Development of squamous cell carcinoma by two high-risk human papillomaviruses (HPVs), a novel HPV-67 and HPV-31 from bowenoid papulosis

Yoneta, Akihiro; Yamashita, Toshiharu; Jin, Hongfang; Iwasawa, Akihiko; Kondo, Shohei; Jimbow, Kowichi

doi:10.1111/j.1365-2133.2000.03718.x

Cited by 43 publications

(16 citation statements)

References 29 publications

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“…However this does not exclude malignant changes at a later time point, since the development, maintenance and progression of precursor lesions evolve slowly into invasive cancer, typically over a period of more than 10 years [27]. Yoneta and co-workers reported that a patient with Bowenoid papulosis involving HPV31, 67 infection developed invasive squamous cell carcinoma (SCC) 8 years following the Bowenoid papulosis' diagnosis [28]. Therefore a longer follow up time may be valuable for those Condyloma acuminatum patients who experienced HPV16/18 and/or HPV31/33 infection.…”

Section: Discussionmentioning

confidence: 99%

Significance of SHP-1 and SHP-2 Expression in Human Papillomavirus Infected Condyloma acuminatum and Cervical Cancer

Tao¹,

Shen

Pan³

et al. 2008

Pathol. Oncol. Res.

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Human papillomaviruses (HPVs) are a group of DNA viruses that infect the skin and mucous membranes. Type HPV6/11 is closely related to Condyloma acuminatum, while HPV16/18 is the principal cause of cervical cancer. In this study, we examined the expression of protein tyrosine phosphatases SHP-1 and SHP-2 in Condyloma acuminatum, cervical cancer and the relationship between SHP-1/SHP2 expression and HPV infection. Forty Condyloma acuminatum cases, 20 cervical cancer cases and 20 normal human foreskins were examined for HPV infection by in situ hybridization and the expression of SHP-1 and SHP-2 were examined by immunohistochemistry. Results demonstrated that positive expression rates of HPV6/11, HPV16/18, and HPV31/33 were 98%, 10%, and 7.5% in Condyloma acuminatum, 10%, 85%, and 25% in cervical cancer. Only one normal foreskin demonstrated positive staining for HPV16/18. Positive expression rates of SHP-1 and SHP-2 were 80% and 85% in Condyloma acuminatum, 85% and 90% in cervical cancer. The SHP-1 and SHP-2 expressions were mainly distributed in the prickle layer of Condyloma acuminatum and were diffusely distributed in cervical cancer cells. Only 35% and 30% of foreskins demonstrated weak staining in the basal layer cells. There were statistically significant correlations among the infection of HPV and the expression of SHP-1 and SHP-2 in both Condyloma acuminatum and cervical cancer (P < 0.05). SHP-1 expression has a positive correlation with SHP-2 expression. Our results demonstrate putative roles of SHP-1 and SHP-2 in the progression of both Condyloma acuminatum and cervical cancer after HPV infection.

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Section: Discussionmentioning

confidence: 99%

Significance of SHP-1 and SHP-2 Expression in Human Papillomavirus Infected Condyloma acuminatum and Cervical Cancer

Tao¹,

Shen

Pan³

et al. 2008

Pathol. Oncol. Res.

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“…No malignant changes were found in 54 BP patients after 5 years of follow-up [3]. Recently, however, 10 cases of SCC developed from BP, including the present case, have been reported [5, 6, 7, 8, 9, 10, 11, 12]. Associations have been reported in 5 cases (thyroid and colon cancer [6], uterine cervical cancer [8], HIV infection [9], leukemia [10], pancytopenia in the present case).…”

Section: Discussionmentioning

confidence: 95%

“…The cervical cancer with HPV infection is categorized in a mucosal high-risk group. Five cases of BP including the present one showed the presence of HPV-31 DNA [12, 14, 15, 16]. Three cases showed depressed immunity.…”

Section: Discussionmentioning

confidence: 99%

Elevated Amount of Human Papillomavirus 31 DNA in a Squamous Cell Carcinoma Developed from Bowenoid Papulosis

Hama

Ohtsuka²,

Yamazaki³

2004

Dermatology

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A 50-year-old woman presented with asymptomatic, multiple black macules on the genitalia for 6 months. She presented multiple, round to irregularly shaped, black macules on her labia major and perineum. A keratotic reddish nodule was found on one of the macules. The results of laboratory investigations showed pancytopenia and a decreased CD4/CD8 ratio. A lymphocyte stimulation test showed a decreased response. The histological examination of a biopsy specimen led us to the diagnosis of bowenoid papulosis (BP) for the macules and squamous cell carcinoma (SCC) for the nodule. The macules and nodule were removed successfully. An elevated amount of HPV DNA was demonstrated in SCC compared with that of BP. The HPV DNA in SCC and BP was shown to be HPV-31. These observations indicated that the elevated amount of HPV-31 DNA could have led to the emergence of SCC from BP under the condition of decreased cellular immunity.

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“…Das Tumorwachstum beginnt in der Regel nicht de novo; es entsteht meist auf vorgeschädigter Haut, wie beispielsweise bei Kondylombefall [1,4,11,13,14,20], bei Lichen ruber planus [5], Acne inversa [7,12,15,19], Morbus Crohn [10,16] und Lichen sclerosus et atrophicans [3,17,18]. Eine Immunsuppression begünstigt die Tumorentstehung [6,9].…”

Section: äTiopathogeneseunclassified

Leitlinie: Analrandkarzinom (Entwicklungsstufe S1, IDA: -)

Wienert

2004

coloproctology

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Zur Erstellung nachfolgender Leitlinie wurde die derzeit vorliegende Literatur systematisch recherchiert. Sie wurde anhand des Erkenntnismaterials verfasst und anschließend in drei jeweils mehrtägigen Konsensuskonferenzen diskutiert und ver abschiedet. Definition ICD 10: C44.5Das Analrandkarzinom (Plattenepithelkarzinom, Spinaliom, Stachelzellkarzinom) ist ein lokal infiltrierender, destruierend wachsender maligner Hauttumor, der sich auf dem Boden einer Analen Intraepithelialen Neoplasie (AIN) entwickelt und eher selten manifestiert. EpidemiologieDas Plattenepithelkarzinom, zweithäufigster maligner Tumor der lichtexponierten Haut, kommt im Analbereich selten vor. Brown et al. sahen in einem Zeitraum von 25 Jahren insgesamt 42 perianale Tumoren bei 26 Frauen und 16 Männern mit einem Durchschnittsalter von 56 Jahren. ÄtiopathogeneseDas Tumorwachstum beginnt in der Regel nicht de novo; es entsteht meist auf vorgeschädigter Haut, wie beispielsweise bei Kondylombefall [1,4,11,13,14,20], bei Lichen ruber planus [5], Acne inversa [7, 12, 15, 19], Morbus Crohn [10, 16] und Lichen sclerosus et atrophicans [3, 17, 18]. Eine Immunsuppression begünstigt die Tumorentstehung [6, 9]. Klinischer Befund Die AIN stellt sich als uncharakteristische ekzemartige Hautveränderung dar. Das eigentliche Analrandkarzinom manifestiert sich als derber, manchmal glatter, meist jedoch verruköser haut farbener bis rötlicher Knoten. Es wächst im Laufe von Monaten und Jahren peripher und in die Tiefe und zerfällt dann geschwürig. Bei Exulzeration haben die Patienten zunehmend Beschwerden. Sie klagen über Jucken, Nässen, Blutung und Schmerzen. Ohne Therapie infiltriert der Tumor in tiefere Gewebsstrukturen und metastasiert schließlich in die regionären Lymphknoten. Fernmetastasen treten nur selten auf. Bezüg-lich der Letalität finden sich in der Literatur keine aussagekräftigen Angaben. Die Prognose hängt von den Faktoren Tumorgröße, Primär-oder Rezidivtumor, Ausbrei tungs stadium, histologische Differenzierung und Immunstatus ab. Diagnostik Mittels Inspektion und Palpation wird die Verdachtsdiagnose gestellt, die histologisch gesichert wird. Es sollte die Dicke des Tumors bestimmt werden (sog. Microstaging). Der histomorpho logische Differenzierungsgrad (Grading) wird nach Broders in gut, mä-coloproctology coloproctology

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Development of squamous cell carcinoma by two high-risk human papillomaviruses (HPVs), a novel HPV-67 and HPV-31 from bowenoid papulosis

Cited by 43 publications

References 29 publications

Significance of SHP-1 and SHP-2 Expression in Human Papillomavirus Infected Condyloma acuminatum and Cervical Cancer

Significance of SHP-1 and SHP-2 Expression in Human Papillomavirus Infected Condyloma acuminatum and Cervical Cancer

Elevated Amount of Human Papillomavirus 31 DNA in a Squamous Cell Carcinoma Developed from Bowenoid Papulosis

Leitlinie: Analrandkarzinom (Entwicklungsstufe S1, IDA: -)

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