confidence: 98%

“…In addition, one of the most frequently reported oral extrahepatic manifestations of HCV infection is lichen planus [26], [27], [28]. This premalignant condition is associated with the development of OSCC [29]. In a Brazilian cross-sectional study, there was a significant association between oral lichen planus and hepatitis C in their cohort of 215 patients with chronic HCV infection [21].…”

Section: Discussionmentioning

confidence: 99%

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Positive Association Between Hepatitis C Infection and Oral Cavity Cancer: A Nationwide Population-Based Cohort Study in Taiwan

Chang

Chen

et al. 2012

PLoS ONE

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ObjectivesThe association between viral hepatitis (B and C) and oral cavity cancer has been widely debated. This nationwide, population-based cohort study assessed the subsequent risk of oral cavity cancer among patients with chronic viral hepatitis infection.Materials and MethodsData were retrieved from insurance claims data of 1,000,000 randomly sampled individuals covered under the Taiwan National Health Insurance system. We identified a total of 21,199 adults with chronic viral hepatitis infection (12,369 with HBV alone, 5,311 with HCV alone, and 3,519 with HBV/HCV dual infections) from 2000–2005. Comparison group comprised 84,796 sex- and age-matched subjects without viral hepatitis during the same study period. Incidence and risk of subsequent oral cavity cancer were measured until 2008.ResultsThe incidence of oral cavity cancers was 2.28-fold higher among patients with HCV alone than non-viral hepatitis group (6.15 versus 2.69 per 10,000 person-years). After adjusting for sociodemographic covariates, HCV alone was significantly associated with an increased risk for oral cavity cancer (hazard ratio (HR) = 1.90, 95% confidence interval (CI) = 1.20–3.02). This positive association was highest among individuals in the 40–49-year age group (HR = 2.57, 95% CI = 1.21–5.46). However, there were no significant associations between HBV alone or HBV/HCV dual infections and risk for oral cavity cancer.ConclusionOur data suggest that HCV but not HBV infection is a risk factor for oral cavity cancer. In addition, subjects with HCV infection tend to be at early onset risk for oral cavity cancer. This finding needs to be replicated in further studies.

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Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Positive Association Between Hepatitis C Infection and Oral Cavity Cancer: A Nationwide Population-Based Cohort Study in Taiwan

Chang

Chen

et al. 2012

PLoS ONE

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“…Oral verrucous and squamous cell carcinomas have been reported in HCV-infected patients with or without OLP [9, [103][104][105][106][107][108][109] , although the epidemiological relevance of this observation is unclear and HCV is a common cause of liver cirrhosis, which may itself represent an independent risk factor for the development of oral cancer [110] .…”

Section: Oral Squamous Cell Carcinomamentioning

confidence: 99%

Oral manifestations of hepatitis C virus infection

Carrozzo

Scally

2014

WJG

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Extrahepatic manifestations (EHMs) of hepatitis C virus (HCV) infection can affect a variety of organ systems with significant morbidity and mortality. Some of the most frequently reported EHM of HCV infection, involve the oral region predominantly or exclusively. Oral lichen planus (OLP) is a chronic inflammatory condition that is potentially malignant and represents cell-mediated reaction to a variety of extrinsic antigens, altered self-antigens, or super antigens. Robust epidemiological evidence support the link between OLP and HCV. As the virus may replicate in the oral mucosa and attract HCV-specific T lymphocytes, HCV may be implicated in OLP pathogenesis. Sjögren syndrome (SjS) is an autoimmune exocrinopathy, characterized by dryness of the mouth and eyes and a multitude of other systemic signs and symptoms. SjS patients have also an increased risk of non-Hodgkin lymphoma. Patients with chronic hepatitis C do frequently have histological signs of Sjögren-like sialadenitis with mild or even absent clinical symptoms. However, it is still unclear if HCV may cause a disease mimicking SjS or it is directly responsible for the development of SjS in a specific subset of patients. Oral squamous cell carcinoma is the most common oral malignant tumour and at least in some part of the world could be linked to HCV.

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“…The herpes viruses most often linked to oral cancer are the Epstein-Barr virus (EBV), human herpes virus- (HHV-) 8, and cytomegalovirus (CMV) [9]. …”

Section: Introductionmentioning

confidence: 99%

Evidences Suggesting Involvement of Viruses in Oral Squamous Cell Carcinoma

Gupta

Metgud

2013

Pathology Research International

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Oral cancer is one of the most common cancers and it constitutes a major health problem particularly in developing countries. Oral squamous cell carcinoma (OSCC) represents the most frequent of all oral neoplasms. Several risk factors have been well characterized to be associated with OSCC with substantial evidences. The etiology of OSCC is complex and involves many factors. The most clearly defined potential factors are smoking and alcohol, which substantially increase the risk of OSCC. However, despite this clear association, a substantial proportion of patients develop OSCC without exposure to them, emphasizing the role of other risk factors such as genetic susceptibility and oncogenic viruses. Some viruses are strongly associated with OSCC while the association of others is less frequent and may depend on cofactors for their carcinogenic effects. Therefore, the exact role of viruses must be evaluated with care in order to improve the diagnosis and treatment of OSCC. Although a viral association within a subset of OSCC has been shown, the molecular and histopathological characteristics of these tumors have yet to be clearly defined.

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Development of squamous cell carcinoma in hepatitis C virus-associated lichen planus

Cited by 36 publications

References 16 publications

Positive Association Between Hepatitis C Infection and Oral Cavity Cancer: A Nationwide Population-Based Cohort Study in Taiwan

Positive Association Between Hepatitis C Infection and Oral Cavity Cancer: A Nationwide Population-Based Cohort Study in Taiwan

Oral manifestations of hepatitis C virus infection

Evidences Suggesting Involvement of Viruses in Oral Squamous Cell Carcinoma

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